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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

IJPSR is indexed with Embase

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Posted by on Dec 31, 2020 in |

ESTIMATION OF TOTAL PHENOLIC AND FLAVONOID CONTENT OF SOME CUCURBIT FRUIT PEELS AND IN-VITRO EVALUATION OF THEIR METHANOLIC EXTRACTS FOR ANTIOXIDANT POTENTIAL

Objective: To analyze In vitro antioxidant activity, total phenolic and flavonoid content of methanolic extract of some cucurbit fruit peels. Methods: Phytochemical screening of extracts was carried out. Aluminium chloride colorimetric method was used to estimate TFC (total flavonoid content), and TPC (total phenolic content) was measured by Folin-ciocalteu method. Two different assays- DPPH free radical scavenging and FRAP were used for the determination of antioxidant activity. Results: The total phenolic content was found to be maximum in Cucumis melo i.e. 42.64 ± 0.85 mg GAE/gdw, and minimum in Cucumis sativus i.e. 8.52 ± 0.74 mg GAE/gdw. Total flavonoid content was found to be maximum in Cucumis melo i.e. 4.71 ± 0.67 mg QE/gdw and minimum in Citrullus lanatus i.e., 0.74 ± 0.31 mgQE/gdw. Results of DPPH Scavenging activity and FRAP assay revealed that all the peel samples had a significant antioxidant potential, where Cucumis melo show the highest antioxidant potential. Conclusions: Results of the present study showed that the selected fruit peels of cucurbit family have bioactive compounds...

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Posted by on Dec 31, 2020 in |

EVALUATION OF WOUND HEALING ACTIVITY OF HYDROALCOHOLIC EXTRACT OF FICUS GLOMERATA ON WISTAR ALBINO RATS

Traditionally, Ficus glomerata is used for wound healing activity. Since no detailed scientific data are available regarding the wound-healing activity of F. glomerata, the present study was designed to explore the effect of hydro-alcoholic leaf extract of Ficus glomerata (HEFG) on experimentally induced excision and incision wound models in Wistar rats. The wound-healing efficacy of Hydroalcoholic extracts of F. glomerata was evaluated in excision and incision wound models by topically applying the Hydroalcoholic extract in the form of ointment as per Indian Pharmacopoeia. The extract was formulated in ointment base at concentrations of 5% and 10% and topically applied to the wounds. In the excision and incision wound model, topical application of different concentrations of Ficus glomerata extract ointment (5% and 10% w/w extract in the simple ointment) has shown a high rate of wound contraction and decrease in the period of epithelisation time and improved the tensile strength to a greater extent when compared to control (simple ointment treated) group. The 10% extract ointment treated group demonstrated greater wound-healing promoting property...

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Posted by on Dec 31, 2020 in |

GC-MS ANALYSIS OF OIL FROM LAVANDULA LATIFOLIA L. AND ITS REPELLENT ACTIVITY AGAINST MOSQUITO

Mosquitoes are one of the important vectors of various diseases. Repellent activity significantly reduces contact with disease-transmitting mosquitoes. Essential oils have repellent activity that is being potentially developed as an alternative to commercial chemical pesticides. In this study, Lavandula angustifolia was used to evaluate its repellent activity against Ae. Aegypti. The repellent activity of L. angustifolia oil was tested with the 100, 200, 300, 400, and 500 ppm concentrations against the adult mosquitoes of Ae. Aegypti. L. angustifolia showed 100% protection up to 150 minutes against the bite of Ae. aegypti. After that, the repellency was found reduced by the increased exposure periods against Ae. Aegypti. The presence of phytochemicals in oils could be responsible for different mosquitocidal agents. Lavender oil was subjected to GC-MS analysis. It showed the presence of  37 compounds, including, 1R-à-Pinene, Bicyclo[2.2.1]heptane, 2,2-dimethyl-5methylene-, Tricyclo[2.2.1.0 (2,6)]heptane, 1,7,7-trimethyl-, Ocimene, Camphene, á-Pinene, Cyclohexene, 4-methylene-1-(1-methylethyl)-, Eucalyptol, 1,4-Cyclohexadiene, 1-methyl-4-(1-methylethyl)-, Bicyclo [2.2.1]heptan-2-one, 1,3,3-trimethyl-, 3-Oxatricyclo[4.1.1.0(2,4)] octane, 2,7,7trimethyl-, Acetaldehyde, (3,3-dimethylcyclohexylidene)-, (E)-, Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1S)-, Isoborneol, Borneol, Cyclohexanol, 1-methyl-4-(1-methylethylidene)-, Tetra-cyclo[6.3.2.0(2,5).0(1,8)]tridecan-9-ol, 4,4-dimethyl-, 1,6,10,14-Hexadecatetraen-3-ol, 3,7,11,15-tetramethyl-, (E,E)-...

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Posted by on Dec 31, 2020 in |

ANTI-CANCER POTENTIAL OF MORUSINDICA HYBRID VARIETIES IN HT-29 CANCER CELL LINES: AN EXPLORATORY STUDY

Complementary alternative medicine focuses on discovering the potential of plants in prevention and management of chronic diseases. Although Morus species has been screened for various biological activities, studies reporting the pharmacological effects of Morus indica (MI) hybrid varieties viz., V1 and S36 is scarce. This study focused on screening the phytochemical composition of Morus indica V1 (MV1) and Morus indica S36 (MS36) and evaluate its antioxidant and anti-cancer potential. The qualitative analyses revealed the presence of all major phytochemicals except alkaloids. The results of the quantitative analyses showed a better phytochemical profile in MV1 than MS36 and the values differed significantly (p<0.05). The antioxidant activity was higher in methanol extracts of both the MI varieties followed by ethanol and aqueous extracts since the extractability of phytochemicals are higher in organic solvents. MV1 had a better phytochemical profile compared to MS36 and therefore was selected for screening the in-vitro anti-cancer properties. Among the methanol and aqueous extract of MV1, aqueous extract had the lowest IC50 value viz., 55 µg/mL. The...

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Posted by on Dec 31, 2020 in |

COMPARATIVE INVESTIGATION OF TOXICOLOGICAL CHARACTERISTIC AND SPECIFIC BIOLOGICAL ACTIVITY OF THE MEDIUM-CHAIN ALIPHATIC MONO- AND DIPEROXYCARBOXYLIC ACIDS

The comparative toxicological characteristic in-vitro and antimicrobial activity to perform stability tests of several linear medium-chain aliphatic monoperoxyacids (perC8–C12) and aliphatic diperoxyacid (diperC9) were studied. Substances of peroxide acids: perС8, perС10, perС12, diperoxyazelaic acid (diperC9) are in 5.6; 22.8; 64 and 1.6 times less toxic than reference substance – peracetic acid (perC2). New knowledge concerning а comparative antimicrobial activity of studied medium-chain aliphatic peracids and their thermal sensitivity was obtained. These fundamental stability studies resulted in the emergence of safe antimicrobic agents. Nonanebis(peroxoic acid) and Peroxyoctanoic acid were proposed as an agent in the chemical disinfection prosses for the first time. Medium-chain aliphatic peracids were demonstrated to be very robust. Sufficiently high bactericidal activity was achieved after relatively short exposition times (from 10 min to 2 h for spores of B. anthracoid), at near-ambient temperature (20 °C). In this work, it has been demonstrated how stability studies can underpin rational design of antimicrobic agents that in turn lead to a both safer and economically viable chemical disinfection and sterilization...

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