Posted by admin on Jul 31, 2021 in |
Integration of nano-science in medicine leads to the development of biomedical products that help society in a faster and safer manner. In the present studies, Zinc nanoparticles were synthesized by green synthesis route using aqueous extracts of Banium persicum, and characterization was done through UV, SEM, TEM, FT-IR, and XRD. The synthesized nanoparticle was spherical in shape with an average size of 20 nm. Various bioactive compounds present in aqueous extract of this plant were responsible for bioreduction of nanoparticles. Further, these nanoparticles were tested for various biological activities. In antimicrobial activity maximum, anti-bacterial activity was observed against S. aureus at 120 µg/ml (IZ-18 mm),while in the case of fungus, maximum potential was observed at against C. albigans at 120 µg/ml (IZ- 30 mm). Further nanoparticles were screened for their antioxidant activity by LPO, Peroxidase, and Catalase assay and found they possessed potent antioxidant activity. The platelet aggregation of nanoparticles was assayed by Prothrombin (PT) and Activated Partial Thromboplastin time (APTT). In PT assay, maximum activity was observed at...
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Posted by admin on Jul 31, 2021 in |
The plant Scoparia dulcis Linn. belongs to the family Scrophulariaceae, is a native of tropical America, commonly called a sweet broom. The traditional healers identified its uses as anti-diabetic, antipyretic, antihypertensive, diuretic, and they have developed many promising traditional medicines and formulations from this plant. The main objective of this present study reveals about the phytoconstituents present in the leaves extract by preliminary phytochemical study, isolation of active compounds by column chromatography, and characterize the isolated compound by spectral studies like UV, IR, NMR, and MASS spectra. The preliminary phytochemical study reveals that the plant possesses more phytochemicals such as carbohydrates, alkaloids, tannins, phenols, flavonoids, vitamin C, and amino acids. The quantitative estimation shows that it consist of a considerable quantity of flavonoids, Phenols, Vitamin C. The methanol extract was prepared and applied in column chromatography to isolate the phytoconstituents. A dull white crystalline compound was isolated in the fraction of Acetone: Ethanol (60:40), (40:60) ratio. This compound was subjected to spectral studies. The spectral studies indicate the presence...
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Posted by admin on Jul 31, 2021 in |
This paper presents the antimicrobial activity of instant coffee, a prevalent beverage utilized by millions of people worldwide every day. Several studies have shown that instant coffee contains many useful bioactive compounds, the most important: caffeine, trigonelline, chlorogenic acid, ferulic acid, caffeic acid, nicotinic acid, and phenolic compounds which are responsible for the antimicrobial activity. In this study, six strains of resistant bacteria were selected as follows (Methicillin-resistant Staphylococcus aureus MRSA, S. aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia, and Acinetobacter baumannii). The antibiotic sensitivity test revealed that the most tested bacterial strain was utterly resistant to the selected antibiotic discs. The antimicrobial activity of instant coffee was evaluated at different concentrations (20, 40, 60, and 80 mg/ml) against tested multi-drug resistant bacteria (MDR) and the fungi (A. niger and A. flavus). The results of antibacterial effect of instant coffee showed that the inhibition zone ranged between (7.6±0.5 and 19.6±0.5 mm). While the minimum inhibitory concentration (MIC) ranged between (62.5 and 32.25 mg/ml) against tested bacteria. Moreover, the instant...
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Posted by admin on Jul 31, 2021 in |
The present paper deals with the pharmacognostical and phytochemical investigation of Fumaria parviflora Lam. whole plant. The qualitative and quantitative phytochemical analysis was carried out for the important bioactive constituents present in Fumaria parviflora Lam. (whole plant) in its Hydroalcoholic extract. The preliminary phytochemical analysis showed the presence of alkaloids, phenols, flavonoids, carbohydrates, protein, steroids, and sulphate. The total phenolic content (TPC) and the total flavonoid content (TFC) were also determined from the extrapolation of calibration curves which were prepared by using Tannic acid and Quercetin respectively as standard solutions. The results indicated the presence of phenols and flavonoids in considerable amounts. Thus, the study revealed the presence of various bioactive constituents in F. parviflora which could be exploited for their potential applications for medicinal...
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Posted by admin on Jul 31, 2021 in |
Several studies undertaken in the recent past have demonstrated that endophytic fungi are capable of producing a number of important bioactive secondary metabolites, hitherto known only from plants, thereby raising the potential of using endophytes as alternative sources for these metabolites. Occasionally, the compounds produced by endophytic fungi are similar to those produced by the respective host plants. The plant chosen for the current study has significant medicinal and therapeutic value, and endophytic fungi were isolated from the leaves of this plant. The leaves have been specifically chosen for this study as there is significant evidence suggesting that the leaf extracts of these plants have higher medicinal value. The hypothesis of this current study is that endophytic fungi isolated from leaves of the medicinal plant and its extract would exhibit similar or greater medicinal properties as that of leaf extracts. This work intends to highlight the bioactive potential of endophytic fungus Curvularia lunata isolated from Ficus religiosa. Extracts obtained from the fungi understudy were tested in-vitro for their possible...
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