Posted by admin on Nov 30, 2020 in |
The objectives of the present investigation were to formulate and evaluate of Medicated oral jelly containing Trazadone HCl for the treatment of depression. Many psychotic patients are medicinal phobic who are afraid of taking medicine, so this preparation is most beneficial over that type of fear. Trazadone HCl antidepressant drugs incorporate in jelly and give to those patients; in this way, we could administer medicine to them without bringing this to their attention. Jellies are prepared by heating and congealing methods by dispersing gelling agents in water and evaluated for their physicochemical parameters like appearance, stickiness, pH, viscosity, Spreadability, stability studies, drug release, and content uniformity. All batches (F1-F8) of medicated jelly showed acceptable and comparable appearance, pH, viscosity, Spreadability, stability studies, drug release, and content uniformity. The viscosity range was found to be 53305 to 61731cps. The drug content of F1 to F8 formulations was found to be in the range of 88.42 to 98.95%. F7 batch prepared with gelatin + xanthan gum combination shows 98.95%. drug...
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Posted by admin on Nov 30, 2020 in |
The aim of the present study was to investigate the effect of Curcumin on blood glucose levels, body weight changes, and oxidative stress markers in the diabetic rat liver. Diabetes exacerbates hepatic injury induced by hyperglycemia mediated oxidative stress. A marked decrease in the blood glucose levels, body weight changes and anti-oxidant marker enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and increase in malondialdehyde (MDA) was observed in the diabetic rats. Decreased activities of antioxidant enzymes and body weights in diabetic rats were augmented on the oral administration of Curcumin. Moreover, Curcumin administration depleted the MDA level, which was earlier increased in the diabetic rats. These results suggest that Curcumin exhibits a hepatoprotective effect by accelerating hepatic anti-oxidant defense mechanisms and downregulating the MDA levels to the normal levels in the diabetic rats. Thus, Curcumin may be used as a therapeutic agent in preventing complications in diabetic...
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Posted by admin on Nov 30, 2020 in |
During the present investigations attempt was made to the green synthesis of silver nanoparticles using root extract of Aerva tomentosa Forsk. and to analyze its antibacterial and antioxidant activities. Exposure of the root extract of Aerva tomentosa to aqueous AgNO3 resulted in the formation of silver nanoparticles. The synthesis of silver nanoparticles was confirmed by UV-Vis spectrophotometer and was characterized by X-ray diffractometer. The bactericidal activity of silver nanoparticles against Escherichia coli, Bacillus thuringiensis, Bacillus subtilis and Pseudomonas putida was determined using bacterial growth inhibition method. The antioxidant study of silver nanopartcles was analyzed by the 2, 2-diphenyl-1-picrylhydrazil (DPPH) radical scavenging method. The synthesis of AgNPs via this green approach by Aerva tomentosa root extract were average size particles and crystalline in nature. The synthesized silver nanoparticles with two concentrations (0.01g/100µl) and (0.005g/100µl) exhibited high antibacterial activity in terms of maximum zone of inhibition against Escherichia coli, Bacillus thuringiensis, Bacillus subtilis, and Pseudomonas putida. Silver nanoparticles also showed significant antioxidant activity. There was a dose-dependent increase in the percent antioxidant activity...
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Posted by admin on Nov 30, 2020 in |
Syzygium aqueum is a well-known edible fruit-bearing plant species. The tribal people in Malaysia used different parts of the plant to cure various ailments. The previous studies on phytochemical evaluation of S. aqueum are very limited. The present study aims to conduct a detailed investigation of phytochemicals present in the leaves of S. aqueum and also its potential use as an effective antioxidant agent. In this study, the methanolic leaf extract of S. aqueum was tested to determine its chemical composition and its antioxidant activity. The result of the preliminary phytochemical investigation in leaf extract of S. aqueum revealed the presence of several bioactive secondary metabolites such as phenolic compounds, flavonoids, tannins, steroids, and terpenoids. Quantification results showed that the total phenol was found to be 62.89±1.48% GAE and the flavonoid content was 15.05±0.36% QE. Further analysis of the antioxidant activity in leaf extract of S. aqueum using different antioxidant assays proved that the extract effectively scavenging diverse types of free radicals. In different antioxidant assays, the leaf extract...
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Posted by admin on Nov 30, 2020 in |
The medicinal herbs used by native people of Mexico since ancient times for numerous therapeutic purposes. The plant is inborn to Mexico but is now well familiarized throughout India on wastelands. In India Martynia annua L. is a well recognized small herbaceous annual plant. The present study was carried out with HPTLC, and the results showed that there were many photochemical in Martynia annua L. Pre-coated HPTLC graded plates and autosampler was used to achieve precision, sensitive, significant separation both qualitatively and quantitatively. From HPTLC studies, it has been found that Petroleum-ether, acetone, and methanol extracts contain a mixture of compounds. Therefore, it is established that the pharmacological activity shown by them was due to the cumulative effect of all the compounds in a composite. Total eleven compounds identified; the most prevailing compounds were, Oleic acid (30.61%), 2, 5-dihydroxybenzoic acid (36.3%), 1-Hexyl-2-nitrocyclohexane (31.01%), and Cynidin-3-galactoside (34.14%). Other components were Apigenin-7-A-D, glucoside (4.4%), Pelargonidin-3, 5-diglucoside (12.9%), Ethanol, 2-(2-aminoethoxy) – (16.78%), n-Hexadecanoic acid (17.13%), Eicosanoic acid (18.55%), Chlorogrnic acid (25.07%) and...
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