Posted by admin on Sep 30, 2025 in |
The active compounds present in plants gained attention for their biological activity and this makes them important for the pharmaceutical industries. Butea monosperma has significant role in traditional medicines. Its leaves, bark, and flower have an important role against diabetes, filariasis, ulcers, inflammations, etc. However, till date no detailed phytochemicals profiling in flowers of B. monosperma along with their antioxidant and antidiabetic potential has reported. This study aims to measure antioxidant activity, total phenols, flavonoid contents in methanol and ethanol extract of the flower, and to identify their compounds through Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Biological activity was determined by available literature present on NCBI, PubChem. However, Antioxidant actions were measured by DPPH and FRAP assays. Further antidiabetic potential of compound extract was analyzed using in-silico approach. It was found that methanolic extract showed better antioxidant potential than ethanolic extract. Total Phenol and flavonoid content were investigated but no significant difference was observed between the extracts. 42 major compounds were identified in methanolic extract using GC-MS, among which, 30...
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Posted by admin on Sep 30, 2025 in |
Necrotizing Enterocolitis (NEC) is a severe gastro-intestinal disease primarily affecting premature infants, especially those born at or before 32 weeks of gestation, and is associated with high morbidity and mortality rates, characterized by intestinal inflammation and necrosis. The purpose of this study was to investigate the role of genetic factors in the development of necrotizing enterocolitis, mortality cases, and potential links between these two conditions. A total of 44 infants were included in this study. Based on survival during the neonatal period, NEC were divided into two subgroups: those who survived (35 infants) and those who died 9 infants). SIGIRR gene methylations were identified through DNA isolation and standard PCR reactions. It was found that changes in the %C33, %C35, %C51 and %C102 gene loci are potential predictive markers for distinguishing infants who died from NEC from those without this pathology Genetic screening could help identify infants at a higher risk of developing NEC, allowing for timely, targeted intervention and personalized care...
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Posted by admin on Sep 30, 2025 in |
Current study aims to evaluate stability of Rebaudioside M, a sweet component of Stevia rebaudiana, using a typical pH (2.8, 3.2, 3.8 and 4.2) and temperature (5 °C, 20 °C, 30°C, 40 °C) for 26 weeks, range that simulated both relevant and extreme beverage storage conditions. Photostability of mock beverages at pH 3.8 was determined at 25 °C /60% relative humidity (RH) with fluorescent light exposure. Rebaudioside M (Reb M) was evaluated in mock beverage solutions by simulating formulations used in commercial soft drinks and were subjected to various temperature conditions (5 °C, 20 °C, 30 °C, 40 °C) for 26-weeks at each pH. Samples were analyzed at scheduled intervals throughout the 26 weeks for Reb M, known impurities, known degradation products, and unidentified compounds greater than or equal to 0.100% of the starting concentration of Reb M. There was minimal degradation of the Reb M when exposed to fluorescent light, and appearance did not change throughout the study. Thus, Reb M in mock beverages under relevant conditions of...
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Posted by admin on Sep 30, 2025 in |
Vertical transmission remains a major contributor to paediatric HIV infections despite significant advancements in antenatal care and the use of antiretroviral therapy (ART) and post-exposure prophylaxis (PEP). These measures have successfully reduced mother-to-child transmission rates, yet non-compliance with prescribed regimens continues to pose significant challenges. This retrospective study evaluates the effectiveness and safety of PEP in infants born to HIV-positive mothers at Goa Medical College from 2015 to 2022.A total of 97 infants born to HIV-positive mothers were included in the analysis. The study revealed a vertical transmission rate of 2.1%, with two infants testing positive for HIV. Both positive cases were associated with maternal non-compliance, either due to delayed initiation of ART or incomplete administration of PEP to the infant. No significant adverse effects of PEP were observed, indicating its safety and tolerability. The findings underscore the critical role of maternal adherence to ART and strict implementation of PEP protocols in preventing HIV transmission. Comprehensive counselling and robust support systems are essential to address compliance issues and optimize...
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Posted by admin on Sep 30, 2025 in |
Background: Self-medication is a common practice among medical students due to their exposure to pharmacological knowledge and easy access to drugs. This reflects a gap between knowledge and behavior driven by perceived convenience and confidence in their medical knowledge. Objectives: To assess the knowledge, attitude, and practice (KAP) of self-medication among undergraduate medical students using a structured questionnaire. Methods: A cross-sectional study was conducted using a pre-validated questionnaire on 150 medical students. The data collected were analyzed using descriptive statistics and Chi-square tests to identify trends and associations between demographic variables and self-medication practices. Results: 78% of the students reported practicing self-medication. Most had adequate knowledge but showed casual attitudes. Common drugs used included antipyretics, analgesics, antacids, and antibiotics. 46% were unaware of the potential dangers of self-medication, such as adverse drug reactions and antibiotic resistance. Conclusion: Educational strategies must be implemented to promote rational and responsible drug use among medical...
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