Posted by admin on Jun 30, 2021 in |
The aim of this study was to synthesize the graft copolymer of starch to obtain materials that profit from the particular properties of both natural and synthetic polymeric material. Thus in the present work, a graft copolymer of methyl acrylate and potato starch has been synthesized under microwave irradiation using K2S2O8-TU redox pair, which generates free radical sites on the starch backbone where grafting will occur. MA was chosen as a co-monomer because of its known biocompatibility and non-toxic behavior together with ease of polymerization. Starch was modified through graft copolymerization of poly (methyl acrylate) under microwave irradiation using K2S2O8-TU redox pair. Different parameters were optimized to have a maximum yield of 390%. The effect of PMA grafting onto starch in respect of structural, mechanical, and other properties of grafted starch was investigated by FTIR, TGA, DSC, and SEM analysis. These copolymers could be used as biodegradable fillers and packaging material in the plastic industry. The graft copolymers, therefore, can help increase bioavailability. Due to the biodegradability of starch,...
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Posted by admin on Jun 30, 2021 in |
Background: Wound infection occurs when one or more organisms invade the wound. Nosocomial infections are the most common hospital acquired infections responsible for mortality and morbidity. Multidrug resistance against bacterial strains is the most serious emerging situation in worldwide, warranting the search for other alternatives. In this regard Pentabark kashaya was developed which contains ingredients possessing antimicrobial, anti inflammatory, and wound healing activity. Materials and Methods: Antibacterial activity of Pentabarkkashaya (PK) was determined against three predominant bacterial strains one gram positive and two gram negative strain Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The sensitivity of the organisms were tested by both the agar well method and broth dilution method (MIC) and it was compared with the antibacterial activity of provide iodine solution 5%. Result: Pentabark kashaya showed antibacterial activity against all the test pathogens in both agar well and broth dilution method. The highest antimicrobial activity was observed against Escherichia coli and Pseudomonas aeruginosa in agar well diffusion method showed the inhibitory zone of 14 mm in both...
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Posted by admin on Jun 30, 2021 in |
Common chicory (Cichorium intybus L.) plant belonging to sunflower family primarily grown for its root which is used as a coffee substitute but is also widely used in folk medicine to treat various ailments ranging from wounds to diabetes. The plant is a good tonic cooling agent and is useful in headache, throat inflammation, immune stimulation, mutagenic, probiotic, hepatoprotective, antibacterial activity etc., and these actions are attributed to a wide range of phytoconstituents present in this plant. In the existing study, the total flavonoid and phenol content of methanolic extract of selected parts (leaves, root, and seeds) of Cichorium intybus L.was quantitatively estimated using aluminium chloride colorimetric method (as quercetin equivalent) and Folin-Ciocalteu method (as caffeic acid equivalent) respectively. The total phenolic contents varied from 1.94± 0.895 to 1.66± 0.506 mg/gdw. Total flavonoid contents were between 1.60± 1.69 to 1.37 ± 0.796...
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Posted by admin on Jun 30, 2021 in |
Dolutegravir sodium (DTG) is a poorly soluble antiretroviral drug that belongs to BCS class II approved by the FDA for treatment of HIV infections; however, DTG has several shortcomings, including low solubility in water, low oral bioavailability, hepatotoxicity, and instability in an acidic environment. After oral administration, 84% of the dose is excreted from the body in an unchanged form due to its poor solubility. To overcome the above mentioned difficulties, Nano Lipid Carriers (NLCs) are selected as a potential drug delivery system for the present research work. NLC suspension was formulated using melt emulsification sonication technique using a combination of solid lipid (8% w/v), i.e., Glyceryl monostearate (GMS), Gelucire 50/13, Dynasan 118, and liquid lipid Capmul MCM EP along with a blend of Tween 80 and Span 80 as a surfactant, Sodium cholate (0.4 w/v) as surface charge modifier and BHT (0.01%w/v) as a preservative. Response surface methodology using 23 factorial designs with three independent variables, that is, lipid concentration (A), surfactant concentration (B), sonication time (C) was...
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Posted by admin on Jun 30, 2021 in |
Aim of the present research work was to develop a sensitive, precise, and robust stability-indicating UPLC method for the simultaneous estimation of tipiracil and trifluridine in formulations. The chromatographic separation of a mixture of tipiracil and trifluridine was attained in isocratic method utilizing a mobile phase of 0.1% orthophosphoric acid: acetonitrile in the proportion of 50:50% v/v utilizing a Hibera C18 column which has dimensions of 100 × 2.1 mm, 1.8µ particle size and the flow rate of 1.0 ml/min. The detection system was monitored at 230nm wavelength maximum with 1.5 µl injection volume. The retaining time for trifluridine and tipiracil was achieved at 0.549 min, and 1.251 min. respectively. Tipiracil and trifluridine and their combined drug formulation were exposed to thermal, acidic, oxidative, photolytic, and alkaline conditions. The present method was validated as per the guidelines given by the ICH for specificity, accuracy, sensitivity, linearity, and precision. The developed method was highly sensitive, rapid, precise, and accurate than the earlier reported methods. The total run time was decreased...
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