Posted by admin on Jun 30, 2021 in |
Postoperative atrial fibrillation (POAF) is a frequent rhythm disturbance after cardiac surgery and is associated with poor cardiovascular outcomes. Beta-blocker therapy is an effective strategy to prevent or decrease the high incidence of POAF and β1-adrenergic receptor (β1AR) polymorphisms that affect the cardiac response to β1AR antagonists. The study objective is to analyze the association between genetic variations in the β1AR gene and the risk of POAF and the prophylactic effect of beta-blockers. Totally, 198 patients undergoing first-time cardiac surgery were examined. The patients after operation were grouped as either with POAF or without POAF according to their continuously electrocardiogram monitoring within ICU and hospital admission period. Subsequently, genotype frequencies of the β1AR gene were determined by polymerase chain reaction-restriction fragment length polymorphism. The results showed that 63 patients (31.8%) of the total study population developed POAF. After the application of a multivariate logistic regression model, the incidence of POAF was associated with Arg389Gly genotype (OR=2.48; 95% CI, 1.06-5.76; p=0.036), Arg389Arg genotype (OR=3.38; 95% CI, 1.28-9.33; p=0.018) and Arg389Ser49...
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Posted by admin on Jun 30, 2021 in |
Fluvoxamine Maleate, an oral serotonin reuptake inhibitor, has been used widely for the treatment of anxiety. Sustained-release matrix-type drug delivery system has advantages over conventional modes of drug administration, enhancing drug bioavailability as it avoids the first-pass metabolism and improves patient compliance. Optimization of the formulation was performed by varying the concentration of natural polymer Moringa oleifera gum and HPMC K100, i.e., releases retarding polymers. Sustain release matrix tablets were formulated, and the drug release profiles of formulations F3 and F6 were found to be 93.8008% and 96.94108%,...
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Posted by admin on Jun 30, 2021 in |
The present study was proposed to develop a simple, rapid, and economical UHPLC method was described for the method development, validation and forced degradation for the simultaneous estimation of glycopyrrolate and formoterol fumarate in bulk drug. The chromatographic conditions were observed in the column using Zorbax RXC18 (150 × 4.6 mm) 5 µm using a mobile phase composition of Water: Acetonitrile: Methanol (20:30:50 v/v) and pH was adjusted to 3.0 with dilute orthophosphoric acid. The flow rate was 1.0 ml/min, and the analytes were recorded at 279 nm. The Retention time (RT) was observed in 1.208 for Glycopyrrolate and 5.897 for Formoterol fumarate. A calibration curve was linear with a coefficient correlation between 0.999 to 1.0 over a concentration range of 20-60µg/ml for glycopyrrolate and formoterol fumarate. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.003,0.011µg/ml for Glycopyrrolate and 0.108,0.32µg/ml for formoterol fumarate. All the validation parameters were within the acceptance range according to ICH norms. The validation and forced degradation study was...
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Posted by admin on Jun 30, 2021 in |
This article presents a logical technique to select the best method for the preparation of nanocrystals by implementing the analytic network process. One of the most significant decision-making tools to make excellent decisions is Analytic Network Process which includes Model construction, Paired assessments between each two clusters or node, Super matrix assessment based on outcomes from paired comparisons, and result investigation for the evaluation. So in order to avoid wrong conclusions, we use the Analytic Network Process tool because it is well organized and logical compared to other decision-making techniques. Based on the results of the overall priority analysis, the alternative M2 Sonoprecipitation method scores 0.088857, which is highest when compared to other alternatives. This study reveals that the Sonoprecipitation method is the most appropriate technique for the preparation of Nanocrystals. This paper concludes that ANP evolved by Saaty is a good decision-making device, done by using a software super decision which is very easy to make the right decision and conclusion. With the outcome of ANP method and...
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Posted by admin on Jun 30, 2021 in |
Aim of the study: To evaluate analgesic and anti-inflammatory activities of cetirizine and levocetirizine in different experimental models in rats. Materials and Methods: Analgesic activity of cetirizine and levocetirizine was assessed in tail flick model in rats (n = 6), where it was compared with aspirin and tramadol. Reaction time in seconds was used as the unit for measurement of pain and an increase in reaction time was indicative of analgesia. Anti-inflammatory activity of cetirizine and levocetirizine was evaluated using carrageenan-induced rat paw oedema model for acute inflammation (n=6). Percentage inhibition of oedema was compared in different groups. Formalin-induced arthritis model in rats (n=6) was used to evaluate activity in chronic inflammation, where it was compared with aspirin. Linear cross-section (LCS) immediately below the ankle joint of right hind paw was measured daily with Vernier Calliper. The difference in LCS on day 1 and day 10 was calculated for all groups. Results: Both cetirizine and levocetirizine were found to have significant analgesic action which was comparable to aspirin in...
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