Posted by admin on Oct 31, 2021 in |
Diabetes is a group of metabolic diseases and emerged as a major healthcare problem. According to the International Diabetes Federation (IDF), India has a large number of people suffering from diabetes, which will increase to almost 101 million by the year 2030. The pharmacotherapies of diabetes mellitus are diversified in their mechanism of action, safety profiles and tolerability. Drug utilization studies are important for the optimization of drug therapy. The present study aimed to evaluate the drug utilization pattern of anti-diabetic drugs in a tertiary care teaching hospital. It was a cross-sectional study, enrolled 255 patient’s prescriptions. Information was noted from prescriptions prescribed to the patients by a Doctor in prepared pro forma. It was found that combination therapy is predominant over monotherapy. The study has indicated metformin as the predominantly recommended oral anti-diabetic drug both as monotherapy and combination therapy. Metformin + glimepiride was the most commonly prescribed in combination therapy. The highest adverse drug reactions reported in our study are metformin + glimepiride which is different from...
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Posted by admin on Oct 31, 2021 in |
Drugs play a vital role in maintaining and promoting health. The safety, efficacy, and quality of the drugs must be assessed to protect the health of the user. Diclofenac is a cyclooxygenase inhibitor and one of the most useful, effective commercially available NSAIDs used in the management of pain. Many different brands and dosage forms (tablets, oral powder, and suppositories) of diclofenac are available on the market. This study sought to determine the quality as well as the physicochemical equivalence of 10 diclofenac suppositories brands. The sampled suppository brands had their registration status verified from the FDA. They were subjected to in-vitro tests associated with the quality of suppository dosage form, and the tests were conducted according to the United States Pharmacopeia and British Pharmacopeia standards. Two of the brands had an expired registration, whiles two (2) also had not been registered. All except two of the brands complied with the USP for uniformity of weight; they all passed the disintegration test. The FTIR identification test proved the presence...
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Posted by admin on Oct 31, 2021 in |
The current research involves the study of a Nimodipine self-nanoemulsifying drug delivery system (SNEDDS) with improved bioavailability and solubility. Fifteen formulations of Nimodipine SNEDDS were prepared prior to evaluation of particle size, emulsification time, percentage drug release, percentage transmittance, thermodynamic stability and in-vitro drug release. The formulation F13 was chosen as an optimized formulation with the composition of Peceol, Transcutol P, and PEG 400. The optimized Nimodipine SNEDDS formulation (F13) subjected to drug-excipient compatibility studies by FTIR. The particle size of the optimized Nimodipine SNEDDS formulation was 25.9 nm, PDI is 0.382, and zeta potential -12.7 mV that are optimal for the stability of the emulsion. SEM studies of Nimodipine SNEDDS indicated spherical shape and uniform particle distribution. Furthermore, Pharmacokinetic studies were conducted in rats, and plasma drug concentration-time curves revealed that significant increase in optimized SNEDDS concentration compares to that of a drug. Hence a potential SNEDDS formulation of Nimodipine developed with increased dissolution rate and solubility and...
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Posted by admin on Oct 31, 2021 in |
Mercury toxicity is the most hazardous problem emerging in the world as its accumulation is escalating persistently through the increased utility of mercury in medicinal, industrial, and domiciliary usage. Subjection to mercury illustrates a consequential provocation to humans and other living biomes. The intention of the present research was to investigate the shielding potential of betulinic acid and rotundic acid against mercury chloride (HgCl2) (1.29 mg/kg b. w.) induced renal toxicity in adult males rats. The examination was implemented in male albino wistar rats (n = 36). Which was partition into six gatherings as follows: Control, HgCl2, HgCl2 + betulinic acid, HgCl2 + rotundic acid, betulinic acid alone, and rotundic acid alone. The results revealed that intense HgCl2 regulation modified different biochemical specifications incorporated with the elevated volume of lipid peroxidation (LPO) portion and a significantly depleted level of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) pursuits in the kidney tissue. Betulinic acid and rotundic acid is a natural antioxidant assist to safeguard oxidative...
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Posted by admin on Oct 31, 2021 in |
The research aim is to develop and evaluate Centella asiatica Chloroform extract and silver-coated suture against the most common organisms that cause surgical site infections (SSI) by in-vitro methods. This prospective study is to coat the Centella asiatica (CA) extract to the suture along with the silver nitrate solution. In this study, a suture filament was formulated with Poly Lactic Glycolic Acid (PLGA) (50:50 ratio). A formulated filament was coated with Centella asiatica extract, and its property was compared with the marketed future. After minor modifications, the marketed suture was coated with Centella asiatica extract. Antibacterial efficacy of Centella asiatica extract coated suture filaments with and without silver nitrate solution were evaluated against gram-positive and gram-negative bacteria. Chloroform extract of Centella asiatica powder was effective against gram positive and negative bacteria compared to crude powder. Particle size and Zeta potential of the CA powder extract with and without silver nitrate at the end of 3 h was found to be 676.9 and 140.1nm and 0.295 1.45mv of Zeta potential,...
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