Posted by admin on Nov 30, 2020 in |
A benzoin derivative of 2-Semicarbazono-1-hydroxy, 1-[2-chlorophenyl]-2-[4′-methoxyphenyl] ethane (2C4MBS) was synthesized by benzoin condensation followed by addition reaction. The structure elucidation done using single XRD studies. Maximal electroshock seizure (MES) model was used in the present study to evaluate the anticonvulsant activity of the test drugs. MES seizures were induced by an electro convulsiometer by delivering electroshock of 60 mA current transauricularly for 0.2 sec in mice using corneal electrodes. The incidence and duration of the extensor tonus were noted. Phenotyin is used as standard, synthesized drugs of 5 and 10 mg/Kg were subjected in test animals. The duration of the tonic hind leg extension phase of MES convulsions expressed as the arithmetic mean ± SE and was analyzed by one-way analysis of variance (ANOVA) followed by Dunnet′s ′t′ test. Data were analyzed using one-way analysis of variance (ANOVA), and group means were compared using the Multiple Comparison test using Instat-V3 software. P values < 0.05 were considered significant. Hematological and blood biochemical analyses also performed, and the results revealed...
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Posted by admin on Nov 30, 2020 in |
In this work, the molecular structure optimization, electronic properties like local chemical reactivity descriptors (Fukui function analysis for reactive site prediction), and thermodynamic properties (Heat capacity, entropy, zero points vibrational energy, thermal energy, translational, rotational and vibrational energy) of antifungal drugs were theoretically computed. In this work also, electronic structure, frontier molecular orbital energies (HOMO-LUMO gap for the chemical activity of drug), molecular electrostatic potential (useful for recognizing electrophilic and nucleophilic attack) and mulliken charge has been carried out. Atomic charges dipole moment, molecular polarizability, electronic parameter, and refractivity of molecular systems were calculated by the DFT method. The reactive site prediction and hydrogen bond interaction analysis was determined by using the Fukui function analysis. In this study, DFT/B3LYP/6-31+G and DFT/CAM-B3LYP/6-31+G (d, p) methods were...
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Posted by admin on Nov 30, 2020 in |
Objective: Arjunarishta is an important Ayurvedic formulation with chief ingredient Arjuna (Terminalia arjuna), which is excellent “Hrudya” Dravya. It nourishes & strengthens heart muscles & promotes cardiac functioning by regulating blood pressure and cholesterol level. This study aims to established quality parameters for standardization of Ayurvedic formulation “Arjunarishta” on the basis of various techniques viz. Physico-chemical screening, Chromatography & IR Spectroscopy. Method: Conventional analysis such as Organoleptic tests, pH, Alcohol content, Brix, and Specific gravity was done. Chromatographic analysis was performed to estimate Arjungenin, Ellagic acid, and Gallic acid using High-Performance Thin Layer Chromatography (HPTLC). IR fingerprint was done using Fourier transform infrared (FT-IR) spectrometer. Result: The above analysis showed the pH of tested formulation ranges between 3.0-5.0, Brix 25-30%, and Alcohol content 6-10% v/v. Organoleptic tests confirmed characteristic odor of self-generated alcohol with sweet, astringent & slightly bitter taste. HPTLC analysis confirmed the presence of Arjungenin, Ellagic acid, and Gallic acid. FT-IR reveals unique transmittance spectra in the range of 4000 – 600 cm-1. Conclusion: This study can...
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Posted by admin on Nov 30, 2020 in |
The extracts of Boswellia serrata possess notable medicinal uses. Boswellia serrata is a highly lipophilic drug. It undergoes extensive hepatic first-pass metabolism. The t1/2 is approximately 6 h. There are reported side effects with the administration of Boswellia serrata. This research work aims to fabricate Elastosomes which get hold of many desired features for transdermal drug delivery. The Elastosomes are prepared using thin-film hydration technique using edge activators like Span 80, Tween 80, and Brij 30. The prepared elastosomes are evaluated for entrapment efficiency percentage (EE %), particle size (PS), polydispersity index (PDI), zeta potential (ZP), deformability index (DI), drug release study, and permeation study. EF-10 was regarded as the optimized formulation with all the desired characteristics. The optimized formulation (EF-10) resulted in better prolong drug release and sustained therapeutic action as compared to the marketed...
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Posted by admin on Nov 30, 2020 in |
Increasing severity of the disease osteoporosis in postmenopausal women with long term exposure to pharmacotherapy has spurred interest in the development of using food as medicine and phyto-pharmacotherapy. We examined the effect of n-hexane crude leaves extract and its nanoparticle formulation of Sesbania grandiflora in cell proliferation and bone mineralization at different concentrations in Saos-2 cell line. Osteogenic differentiation and cell viability of Saos-2 cells were quantified by monitoring alkaline phosphatase activity and MTT assay. HPLC analysis confirms the presence of bioactive compound α tocopherol. It was found that the concentrations 10 µg & 20 µg/100 µL significantly induced cell proliferation (p<0.05), and the expression of ALP (p<0.01) was not inhibited by the presence of the bioactive compound. Our data suggest that S. grandiflora nanoparticles affect the Saos-2 cell health in higher dose concentration and will be a good natural herbal medicine candidate for the treatment of osteoporosis at lower dose concentration. Further research is required to gain insight into the plant bioactive compounds and the molecular mechanism involved...
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