Posted by admin on Nov 30, 2020 in |
Objective: The goal of the present examination was to investigate anti-diabetic activity of Azima tetracantha Lam. leaves in streptozotocin-induced diabetic rats. Materials and Method: At a regular interval of an experimental protocol, blood glucose, insulin, glycogen, HDL, LDL, VLDL, FFA, PL, and TC and organs to bodyweight proportion were assessed in streptozotocin-induced diabetic rats. Histology of the pancreas and liver was also studied. The statistical analysis of streptozotocin-induced diabetic rats was observed in accordance to 4, 15, 30, 45, 60 days. Results: A significant decrease in blood glucose and a significant increase in insulin and glycogen were observed in diabetic rats treated with A. tetracantha Lam. treatment resulted in a significant reduction of LDL, VLDL, FFA, TC while increased HDL content is observed. Histology of diabetic rats treated with A. tetracantha Lam. showed the pancreatic β-cells regeneration. Conclusion: These findings suggest that A. tetracantha Lam. has potent anti-diabetic activity in streptozotocin-induced diabetic...
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Posted by admin on Nov 30, 2020 in |
Medicinal plants are widely used to treat disease in non-industrialized societies for not being far cheaper than modern medicines. In this study, five types of medicinal plants viz., Glycyrrhiza glabra, Aegle marmelos, Centella asiatica, Cinnamomum verum, Cynodon dactylon were collected from Alwarkurichi, Tirunelveli District, Tamil Nadu, and extracts were prepared using various solvents such as methanol, ethanol, chloroform, diethyl ether, benzene, and water. These extracts were checked for antibacterial activity against Staphylococcus aureus isolated from a hospital environment. On the basis of antibacterial activity, three plants viz., Glycyrrhiza glabra, Aegle marmelos, and Centella asiatica were chosen for further research in which the ethanolic extract of Glycyrrhiza glabra rendered higher activity against Staphylococcus aureus. Thin Layer Chromatography of the plant extract of Glycyrrhiza glabra was carried out, which showed the development of four bands of which the first three bands rendered higher sensitivity against Staphylococcus aureus. The eluted bands from TLC were visualized under the UV-Spectrophotometer to monitor the absorbance of the eluted three bands in the wavelength spectrum ranging...
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Posted by admin on Nov 30, 2020 in |
Highly bioactive ultra-small vancomycin doped silver nanoparticles were synthesized by the sol-gel method. The samples were characterized by UV, FR-IR, XRD, Photoluminescence, and TEM analysis. Continuous stirring helped in preparing ultra-small drug conjugate silver nanoparticles. Observation of weak (broadened peak) in XRD diffractograms indicates the formation of very small size drug conjugate sliver nanoparticles. Doping of Vancomycin drug improves the antibacterial activities of silver nanoparticles in the serial dilution method and results in strong yellow, green, and blue luminescence peaks. Antibacterial assay showed that sliver nanoparticles conjugation with vancomycin drug enhanced the antibacterial activity against a variety of gram-positive bacteria like E. coli, S. aureus, and Enterococcus faecalis. These findings suggest that modifying clinically approved drugs using nanotechnology is a feasible approach in our work for effective antibacterial molecules. The results of this study revealed that the potential therapeutic applications of silver nanoparticles in combination with vancomycin antibiotic had been increased drastically. Nanosilver with antibiotic is a promising candidate for the development of future antibacterial therapies because of its...
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Posted by admin on Nov 30, 2020 in |
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in edible plants. Chalcone metal complexes and their derivatives have been known over the past fifty years. Copper is an essential element, and hence it is used to synthesize metal complexes. Copper possesses a broad spectrum of activity and a higher DNA binding ability when compared to platinum drugs. The metal-based drugs may range from natural products to artificial organic molecules. Their exceptional magnetic optical radioactive are used in many non-invasive methods like magnetic resonance imaging (MRI), position emission tomography (PET), optical imaging. Copper-based metal complexes have been studied extensively towards DNA interaction aspects. The binding ability of the complexes has been explored based on the results of DNA binding studies assessed by different spectroscopic techniques like UV absorption titration. Thus, we are reporting DNA interaction studies using UV spectroscopic...
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Posted by admin on Nov 30, 2020 in |
Osmotic tablets have emerged as a new technology for the delivery of drugs whose release rate is to be controlled. These tablets offer controlled drug release with the help of certain osmogens and also provide zero-order rate kinetics. In the present study, we have developed an osmotic tablet of Metformin Hydrochloride (HCL) to enhance its oral bioavailability. Metformin HCL is a biguanide derivative often used as an anti-hyperglycemic agent. The tablets were prepared using the wet granulation technique. The prepared formulations were characterized and optimized on the basis of various physicochemical properties, and F5 was selected as best. The in vitro drug release study demonstrated that the drug release depends upon the concentration of different polymers, including hydroxyl propyl methylcellulose (HPMC) and Poly ox N80 (polyethylene oxide). A higher concentration of HPMC and Poly ox N80 results in drug release for extended duration. The optimized formulation developed with a 3:1 ratio of both the polymers HPMC E5 and Poly ox N80 have shown nearly 86% of drug release. Osmotic...
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