Posted by admin on Jul 31, 2021 in |
Introduction: Global pneumonia mortality (50%) caused by pneumococcus is responsible for invasive pneumococcal disease. Pneumococcal Conjugate Vaccine (PCV) has been introduced by the Government of India in a phased manner in selected states, but Haryana was not included. Objective: To draw key lessons learned from the process of newer vaccine introduction (PCV) in Haryana from the state’s resources to inform future introductions of PCV and any other new vaccine in other states of India and internationally. Methods The process of PCV introduction in Haryana was introduced with the launch of “Atal Jeevan Rakshak Teekakaran Yojna,” in 22 districts of the Haryana. The highest political and administrative leadership with a strong commitment to reducing the IMR and U5MR, approved the proposal and budget (~12 million USD). It was planned use of the of PCV13, and follow the National Immunization schedule i.e. 2 primary and 1 booster dose at 6, 14 weeks, and 9 months. The State-level launch ceremony of PCV introduction was organized in November 2018. Findings: Haryana became the...
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Posted by admin on Jul 31, 2021 in |
Colon carcinogenesis is a multistep process that arises by the accretion of genetic alterations. The genetic and epigenetic changes which transform normal colonic epithelium into aberrant crypt foci which is responsible for penetration. The GC-MS analysis of ethanolic extract of Epiphyllum oxypetalum (DC.) have shown the presence of phenolic compound (4-hydroxy-2-methylacetophenone), Diterpene, steroids which were reported for antioxidant and anticancer activity. In the present study Brine shrimp lethality, Trypan blue assay, and MTT assay in-vitro models are performed. In an in-vivo study, animals were divided into 5 groups as Normal, Control (NMU + distilled water 10ml/kg.), Standard (5-Flurouracil with the dose of 10mg/kg via intraperitoneal route given once in a 3 days of interval for 15 days to complete 5 cycles.), Test I (100mg/kg absolute ethanol extract of leaves of plant Epiphyllum oxypetalum (DC.)) and Test II (200mg/kg absolute ethanol extract of leaves of plant Epiphyllum oxypetalum (DC.)) groups each group comprised 6 animals. Cancer were induced in rats by using N-Methylnitrosourea by intra-rectal instillation method in a dose of 0.4% solution...
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Posted by admin on Jul 31, 2021 in |
Background: This was a conventional comparative treatment-controlled study designed to analyze the effect of dopamine infusion in the treatment of prerenal azotemia (PRA). Material and Methods: thirty randomized consecutive adult patients (group A= 15, B=15) aged 18 and 58 years with PRA were recruited. Group a received conventional treatment only (fluid replacement and frusemide), while group B received conventional treatment and dopamine. 24 hours urine volume, hemodynamic changes (pulse and blood pressure), serum electrolyte, urea, and creatinine were measured for the first 5 days of hospitalization. Duration of oliguria and hospitalization, mortality, number of patients who developed acute tubular necrosis (ATN), and or required dialysis was computed. Results: Duration of oliguria and hospitalization were shorter in group B than in group A patients (P = 0.025). The daily and hourly urine output was more in group B than in group A patients (P = 0.025). However, from the second day, patients in group B excreted more sodium than patients in group A (P = 0.001). 5 patients in group...
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Posted by admin on Jul 31, 2021 in |
Traditionally Persea schiedeana is used for headache relief, as anti-hypertensive, nervous relaxant, dermal diseases, among others. In this study, this plant from Salvadorian flora acute toxicity was evaluated in-vivo at 500 mg/kg, and the analgesic activity was tested by acetic acid, formalin, and tail flick tests in NIH Swiss mice at doses of 100, 250, and 500 mg/kg body weight, using as a positive control Indomethacin 10 mg/kg and distilled water as a control. Secondary metabolite profile was performed by Thin Layer Chromato-graphy (TLC) and ultra-efficient liquid chromatography-mass spectrometry (UPLC-MS). It was determined by TLC, the presence of terpenoids, flavonoids, tannins, lactonic groups, and coumarins, while UPLC-MS confirmed the presence of scopoletin. The biological assays demonstrated that P. schiedeana was deprived from toxic effect at the doses tested and the analgesic activity was confirmed in aqueous, ethanol, and dichloromethane extracts of Persea schiedeana leaves. Additionally, it was detected the presence of terpenoids, flavonoids, condensed tannins, lactones, and coumarins, and by UPLC-MS, the identity of coumarin as scopoletin was confirmed....
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Posted by admin on Jul 31, 2021 in |
In Ayurveda, ghrita (ghee) and taila (oil) are commonly used for treatment either internally or externally. It is commonly believed that by consumption of oil or ghee will lead to hyperlipidemia. Hyperlipidemia is an ailment of lipid metabolism produced by an increase of plasma concentration of the various lipid and lipoprotein, which cause cardiac disease, premature coronary artery disease, stroke, atherosclerosis and pancreatitis. Before the preparation of anyoushadhi siddha (medicated) taila (oil), and ghrita (ghee), murchana (processing of ghee) is a kind of samskara (procedure) mentioned in bhaishajya ratnavali. On administration of panchatikta ghrita prepared by a murchita and murchita ghrita (processed ghee) in albino rats, the results shown murchana samskara (processing of ghee) helps to reduce total cholesterol, LDL, triglycerides and increase in HDL. Guna (properties) and karma (action) of the drugs used in the panchatikta ghrita and murchana samskara (processing of ghee) might have contributed. Recent studies also show that triphala, musta (Cyperus rotandus), haridra (Curcuma longa), and matulunga (Citrus medica) are used for murchana samskara (processing...
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