Posted by admin on Nov 30, 2020 in |
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in edible plants. Chalcone metal complexes and their derivatives have been known over the past fifty years. Copper is an essential element, and hence it is used to synthesize metal complexes. Copper possesses a broad spectrum of activity and a higher DNA binding ability when compared to platinum drugs. The metal-based drugs may range from natural products to artificial organic molecules. Their exceptional magnetic optical radioactive are used in many non-invasive methods like magnetic resonance imaging (MRI), position emission tomography (PET), optical imaging. Copper-based metal complexes have been studied extensively towards DNA interaction aspects. The binding ability of the complexes has been explored based on the results of DNA binding studies assessed by different spectroscopic techniques like UV absorption titration. Thus, we are reporting DNA interaction studies using UV spectroscopic...
Read More
Posted by admin on Nov 30, 2020 in |
Osmotic tablets have emerged as a new technology for the delivery of drugs whose release rate is to be controlled. These tablets offer controlled drug release with the help of certain osmogens and also provide zero-order rate kinetics. In the present study, we have developed an osmotic tablet of Metformin Hydrochloride (HCL) to enhance its oral bioavailability. Metformin HCL is a biguanide derivative often used as an anti-hyperglycemic agent. The tablets were prepared using the wet granulation technique. The prepared formulations were characterized and optimized on the basis of various physicochemical properties, and F5 was selected as best. The in vitro drug release study demonstrated that the drug release depends upon the concentration of different polymers, including hydroxyl propyl methylcellulose (HPMC) and Poly ox N80 (polyethylene oxide). A higher concentration of HPMC and Poly ox N80 results in drug release for extended duration. The optimized formulation developed with a 3:1 ratio of both the polymers HPMC E5 and Poly ox N80 have shown nearly 86% of drug release. Osmotic...
Read More
Posted by admin on Nov 30, 2020 in |
Solanum torvum Sw. belonging to the family Solanaceae is locally called as pea eggplant, sundai and cherry egg-plant in India. The fruits of Solanum torvum Sw. used to cure diseases of the diuretic, malaria, stomach aches, problems with the spleen, treat coughs, improve the eyesight, treats headaches which attribute many properties in Ayurveda, siddha, unani and local health traditions. The purpose of this study is to isolate and characterize the STL, STB and STD from the fruits of Solanum torvum Sw. The isolation was done using column chromatography using gradient elution with different mobile phase. Structural elucidation of the isolated compounds was established out on the basis of elemental analysis and spectroscopic evidence of IR, 1H NMR, 13C NMR spectra. The purification of the isolated compounds by HPLC and HPTLC was carried out. On the basis of the spectral data and chemical reactions, the compounds have been established as STL, STB, and STD are being reported from this plant for the first...
Read More
Posted by admin on Nov 30, 2020 in |
Degradation studies are essential to determine the inference of degradation routes and stability of pharmaceuticals at different stress conditions. Norfloxacin is an extensively used antibiotics; hence, it is also commonly found in wastewater effluent. For proper risk assessment of norfloxacin and for better understanding of the factors involved in its environmental fate, different factors were studied which were involved in the degradation of norfloxacin. Effect on degradation was studied for three factors, i.e., time (24 h, 48 h, and 72 h), temperature (30°, 45°, and 70°), and concentration of oxidant (1% H2O2, 3% H2O2, and 5% H2O2) at three different levels using Design of experiment (DoE) approach. Absorbance was selected as a response that would signify the extent of degradation of the drug. It was observed that all three factors were involved in degradation but when the factors are studied one at a time, the effect of temperature and concentration of oxidant was more significant and time has a very small effect on the degradation of norfloxacin. When multiple...
Read More
Posted by admin on Nov 30, 2020 in |
Repaglinide, a blood-glucose-lowering drug, has low oral bioavailability (56 %) due to first-pass metabolism and shorter half-life (~1 hour) lead to frequent dosing to control blood glucose level. Repaglinide Transdermal Therapeutic System (TTS) was prepared to provide continuous drug delivery for a prolonged period of time. Factors affecting critical quality attributes (CQA) of Repaglinide TTS are optimization of drug load in the adhesive matrix, selection of design, selection of permeation enhancer, matrix thickness, optimization adhesive characteristics, and optimization of delivery rate for a prolonged period of the time. In this research, the impact of critical material attributes (CMA), for example, the concentration of API and permeation enhancers, were studied on CQA like drug delivery and adhesive performance of the product using optimal full factorial design. Moreover, critical process parameters (CPP) were identified using the response surface method, and the impact of identified CPP (drying temperature) on CQA (residual solvents) was evaluated. The results of the design of the experiments study indicate a significant impact of API and permeation enhancer...
Read More
