Posted by admin on Mar 31, 2022 in |
The Aim and objective of this work were to build up a gastro retentive drug delivery system. Cimetidine is used as a model drug for making mucoadhesive dosage forms. The formulation can be achieved by using the ionic gelation method. The model drug used in this work plan is categorized in antiulcer treatment. The extended-release mucoadhesive microspheres of the drug provide constant plasma concentration with a less frequent administration and also reduce the side effects to some extent. They provide good administration and enhance patient compliance. The present study aims to develop mucoadhesive microspheres of the model drug by using polymers like Sodium alginate and Carbopol 934 as an excellent mucoadhesive agent that can adhere to the gastrointestinal membrane for sustained drug delivery in the stomach. Calcium chloride was also used for making a solvent system. The preformulation study shows no interaction between drugs and excipients. The prepared microspheres of cimetidine particle size between 167.14-218.23μm. The entrapment efficiency of formulations was found to be 70.06-87.67%. In-vitro drug release after...
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Posted by admin on Mar 31, 2022 in |
Pain is the most common symptom of disease, which accompanies us from an early age. It is a safeguarding mechanism of the body from harmful stimuli. The definition of pain states that it is a subjective sensory and emotional experience. This study compared generic and brand drugs’ analgesics and anti-inflammatory activity using eddy’s hot plate method and plethysmometer models. Two studies were conducted by using oral and intraperitoneal routes of administration. In this study, generic drugs such as Ranbaxy, intagesic, and Diclovin. Branded drugs are such as Voveran, Dynapar, and Cipla are used. The analgesics activity and anti-inflammatory activity of generic and branded drugs are the same. So, it has been concluded that generic drugs also show same effect as branded...
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Posted by admin on Mar 31, 2022 in |
Coconut oil is an edible vegetable oil used in the food, pharmaceuticals, and cosmetics industries. Fatty acids are the major constituents of Coconut oil. Various methods were reported for the extraction of oil from coconut seed kernels. Extraction of coconut oil from its seed kernel using the probe sonication method is not reported in the literature. Hence, in the present study, oil was extracted using hexane and ethyl acetate. The physicochemical parameters like acid value, saponification value, refractive index, specific gravity, unsaponifiable matter, moisture content and iodine value were determined for the extracted oil. Oil samples after base-catalyzed derivatization were analyzed for the quantification of fatty acids by the GC-FID method. The percentage of oil extracted from coconut seed kernel was 31.84% and 36.32% for n-hexane and ethyl acetate extractions, respectively. Physico-Chemical parameters of the oils tested were within limits. Coconut oil obtained from n-hexane extraction contained the highest fraction of lauric acid. Oil extraction with probe sonication technique was found to be efficient as the percentage recovery of...
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Posted by admin on Feb 28, 2022 in |
Objective: Our work was to develop an ordispersible tablet of Dextromethorphan HBr with acceptable palatability to help patients of all age groups. Methods: The bitter taste of the drug was masked by entrapping the drug into Eudragit RL 100. The microspheres were prepared from solvent evaporation method. The effect of particle size, drug entrapment efficiency, % yield and % drug release of the microspheres was studied. Drug loading increased significantly with increasing the drug polymer ratio. Dextromethorphan was than further transformed into orodispersible tablet by using Hibuscus and Fenugreek as a superdisintegrants by using direct compression method. Physiochemical parameters and animal toxicity study of dried mucilage obtained from Hibiscus and Fenugreek were performed. In-vitro disintegration and in-vitro dissolution was carried out to observe the disintegration time and sustain release of drug. Results: In-vivo taste masked study was performed on albino rats. SEM, DSC and FTIR were done for identification, compatibility study and surface morphology. The or dispersible tablet made from sustained release microspheres showed release up to 10 h....
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Posted by admin on Feb 28, 2022 in |
The objective of current research is to assess the type of Adverse Drug Reactions (ADR) and associated risk factors, assess the prevalence, estimate the incidence of serious and fatal ADR and the severity of ADRs based on data collected from patients with ADRs caused by drug initially prescribed. Data of patients with acute diseases were collected and analyzed using SAS version 9.1. About 252 ADRs were identified among 183 patients. The majority of patients (70.49%) experienced one ADR reaction per patient. A higher risk of ADR was observed in the age group of 41-50 yrs (33.33%). The prevalence of ADR is predominant in adults (82.51%). ADR incidents were higher in gastrointestinal reactions (26.19%), with most of them identified by doctors or prescribers (44.41%). Suspected drug was withdrawn in 57.92% cases, specific and symptomatic treatment given to 45.23% followed by only symptiotic treatment for 30.95%. Definite improvement was predominant in challenged patients, whereas recurrence of symptoms was significantly observed among rechallenged patients with the respective suspected drug. According to the...
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