Posted by admin on Oct 31, 2020 in |
Better patient compliance can be achieved using a combination of two drugs compared to a single drug. The main objective of the present research work has been done to prepare fast dissolving tablets of Nebivolol HCl (NEB) and Valsartan (VAL) using super disintegrating agents. Solid dispersions of VAL were prepared with Mannitol to improve the solubility and release behavior in dissolution fluid. Fast Dissolving tablets of NEB and VAL were formulated by employing the direct compression method. The prepared fast dissolving tablets were evaluated for various parameters like weight variation, hardness, friability, disintegration time, drug content, wetting time, in-vitro drug release, FTIR, DSC studies and short term stability studies. It was found that ratio 1:1 (VAL: Mannitol) shown satisfactory drug release compared to other prepared solid dispersion. Pre-formulation studies of both drugs were performed. The FTIR and DSC studies revealed that there is no chemical interaction with excipients. Percentage weight variation and drug content uniformity were found to be within the approved range of all the formulations. Evaluation parameters like hardness and friability indicated good mechanical resistance of...
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Posted by admin on Oct 31, 2020 in |
Helicobacter pylori is a major etiological agent responsible for several gastric diseases such as gastritis, peptic ulcer disease, and gastric cancer. From the last two decades, standard triple therapy is mostly recommended for H. pylori eradication; however, its efficacy is restricted by antibiotic resistance. Hence, the present study aimed at exploration for novel therapeutic agents being warranted to overcome antibiotic-associated limitations in the current H. pylori eradication regimens. H. pylori DSMZ 10242 was procured and maintained at standard conditions. Anti-microbial assays were performed (in triplicates) to determine the susceptibility of this gastric pathogen to the selected probiotic formulations (Darolac-Z, Pre-Pro, Sporlac, VSL#3, and Yakult) and commonly prescribed antibiotics. The study convincingly reports that Darolac-Z containing Lactobacillus rhamnosus and Saccharomyces boulardii possess stronger anti-H. pylori activity (24.17 mm in 20 h of incubation) in comparison to other probiotics and antibiotics (maximum inhibitory zone observed is 18.4 mm after 48 h of incubation in case of amoxicillin). The probiotic supplementation containing L. rhamnosus and S. boulardii has a synergistic effect on...
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Posted by admin on Oct 31, 2020 in |
A new stability-indicating high-performance liquid chromatographic method of analysis of capecitabine in pharmaceutical dosage form was developed and validated. The solvent system consisted of methanol: water (60:40% v/v). The retention time of capecitabine was 7.927 min at a flow rate of 1 ml/min on C-18 (Quails BDS, 250 × 4.6 mm, 5µ). Capecitabine was detected at 240 nm. The linear regression analysis data for the linearity plot showed good linear relationship with the correlation coefficient value, R2 = 0.9991 in the concentration range 4-50 µg/ml. The method was validated according to the ICH guidelines. The accuracy of the method was validated by recovery studies and was found to be significant and under specification limits, with Recovery 98.12-101.61%. The assay of capecitabine was determined in tablet dosage form. The method was also found to be robust. The drug was subjected to stress conditions of acidic, basic, oxidation, photolytic and thermal degradation, and considerable degradation was found in all stress conditions. The method has proven specificity for the stability-indicating method....
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Posted by admin on Oct 31, 2020 in |
Herbs have been used since antiquity for treatment and management of various disease conditions. Their ability to cure or prevent diseases is due to storehouses of various phytoconstituents like alkaloids, flavonoids, glycosides, terpenoids, steroids, tannins, phenols, etc. present in them. Pentacyclic triterpenoids have gained greater attention of researchers due to its wide array of pharmacological actions. Thus, a simple and precise HPTLC method has been developed for identification and quantification of one such ubiquitous pentacyclic triterpenoid- ursolic acid in the leaves of Alstonia scholaris. The optimized mobile phase Toluene: Ethylacetate (7:3v/v) gave a better resolution of bands of ursolic acid at 540 nm after derivatizing plate with ASR. The Rf value for ursolic acid was found to be 0.46. The amount of ursolic acid quantified in ethanol, and chloroform extracts of leaves of Alstonia scholaris were 2.34 and 2.38 %w/w, respectively. The developed method was validated in terms of linearity, range, specificity, precision, accuracy, LOD, and LOQ following ICH guidelines. The calibration curve of ursolic acid was linear between...
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Posted by admin on Oct 31, 2020 in |
1-{3-[2, 3dihydro-1H-imidazol-1-yl (8-hydroxyquinolin-7-yl) methyl] phenyl-l} ethanon, nitrogen and oxygen-based bi-dentate mannich base heterocyclic ligand synthesized and complexed with biologically significant transition metals like copper, cobalt, nickel, and zinc by the melt condensation three-component one-pot synthesis. All the synthesized potential compounds characterized by spectral methods by using NMR, IR, UV-visible mass, and elemental analysis. The antimicrobial analysis investigated for all the synthesized compounds using some bacterial and fungal cultures used by the disc diffusion method, and the activity proved in proportion with the standard drugs used as a reference. The main significant part of the work involved in mannich base reaction of one-pot synthesis three-component reactions prove better synthetic procedure and improved product yield. The ligand and the complexes of transition metals proved better microbial activities of biologically important and to prove the efficiency of the present work. Continuation of research work is to investigate significant heterocyclic molecules and transition metal complexes to prove potential microbial activities play an important role in pharmaceutical and biological...
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