Posted by admin on Mar 31, 2021 in |
Ipomoea pes-tigridis (IP) is a twinning hairy herb grown in India. Based on the ethnopharmacological information of the plant, the ethanolic extract of the whole plant of Ipomoea pes-tigridis was evaluated for its anticonvulsant, antianxiety activity in mice. The Antiepileptic activity was assessed by using MES (maximal electroshock) model (200 and 400 mg/kg), and antianxiety activity was assessed by using the hole board and open field test. Bodyweight doses were used for the present study. In MES model, the ethanolic extracts showed a dose-dependent reduction in duration of the hind limb extensor phase when compared with the control group. It is evident that the mice which were treated with 400 mg/kg of EEIP (Ethanolic extract of Ipomoea pes-tigridis) showed a significant (P˂0.0001) effect in all the phases on MES induced convulsion. In HBT (hole board test), It was noted that the mice which were treated with 400 mg/kg of EEIP showed a high significance (P˂0.0001) effect on the number of head dipping due to the anxiolytic activity. In OFT...
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Posted by admin on Mar 31, 2021 in |
Diabetes mellitus is a metabolic disorder of the endocrine system and becoming a serious threat to mankind’s health in all parts of the world. Herbal remedies are considered convenient for management of diabetes due to their traditional acceptability, availability, and less side effects than oral hypoglycaemic agents. Thus, the present study aims to test the toxic and antidiabetic effect of a traditionally used herbal mixture of C. nilgiriensis and P. marsupium in STZ induced diabetic rats. No mortality, abnormal behaviour, and physiological changes were noted in all doses of herbal mixture treated rats and did not cause any toxic oriented effects even in the high dose during toxicity studies. Thus 200 mg/kg bwt dose of the herbal mixture was selected to evaluate their antidiabetic activity. Herbal mixture treated rats exhibited a significant reduction in blood glucose level (One way ANOVA, f3,12 =525.78; p<0.005), HbA1c level (One way ANOVA, f3,12= 87.35; p<0.005), and a significant increase in serum insulin level (One way ANOVA, f3,12=418.0; p<0.005). The herbal mixture also proved...
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Posted by admin on Mar 31, 2021 in |
Malaria is a parasitic infectious disease transmitted through the bite of female Anopheles mosquitos. Every year, approximately 210 million Peoples are suffering from this dangerous disease, and around 440,000 individuals pass from this infectious disease. Recently, the Indonesia Ministry of Health declared that the malaria pre-elimination stage should be reached by 2020 and be free of malaria transmission by 2030 to achieve the goal of an Asia-Pacific free of malaria by 2030. So, this study focused on the discovery of novel anti-malarial and medication targets against malaria. The three-dimensional (3D) structures of PFHGPRT, HSHGPRT, and TCHGPRT were used for comparative docking study, while two inhibitors 6-(2, 2-Dichloro-acetamido) chrysene and GMP-2′, 3′-dialdehyde were used as a lead for designing and discovery of potential inhibitor of PFHGPRT with the help of various software. The three-dimensional structure (3D) of pfHGPRT (3OZF) and (4RAO) PfHGPRT was isolated from its intricate structure and was utilized for docking study, and comparably, HsHGPRT was isolated from its perplexing structure, and it also utilized for docking study....
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Posted by admin on Mar 31, 2021 in |
The present research work was intended to develop and characterize the transdermal adhesive patch of clozapine using different types of acrylate, polyisobutylene and silicon adhesives. Various permeation enhancers such as 1, 8 – cineole, D-limonene, Azone, IPM and Oleic acid were also evaluated to achieve desired permeation rate and hence to attain the improved bioavailability as compared to oral formulation. Formulation prepared were evaluated for physicochemical characterization, FTIR, DSC, permeability enhancement potential by ex-vivo, and stability studies. The results of the optimized formulation showed peel strength of 411 ± 3.56 cN/cm, flux of 109.59 ± 1.59 (µg/h/cm2) and % drug content of 99.53 ± 0.42% which was stable up to six months in accelerated condition. The results of the study revealed that the developed transdermal patch of clozapine can be a promising alternative which provides effective management of schizophrenia in terms of improved patient compliance and bioavailability which in turn reduces the dosage frequency and hurdles associated with the caretakers and...
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Posted by admin on Mar 31, 2021 in |
The main objective of the study is to develop gelucire 44/14 based lapatinib ditosylate (LPT) SNEDDS for the improvement of solubility and drug release. Pseudo tertiary phase diagram constructed for varying oil, surfactant, and co-surfactant combinations. Fifteen LPT SNEDDS formulations were prepared with anticipated component ratios (gelucire 44/14, peceol, and capmul MCM) based on monophasic region are subjected to thermodynamic physical stability test. Formulations that cleared stability tests were evaluated for % transmission, drug content, and in-vitro drug release analysis. The optimized formulation analyzed for particle size and zeta potential, followed by FTIR and SEM analysis. Formulation F13 with a maximum drug release of 98.96% in 60 min higher than 38.90±3.25% of pure drug is considered an optimized formulation. The average particle size and zeta potential of the F13 were 72.5 nm and -13.4 mV, respectively. The FTIR and SEM studies do not indicate any drug excipient interaction and confirm uniform drug distribution. The formulation subjected to accelerated stability study is proved to be stable over a period of...
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