Posted by admin on Apr 30, 2020 in |
Cognitive functions are mainly categorized into memory, attention, creativity, and intelligence. Cognitive enhancement may be defined as the amplification or extension of core capacities of the mind. Phenylethylamine is an organic compound which is also known as β-phenylethylamine (β-PEA) and is the name of a class of chemicals which shows psychoactive and stimulant effects. It is a trace amine and a natural monoamine alkaloid. PEA plays an important role in weight loss, treating depression, ADHD and Alzheimer’s disease, etc. The main objective of this study is to synthesize derivatives of ethylamine and phenyl-ethylamine, which may inhibit MAO receptors and improve cognitive behavior. All synthesized derivatives were studied for their biological evaluation on the brain, and they showed the good neurological activity and found effective to reverse the memory deficits induced by scopolamine. While, there is no significant effect was seen in the locomotor effect, which represent that these agents are effective to control the motor...
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Posted by admin on Apr 30, 2020 in |
The validated protein precipitation method was applied for the estimation of Baloxavir marboxil in human plasma with Oseltamivir as an internal standard (ISTD) by using HPLC-ESI-MS/MS. The chromatographic separation was achieved with 0.1% formic acid in combination with methanol (25:75 v/v) using the C18 column Ascentis Express (50 mm × 4.6 mm, 2.7 µm). The total analysis time was 3 min and the flow rate was set to 0.6 ml/min. The mass transitions of Baloxavir marboxil and Oseltamivir obtained were m/z 572.6®250.3 and 313.2®269.1. The standard curve shows a correlation coefficient (r2) greater than 0.9983 with a range of 5.00-10000.00 pg/ml using the linear regression...
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Posted by admin on Apr 30, 2020 in |
A simple, rapid, accurate, robust, and specific HPLC method was developed for the assay of metformin hydrochloride and teneligliptin hydrobromide from the oral tablet formulations. Stability-indicating reverse-phase chromatographic method was developed on a RP C18 column (250 mm × 4.6 mm, 5µm) using a mixture of 20 mM ammonium acetate of pH 5.5 and methanol in the ratio 50:50 v/v as mobile phase in an isocratic mode of elution at a flow rate of 1.0 ml/min at 35 ºC with a load of 20 µl. The detection was carried out at 255 nm. The method was validated with respect to linearity, robustness, precision, accuracy, specificity & stability as per ICH guidelines. The method produced excellent separation with good linear correlation coefficients (≥ 0.999) for both the components. The proposed method could be successfully applied for the assay of metformin hydrochloride and teneligliptin hydrobromide from tablet...
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Posted by admin on Apr 30, 2020 in |
Costus pictus D. Don., commonly known as the ‘Insulin plant’ is being used as a natural remedy to treat diabetes mellitus. The present study is focused to identify the chemical constituent responsible for the anti-diabetic activity of Costus pictus. The methanol extract was prepared from the fresh leaves of Costus pictus and washed with water to remove excess oxalic acid content present to get the non-toxic water-insoluble extract (CWI). The CWI was fractionated into low polar (CWI-LP), medium polar (CWI-MP) and high polar (CWI-HP) fractions by silica gel column chromatography. CWI and CWI-HP fraction showed prominent dose-dependent glucose tolerance effects in rats by GTT whereas the other fractions did not show any effect. Phytochemical analysis of CWI-HP resulted in isolation and characterization of the active compound present, namely β-Sitosterol-3-O-β-D-glucoside (daucosterol). The compound was purified by silica gel column chromatography and identified using various spectroscopic techniques, mainly through 1D and 2D NMR, HRMS. Since daucosterol is unstable in acidic pH, the enteric coating was performed on the molecule and CWI-HP...
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Posted by admin on Apr 30, 2020 in |
Last few decades, the remarkable advancement in the drug delivery system has been done; the oral route remains the importance and picks up the safest route of drug delivery. Regardless of striking advancements in the oral route medication, the current study focused on the formulation of a linagliptin buccal adhesive tablet. Formulated tablets are containing linagliptin as an active drug with a combination of different polymers such as carbopol (CP), eudragit RL-100 (EU), sodium alginate (SA) at different compositions with an impermeable backing layer of ethyl cellulose (EC). The formulation was carried out by direct compression, and tablets were evaluated by different parameters for pre and post-compression study. The post-compression evaluation parameters are weight variation test, hardness, thickness, friability, drug content, swelling index, pH followed by in-vitro drug release studies at pH 6.8. Compatibility study between drug-polymerr interactions was investigated by FTIR studies. Formulation F6, which contains a high concentration of EU provides maximum prolong the release of linagliptin among all other formulations. Formulation F6 has shown better control...
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