Posted by admin on Oct 31, 2020 in |
In the modern lifestyle, people are prone to disease. The epidemiology study shows that the lung and colon cancer leading position in both the gender around the world at any group. As based on the traditional systems of medicine, the plants can be used for the discovery of new medicine. The aqueous and ethanol extract of Nigella sativa (N. sativa) seeds were evaluated for their genotoxicity using Ames test and cytotoxicity by MTT assay. Ames assay was conducted using strains of Salmonella typhimurium TA-100, whereas MTT assay was performed on human alveolar basal epithelial cells (A549) and human colon cancer cell line (HCT15). There is no mutagenic activity was obtained when treated with aqueous and ethanol extract of Nigella sativa seeds. But both the extracts were found to be cytotoxic against the tested cancer cell lines. On the basis of the results, it was concluded that aqueous and ethanol extracts of Nigella sativa seeds possess cytotoxic potential but not mutagenic. It is suggested to explore the seeds further to...
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Posted by admin on Oct 31, 2020 in |
Zinc oxide-magnesium has been used in dentistry with limitations especially related to its high acidity and low biocompatibility. The objective of this study was to develop cement based on nano-hydroxyapatite (nHA), chitosan as more biocompatibility agents to increase zinc oxide-magnesium cito-compatibility. The formulations prepared were: 1. Complete cement (HCP) with nHA, zinc oxide-magnesium, and chitosan; 2. cement without nHA (CP); 3. Without chitosan (HP); 4. Without zinc oxide-magnesium (HC), and CPZn as control. All cement were compared for setting times, solubility, contact angle, pH, calcium ion release, shear strength, the thermogravimetry analysis, X-ray diffraction, Raman spectroscopy, 3T3-L1 fibroblasts cell compatibility, and antimicrobial activity. The results showed that HCP cement had setting time (mean ± S.D) of 5.5 ± 0.18 min, (p≥0.05) and neutral pH values on 14 days, calcium release of 10 mgL-1, and solubility with a value of 2.15%. The physicochemical characterization showed an expected pattern from the raw materials and composition. The values of the contact angle measurements indicated increased wettability for the HCP than the control...
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Posted by admin on Oct 31, 2020 in |
Background: Polycystic ovarian syndrome (PCOS) is a very common Endocrine Disorder encountered in women in which there is an imbalance of female sex hormones. It is associated with problems such as menstrual irregularities, Hirsutism, Obesity, Insulin resistance, acne, and in later life infertility with Diabetes mellitus and uterine cancer. Objectives: 1. Identify the subjects who are at risk for PCOS. 2. To make awareness about PCOS among young subjects. This will help to modify their lifestyle and to have better reproductive life later. 3. To improve the quality of life by reducing the risk of complications. Methodology: The study design was a prospective observational study carried out in Sangareddy (Telangana state) for a period of 6 months. A Survey of 805 subjects was done to assess the knowledge of polycystic ovarian syndrome. The data was collected from the subjects by using a structured questionnaire. Results: Results indicated that there is 26.9% in the age group of 16-20 years and 36.4% in the age group of 21-25 years and 31.2%...
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Posted by admin on Oct 31, 2020 in |
Rutin trihydrate a herbal drug having abundant medicinal properties, mainly used for topical treatment of inflammation, presents a hindrance and reduced anti-inflammatory activity. It is a BCS class II drug having low oral bioavailability, poor water solubility (0.125 g/L), and low stability of rutin in aqueous alkaline medium, restricting its application in use. So, it is successfully formulated as an emulgel to improve its anti-inflammatory properties. The current study aims to design, formulate, and to optimize Rutin trihydrate emulgel to enhance its efficacy and stability. Emulgel was designed, optimized by using central composite design taking three independent variables and one dependent variable. Five responses were generated, and the optimized formulation was prepared using carbopol 934(0.8%), clove oil (12.5 ml), and span (2.32%). The emulsifying agent being Tween 20, Span 20, and preservatives used are methyl and propyl parabens. The formulation (F2) with this combination gave emulgel of yellow color, homogeneous with good consistency, possessed pH of 6.51 ± 0.04, drug content of 98.7%, a viscosity of 14, 980 cps,...
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Posted by admin on Oct 31, 2020 in |
Miconazole nitrate is a broad-spectrum antifungal agent, and it is used for the treatment of superficial fungal infections. It has low skin permeability. Therefore, the aim of this study was to prepare proniosomal 2% miconazole nitrate sustained release to a treat deep-seated fungal infections. The different batches of proniosomal 2% miconazole nitrate gel were prepared by the conservation phase separation method using different non-ionic surfactants and Cholesterol. Preliminary trial batches were formulated and evaluated for different evaluation parameters like pH, viscosity, % entrapment efficiency, % drug content, and in-vitro drug release study. A 32 full factorial design was used to check the effect of Span 60 (X1) and Cholesterol (X1) on % entrapment efficiency (EE) and % drug release at 20 h (Q20). Multiple linear regression analysis, ANOVA, and graphical representation of the influence factor by 3D response surface plots were performed using Design Expert 9. Checkpoint batch was prepared to validate the evolved model. Optimized batch was found to be stable, and it showed release 94.76% in 24...
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