Posted by admin on Jun 30, 2021 in |
Atorvastatin calcium is a synthetic lipid-lowering agent used in hyperlipidemia. An oral dose of Atorvastatin calcium ranges from 10mg to 80mg per day. Atorvastatin calcium belongs to BC’s class II drug having low solubility and high permeability. The absolute bioavailability of Atorvastatin calcium is approximately 12%, and the systemic availability of HMG-CoA reductase inhibitory activity is approximately 30%. The low systemic availability attributed to presystemic clearance when given through oral route several approaches have been tried to improve the solubility of a drug by preparing oral formulation such as tablets, nanosuspension, nanoemulsions, and sustained release dosage forms, there was no article on nasal administration of Atorvastatin calcium. The objective of the present research study was to formulate and evaluate nasal solution containing Atorvastatin calcium 10 mg per 2 drops. As from saturation solubility studies of the drug in pure form, solid dispersions, and β-cyclodextrin inclusion complex of a drug, it was observed that the drug in a pure form showing greater solubility in propylene glycol. A nasal formulation containing...
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Posted by admin on Jun 30, 2021 in |
The objective was to study the antihypertensive effects of the aqueous decoctycrude of Lippia multiflora from the region of Djidja at a dose of the plant as well as the effects of this extract on some biochemical parameters in the rat were made hypertensive by 500 mg/kg of body weight during the 14 days and were treated with losartan potassium at a dose of 100 mg/kg of body weight, of L-NAME at a dose of 40 mg/kg of body weight between 150 and 250g. Administration of L-NAME was caused a significant increase in PAS, PAD, and PAM in rats from 142.4±19.89 mmHg (J0) to 172.4±15.95 mmHg (J8) and 122.8±7.05 mmHg (J0) to 138.6±36.39 mmHg (J8), from 93.8±5.42 mmHg (J0) to 137.5±11.90 mmHg (J8) and from 92.5±4.55 mmHg (J0) to 136.75±7.68 mmHg (J8) and 109.25±15.52 mmHg (J0) to 159.75±27.80 mmHg (J8) and from 99.8±13.39 mmHg (J0) to 151.25±8.13 mmHg (J8) respectively for the positive control batch and the batch subsequently were treated with the raw extract). That of the crude...
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Posted by admin on Jun 30, 2021 in |
The demand for herbal medicines is growing at a drastic rate due to their improved pharmacological actions, minimal side effects, and cost-effectiveness. The ever-increasing cost of chemotherapy ruined the economic stability of many families. This led to the discovery of herbal medicines for cancer treatment. Tribes of Western Ghats have been using the roots of Apama siliquosa for cytotoxic activity. The methanolic and aqueous root extracts of Apama siliquosa Lamk were used to prepare different concentrations. These different dilutions of extract were used to carry out brine shrimp lethality assay & the LC50 value was determined. Cell line study by MTT assay using cancerous cell line (MCF7 cells-human breast adenocarcinoma cells) & LC50 value was determined. GCMS study on plant extract was carried out. The methanolic extract shows the presence of Caryophyllene oxide (m/z 220) methyl ester of Aristolochic acid I (m/z 355), Aristolactam I (m/z 295). Aristo lactam II (m/z 265), and Aristo lactam III (m/z 281). The aqueous extract shows the presence of Aristo lactam I (m/z...
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Posted by admin on May 31, 2021 in |
Biotransformation is a biological process in which the microbes are converting one form of compound to the another form. In the present research work, we studied about the conversion of Quercetinto kaempferol, which is having more therapeutic potential. Flavonoids are diverse group of secondary metabolites found especially in all plants. Flavonoids have Anti-carcinogenic, Anti-inflammatory, antioxidant, and Anti-allergic properties. Our study Quercetinis transforming into Kaempferol by Aspergillus niger (Allium cepa) through fermentation process at 37 ºC, PH 6 under aerobic conditions. The Transformed product (150 mg flavones / 200 ml medium) was extracted and analyzed by the spectral analysis (UV, IR, H-NMR, C-NMR) and mass spectrometry analysis process. The trans-formed product has more therapeutic potential in the treatment of wide range of cancer like breast, ovarian, gastric, pancreatic, lung...
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Posted by admin on May 31, 2021 in |
The main objective of this study was to Assessment of the acute toxicity of ethanolic extract of Polyherbal formulation in Swiss albino mice. In this study, the acute oral toxicity study of ethanolic extract of PHF1 was carried out according to Organization for Economic Co-operation and Development (OECD) guideline 423 and 407 on Swiss albino mice (20–30 g). In the study, the oral dose of 2000 mg/kg of PHF1 extract was administered in the treated group. General behavior, morbidity, and mortality were determined up to 72 h and compared to control group. Further animals were investigated for a period of 3days assess any other toxic effect. Behavioral changes and other parameters such as body weight, hematological parameters, and biochemical parameters were evaluated and compared to the normal group. The result of the study was mentioned that In acute toxicity study, treatment groups revealed neither morbidity nor mortality or any significant changes in behavior only drowsiness, sedation, and lethargy were observe in the group having 2000 mg/kg of Polyherbal formulations...
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