Posted by admin on Jan 31, 2021 in |
The study was initiated to determine the antidaibetic activity of Avicennia alba in Streptozotocin induced Type-2 diabetic rats. The rats were treated with 100, 200 and 400 mg/kg of Avicennia alba stem and leaf methanolic extract (MLAA) and compared with the diabetic, normal and standard (glibenclamide) rat groups. The blood glucose levels, glycosylated haemoglobin levels, and body weight of the rats in different groups (n=6) were monitored at 0, 7, 14 21, and 28 days. The histopathological parameters of the liver and pancreas were also analyzed at the end of the study. MLAA (100, 200, and 400 mg/kg) extract reduced the blood glucose level from the 21st day itself (193, 141, and 134 mg/dL), and the best reduction was observed by the end of the study with 121.3 and 107.3 mg/dL (200 and 400 mg/kg). The initial decrease in body weight was recovered after the drug treatment, and normalization in body weight was observed on the 4th week. The glycosylated haemoglobin was found normal in MLAA (200 and 400...
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Posted by admin on Jan 31, 2021 in |
The objective of the current study is to investigate the hepatoprotective activity of Cinnamomum zeylanicum bark (CZB) extract on acetaminophen-induced hepatotoxicity in albino rats. Wistar albino rats (150-200 g) of either sex were divided into six groups, and toxicity was induced by acetaminophen (APAP) at a dose of 750 mg/kg, bw, p.o, every 72 h, for two weeks. Silymarin (100 mg/kg, p.o) was given as reference standard. CZB (100 mg/kg and 200 mg/kg, p.o) was tested for hepatoprotective activity. Various serum parameters like alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatise (ALP), total Bilirubin (TB), total protein (TP), albumin (ALB), and total cholesterol (TC) in different groups were measured. Further, the effect of the extract on super oxide dismutase, catalase, reduced glutathione, and lipid peroxidation were also estimated. The treatment with ethanolic extract of CZB reduced the elevated levels of AST, ALT, ALP, TB, and TC and also reversed the hepatic damage as compared with toxic control rats. A decreased level of ALB and TP was also significantly restored...
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Posted by admin on Jan 31, 2021 in |
Rutin trihydrate a herbal drug having abundant medicinal properties, mainly used for topical treatment of inflammation, presents a hindrance and reduced anti-inflammatory activity. It is BCS class II drug having low oral bioavailability, poor water solubility (0.125 g/L), and low stability of rutin in aqueous alkaline medium, restricting its application in use. So, it is successfully formulated as an emulgel to improve its anti-inflammatory properties. The current study aims to design, formulate, and optimize Rutin trihydrate emulgel to enhance its efficacy and stability. Emulgel was designed, optimized by using a central composite design taking three independent variables and one dependent variable. Five responses were generated, and the optimized formulation was prepared using carbopol 934(0.8%), clove oil (12.5 ml), and span (2.32%). The emulsifying agent being Tween 20, Span 20, and the preservatives used are methyl and propyl parabens. The formulation (F2) with this combination gave emulgel of yellow color, homogeneous with good consistency, possessed pH of 6.51 ± 0.04, drug content of 98.7%, the viscosity of 14, 980 cps,...
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Posted by admin on Jan 31, 2021 in |
This paper examined the liquisolid compact method as one of the tools for greater dissolution of the practically water-insoluble drug famotidine (FM). Therefore, the model drug, FM, has been formulated as directly compacted tablets and liquisolid compacts and then investigated for in-vitro release properties at diverse dissolution circumstances. According to the method, it is possible to convert the liquid medications of water-insoluble drugs in the non-volatile liquid vehicles into reasonably compressible and flowing powders. The formulated systems have been evaluated in terms of the pre-compression factors like the Fourier-transform infrared spectroscopy (FTIR) analysis, flow features of the liquisolid system, differential scanning calorimetry (DSC), post-compression factors, including the content uniformity, hardness, friability and weight variation, disintegration test, in-vitro dissolution examinations, effects of the dissolution volume as well as pH on the drug release rate and approximation of the fraction of the molecularly dispersed drug in the liquid medication. Since, the liquisolid compacts revealed notably greater drug release rates in comparison to the direct compress tablets in diverse dissolution volumes and...
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Posted by admin on Jan 31, 2021 in |
In recent years, the extensive use of antibiotics has resulted in their frequent detection in the effluent discharge of wastewater discharge plants (WWTPs). In this study, the feasibility of using Surfactant-Modified Kaolinite (SMK) to remove the antibiotic, Ciprofloxacin (CIP) from wastewater was evaluated from batch experiments. The batch adsorption system was utilized to evaluate the CIP removal efficiency at different contact times, SMK dosages, and CIP concentrations. The experimental data were analyzed by the Langmuir, Freundlich, Temkin, and Dubinin–Radushkevich (D–R) isotherm models. R2 values of Langmuir and D–R isotherm models are higher than that of other models, and maximum monolayer coverage (qmax) was calculated as 61.82 mg/g. The separation factor of 0.495 indicated favorable sorption. Also, from the Freundlich isotherm model, the intensity of adsorption (n) that indicated favorable sorption was 2.954. The kinetic study of sorption indicates that the pseudo-second-order model provides a better correlation of the sorption data than the pseudo-first-order, confirming the chemisorption of CIP ions on SMK. The results showed that a significant increase in...
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