Posted by admin on Apr 30, 2022 in |
The present study was undertaken to study the anti-inflammatory effects of aqueous extract of Impatiens balsamina leaves in suitable animal models. The leaves of Impatiens balsamina were extracted with distilled water using the Soxhlet apparatus. The extract thus obtained was screened for anti-inflammatory activity using Cotton pellet implantation method, Granuloma pouch method, and formaldehyde arthritis method in albino rats. The aqueous extract of the plant produced significant inhibition of granuloma formation, significant inhibition of exudate formation and significantly inhibited rat paw oedema induced by formaldehyde as compared to respective controls in albino rats (p<0.05-0.001). The aqueous extract of the plant produced significant inhibition of granuloma formation 18.79% (p<0.01%), 29.13% (p<0.001%) and 44.83% (p<0.001%) at concentrations of 500 mg/kg, 1000 mg/kg and 2000 mg/kg respectively. The aqueous extract produced 36.34%, (p<0.01), 50% (p<0.001%) and 68.3% (p<0.001%) inhibition of exudate formation at 500 mg/kg, 1000 mg/kg and 2000 mg/kg respectively. The aqueous extract also significantly inhibited rat paw oedema induced by formaldehyde (p<0.05 -0.001). However, the extract was found to be...
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Posted by admin on Apr 30, 2022 in |
Four plant species Senna italica, Prosopis juliflora, Cressa cretica and Schouwia purpurea were selected to estimate phytoconstituents and quantify total phenols, tannins, and flavonoids. The total content of phenols, tannins, and flavonoids with the gallic acid curve by the standard method was estimated. The leaf extract of Senna italica contained maximum, and Schouwia purpurea contained a minimum amount of phenol. The maximum amount of tannins was found in Schouwia purpurea, and the minimum amount of flavonoids was recorded in Senna italica. It is further suggested that there are a need for systematic phytochemical, pharmaceutical and pharmacological investigations of these plants since there are less reports available. Moreover, these plants are accessible in abundant in Ballari region and can prove to be the best source for bioprospection studies since they contain high contents of phenols, tannins, and...
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Posted by admin on Apr 30, 2022 in |
Seven pathogenic isolates with clinical history were procured from the Department of Microbiology, RMMCH, Annamalai University, Chidambaram, Tamil Nadu. Among them, five isolates (S1-S5) showed multi-drug resistance to the selected antibiotics. Maximum multi-drug resistance was exhibited by four Gram negative isolates (S1, S2, S4 and S5). Initial qualitative analysis of these four isolates for biofilm forming efficacy by the Congo-Red Agar method revealed that three of these isolates (S1, S2 and S4) were biofilm producers. Maximum biofilm formation was exhibited by S4. Further qualitative analysis of biofilm formation by S4 using the Tube Adherence method yielded a positive result. Biofilm forming efficacy of S4 was then quantitatively analyzed by a spectrophotometric assay. An optical density of 0.38 was recorded at a wavelength of 540 nm, which was significantly higher than the O.D. value of the control (0.05), confirming biofilm formation by the...
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Posted by admin on Apr 30, 2022 in |
In Benin, several studies still confirm the circulation of low-quality anti-malarial drugs, despite efforts to improve the supply chain. It is, therefore, necessary to carry out post-market quality surveillance of the same to ensure that only quality and efficacious medicines are sold to the general populace. The aim of this work was to evaluate the post-market quality of fixed-dose combinations of artemether-lumefantrine marketed in Benin. This descriptive and analytical study was executed in four stages over fourteen months, from December 2019 to January 2021. Thirty samples of artemether-lumefantrine (80/480 mg) fixed-dose combination tablets were collected from sixteen pharmacies in Cotonou and Porto Novo. The various quality control activities and tests conducted were: visual identification, pharmacopoeial tests (weight uniformity and disintegration tests), identification tests, in-vitro comparative dissolution tests and active ingredients content determination by HPLC-UV. The results of our analyses showed that none of the samples passed the visual identification test; all the samples passed the weight uniformity test in accordance with the specifications of the European pharmacopeia (Eur Ph)....
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Posted by admin on Apr 30, 2022 in |
Metformin, the first-line drug, can reduce hepatic gluconeogenesis and increase insulin sensitivity. At the molecular level, metformin inhibits the mitochondrial respiratory chain, which leads to an increase in adenosine monophosphate-activated protein kinase, which increases insulin sensitivity. Recent guidelines advocate metformin as the first-line agent that has a glucose-lowering effect concurrently with lifestyle modification. Metformin has long been shown to decrease vitamin B12 levels. Vitamin B12 is also an essential micronutrient required for optimal hemopoietic, neuro-cognitive, and cardiovascular function. Vitamin B12 deficiency has been highly prevalent among patients with type 2 diabetes mellitus. In this study, we want to figure out the association between metformin administration and VitB12 absorption defects in a diabetic patient pool on metformin alone and metformin with other combination drugs. Findings from this study indicate the role of metformin in vitB12 deficiency, uncontrolled glucose levels, and levels of serum Minerals in T2DM patients, gradually leading to microvascular and macrovascular complications even with one year of usage of...
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