Posted by admin on May 31, 2021 in |
This study aims to identify the suitable method for extraction of polyphenols from Acacia leucophloea bark using enzymes and to optimize the processing condition for extraction using Response Surface Methodology. A microwave-assisted enzymatic extraction (MAEE) method was developed and optimized to augment the polyphenol yield. The optimal extraction conditions were as follows: the amount of cellulase 1%, agitation speed 108 rpm, incubation time 1.5 h, and irradiation time 6 min. Under these conditions, polyphenol yield could reach 6.31%, which was higher than other extraction methods studied. The antioxidant activity of the crude extract and the encapsulated extract was evaluated by DPPH radical and reducing power assay. The antibacterial activities of crude extract and the encapsulated extract were studied using the disc diffusion technique. Among the tested bacteria, Klebsiella pneumoniae was most susceptible to polyphenol extract with the highest inhibition zone of 18.6 ± 0.5 mm at the concentration of 8 mg/mL. The outcome of the study indicates that the MAEE method was efficient and eco-friendly, and the polyphenols have...
Read More
Posted by admin on May 31, 2021 in |
The main objective of the present research work was to formulate and characterize the linagliptin-loaded solid lipid nanoparticles (SLNs). SLNs possess distinctive characteristics like small and spherical shapes with an average diameter between 1to 100 nm. Linagliptin is used for the treatment of type II diabetes and it is a dipeptidyl peptidase 4-inhibitor and its oral bioavailability is 30%. The application of biopharmaceutical principles to the physicochemical properties of drug substance are characterized with the goal of designing best drug delivery system. The current research work was to enhance the oral bioavailability of linagliptin using the different phospholipids like stearic acid, glyceryl monostearate, cholesterol along with the surfactants like tween 80, span 80, poloxamer1 88, and span 20 by solvent emulsification/solvent evaporation method and solvent emulsification method in order to obtain the best novelty formulation. The prepared formulations have been evaluated for particle size analysis, zeta potential, percentage drug entrapment efficiency, scanning electron microscopy studies, in-vitro drug release kinetics, and stability studies. FT-IR spectra showed the there was no...
Read More
Posted by admin on Apr 30, 2021 in |
Background: Management of hypertension in hemodialysis patients was never the same in all and tends to involve a various classes of drugs with respect to their disease conditions, response to drug therapy, medication adherence, and many more. Atenolol and Olmesartan can be used as add-on therapy in managing hypertension with calcium channel blockers. Methodology: Blood pressure was monitored using Continous Ambulatory Blood pressure monitoring for 24 h and patients with blood pressure above 160 mm Hg and who are free from Atenolol or Olmesartan were included in the study. They were given with Atenolol or Olmesartan as an add-on drug to the existing other class of antihypertensive drugs. After a period of 2 weeks, their 24 h ambulatory blood pressure was measured again. A comparative data of both the blood pressure data was established. Results: The overall 24 hours ambulatory systolic blood pressure dropped from 179.32 ± 10.823 to 168.36 ± 13.991, and overall diastolic pressure dropped from 90.72 ± 13.743 to 81.32 ± 12.750. Similarly, the mean heart...
Read More
Posted by admin on Apr 30, 2021 in |
Room temperature ionic liquids (RTILs), a class of green and neoteric solvents, have attracted increasing interest over recent years as environmentally benign excellent alternatives to organic solvents in homogeneous and biphasic processes synthesis of several nanoparticles. A novel magnetically recoverable ionic liquid (1,1–Bis(3-Methylimidazolium-1-yl)methanechloride)-stabilized ferrous sulfide (FeS NPs) was fabricated by almost all the known a simple reduction method. Firm ferrous sulfide nanoparticles were prepared in good capitulate by reduction of ferric chloride using sodium borohydride by different reagents like thioacetamide (TAA) and sodium thiosulfate in the presence of ionic liquid such as 1,1-Bis(3-Methylimidazolium-1-yl) methane chloride. In the present investigation, FeS nanoparticles through different starting materials were synthesized and its characteristics were compared with each other. Structures were confirmed by elemental and spectral studies such as FT-IR spectroscopy, X-Ray Diffraction (XRD) analysis, Scanning Electron Microscope (SEM) analysis, Energy Dispersive X-ray spectroscopy (EDX), and Transmission Electron Microscopy (TEM)...
Read More
Posted by admin on Apr 30, 2021 in |
In the present study, Justicia adhatoda was used for synthesizing AgNPs and characterized using UV-visible, FTIR, XRD, and SEM analysis and checked for its teratogenic effect and bactericidal activity. UV–Vis spectra analysis revealed that the synthesized AgNPs had a peak around 434 nm, while XRD and SEM analysis showed that AgNPs have spherical shapes with sizes ranging from 22 to 29 nm. Fourier transmission infrared (FTIR) analysis authorized the presence of bio interactive hydroxyl, amide, and carbonyl groups playing an important reduction role in the process of nano-synthesis. The acute developmental toxicity of Justicia adhatoda leaf extracts with nanosynthesised AgNPs on the embryos of the zebrafish, Danio rerio, revealed that the mortality, hatchability, heartbeat rate, teratogenicity, and embryogenicity were all concentration-dependent. The lethal effects were prominent in biosynthesized AgNPs, whereas sub-lethal and teratogenic effects like lordosis, scoliosis, pericardial edema, yolk sac edema, head malformation, tail malformation, and growth retardation were expressed in 79% of the embryos. Pericardial edema and Tail malformation were the most prevalent in higher concentrations signifying...
Read More
