Posted by admin on Nov 30, 2021 in |
In an attempt of synthesizing some novel and potent antioxidant activity having compounds, here some novel quinoline derivatives are reported. Initially using Vilsemeir-Hack reagent method 7-methyl or 8-methyl substituted 2-cholro-3-formylquinolines (Ia, b) were prepared. Further 7-methyl or 8-methyl substituted 2-hydroxy quinoline-3-carbaldehyde (IIa, b) were synthesized by the reaction of compound (I) on microwave irradiation with 4M HCl, which on further treatment with different substituted hydrazides yielded the novel Schiff bases of quinoline III (a-f). Purity of the synthesized compounds was determined by TLC and melting point. The structure of all newly synthesized compounds was confirmed by spectral studies such as IR, 1H NMR, 13C NMR, and mass spectroscopy. All the synthesized compounds were screened for in-vitro antioxidant activity by free radical scavenging activity by DPPH assays method and ferric ion reduction method using ascorbic acid as the standard drug. Screening results showed that all compounds are exhibiting moderate to good activity. Especially compounds III b, III d, and III f showed significant antioxidant...
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Posted by admin on Nov 30, 2021 in |
The Screening of medicinal plants for the new bioactive compounds leads to the development of new anti-microbial drugs that possess lesser cost and greater safety and efficacy. The increasing bacterial resistance exhibited by microorganisms causing skin infections has led to the research on medicinal plants. Argemone Mexicana Linn is a weed that shows multiple health benefits. All the parts of the plant are traditionally well known for the treatment of skin diseases. The aim of present study is to investigate and compare the anti-microbial activity of aqueous and ethanol extract of leaves of Argemone mexicana Linn against skin infection-causing bacteria. Also, Functional groups associated with phytochemical compounds of these plant extracts are well understood from FTIR Spectroscopy. The Argemone mexicana Linn leaves extract shows significant anti-microbial activity against all the selected microorganisms for study. The results for anti-microbial activity were recorded in zones of inhibitions. The highest zone of inhibition had shown by the ethanol extract at higher concentration, i.e., 300 mg/ml against all pathogens. The MIC values of...
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Posted by admin on Nov 30, 2021 in |
Three analytical methods were developed for the determination of selected fluoroquinolones in chicken meat by high performance liquid chromatographic technique. In each method, we took two fluoroquinolones (Danofloxacin and difloxacin; Ciprofloxacin and enrofloxacin; Ofloxacin and pefloxacin) research study. Rapid, simple and sensitive sample treatment procedures were developed and used to extract the fluoroquinolones from the chicken tissues with good recoveries. Extraction recovery from chicken tissues was in the range of 86.96 to 97.49 %, depending upon the analytes. The shape of the curves for all drugs was linear in the investigation concentration range 10-1000 ng/ml, and the correlation coefficient of the linearity curves for all drugs was in the range of 0.9707- 0.9991. The detection limits for fluoroquinolones in chicken tissues were well below the Maximum Residual Limits (MRLs) for antibiotics. The limit of detection (LOD) was in the range of 9-12 µg/kg, and the limit of quantification (LOQ) was in the range of 30-40 µg/kg for all analytes in chicken tissues. The separation results and parameters of the...
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Posted by admin on Nov 30, 2021 in |
This study aimed to determine for taste masking & design of Oro dispersible tablet of an anticholinesterase agent (Donepezil HCl) to achieve the patient compliance. Oral dispersible tablet prepared by compression method. The Anticholinergic activity assure by evaluation, drug dissolution, stability testing and standardize the oral dispersible tablet. On the basis of the preformulating and formulation study, the batch 10-F009 formulation would maintain stability and potency throughout the study period. Complete drug release was observed at gastric pH. Taste masking and rapid disintegration of tablets formulated in this investigation may possibly help in the administration of Donepezil HCL in a more palatable form without water. Finally, this formulation with once-daily dose is convenient for patients with the Alzheimer’s disease and related dementia with good therapeutic activity and...
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Posted by admin on Nov 30, 2021 in |
Rabies is a fatal viral disease which is caused by negative sense, single-stranded RNA virus belonging to Rhabdoviridae family of genus Lyssavirus, Rabies Virus (RABV). It is transmitted by the bite of a rabid animal and directly affects the CNS of the host (neurotropic). Sources of human rabies deaths are dogs (99%), cats, bats, etc. Rabies holds the seventh position in the world for causing the most severe infections that result in the death of an organism. India lies on the top in the number of affected individuals with rabies. Our aim in this study is to analyze the interactions between the RABV and its human host and to develop novel therapeutic strategies to combat this deadly disease. Further analysis of the predicted protein-protein interactions can help us design strategies against clinical manifestations of the disease in humans. An in-silico approach has been adopted because computational approaches play a vital role in providing an important tool in further investigation of host-pathogen...
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