Posted by admin on Mar 31, 2020 in |
Munronia pinnata is a rare medicinal plant, naturally distributed in China, India, Vietnam, Indonesia, Malaysia, Philippines, and Sri Lanka. The entire plant is extensively used for medicinal purposes, especially for curing skin diseases and treating fever, including malaria. Four major ecotypes were identified in Sri Lanka that consist of 3, 5, 7, and 9 leaflets from various regions. This study was performed to investigate the phytochemical activity of four different ecotypes of Munronia. Leaves of ecotypes were collected and dried at 45 ºC for 15 h. The methanol extracts were prepared and used for screening of antioxidant activity, total polyphenol content, antifungal, and anti-diabetic activity. The findings were indicated that all ecotypes attest to significant differences in its activity but to varying degrees. The strongest antioxidant activity, highest polyphenol content, and mild inhibitory activity for Cladosporium cladosporioides were observed in ecotype with 3 leaflets. Ecotype with 7 and 9 leaflets showed moderate activity, and ecotype with 5 leaflets was the lowest for all tested properties. None of the ecotypes...
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Posted by admin on Mar 31, 2020 in |
Objective: The bioactive compounds of Rhizopora mucornata were docked against the bacterial enzyme protein tyrosine phosphatase to determine the potential inhibition. In this research the molecular docking analysis of drug compounds with virulent protein was studied. Material and Methods: Protein Tyrosine phosphatase is an enzyme that is being present in staphylococcus infection that plays an important role in cellular localization, enzyme stability. The target enzyme for Staphylococcus aureus was studied and retrieved from PDB. The bioactive compounds from the leaf extract of Rhizopora mucornata was screened for Lipinski rule of Five and ADMET properties. Autodock 4.2.3 software was used for molecular docking, and the visualization was done by using discovery studio 3.1. Result: The compound 3-methyl-2-(2-oxopropyl) furan shows better binding energy with -1.14 Kcal/mol against the enzyme protein tyrosine phosphatase followed by 3-cyclopentylpropionic acid, 4-methoxyphenyl ester +35.14 Kcal/mol. The hydrogen interactions and Vander Waals interactions, along with total residues of amino acids were studied. This research mainly focuses on targeting the virulent enzyme by using potential drugs to discover...
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Posted by admin on Mar 31, 2020 in |
This was a 24-week, randomized, open label study. Treatment-naive patients diagnosed with Type 2 diabetes mellitus were randomized into two groups, Group-1 (Vildagliptin 50 mg, twice dailyplus Metformin 500 mg, twice daily) and Group-2 (Teneligliptin 20 mg, once dailyplus Metformin 500 mg, twice daily). The primary objective was to compare fasting plasma blood glucose levels (FBG), 2-h post prandial blood glucose levels (2-h PPG) and HbA1c reduction from baseline in both the groups at the week 24 endpoint. From comparable baseline values HbA1c decreased in both treatment groups, to the greater extent with teneligliptin plus metformin combination therapy. Reductions in FPG were superior with teneligliptin plus metformin combination therapy [change from baseline -38.63 mg/dL] (p>0.05). Reductions in 2-h PPG were also superior with teneligliptin plus metformin combination therapy [change from baseline -37.85 mg/dL] (p>0.05). There was no incidence of hypoglycemia with either combination therapy. Efficacy and Safety of Teneligliptin over a period of 24 weeks was comparable to that of vildagliptin when given with stable doses of...
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Posted by admin on Mar 31, 2020 in |
In present study, a successful attempt has been made to study the variation in electrochemical behavior of Furazolidone and Metronidazole simultaneously using Differential Pulse Voltammetry (DPV) technique. The effect of different pH (2-10) of Britton-Robinson Buffer on voltammogram using 1M KCl as a supporting electrolyte was studied. The optimum pH was found to be pH 4.25. Both Furazolidone and Metronidazole exhibited reduction cathodic peak at optimum pH with peak potential at -0.06 V for Furazolidone, and -0.22 V for Metronidazole vs. S.C.E. 0.1N CH3COOH was used as Solvent for the analysis. The variation in electrochemical behavior of Furazolidone and Metronidazole simultaneously at the optimized pH was studied by varying pulse amplitude and scan rate. The optimized pulse amplitude was found to be 50 mV, and the optimized scan rate was found to be 15 mV/s. This study can be used developing methods for simultaneous detection and quantification of Furazolidone and...
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Posted by admin on Mar 31, 2020 in |
This study evaluates the effectiveness of corticosteroid fluticasone propionate, antihistaminic azelastine, and a combination of both as well as to find out the prognostic significance of absolute eosinophil count (AEC) in the topical treatment of allergic rhinitis. All cases presenting with symptoms of nasal allergy were included maintaining double-blind status. A total of 225 participants of groups I, II and III were treated with topical azelastine, fluticasone propionate and combination of both. The individual symptom score was recorded before and after treatment at the end of four weeks with the help of symptom evaluation scale. The effectiveness of group-specific drugs was evaluated by comparing individual and total symptom scores. AEC was repeated at the end of four weeks in all cases. After intervention the reduction of total symptom score (TSS) and AEC was 9.26 ± 0.01, 11.73 ± 0.54, 11.08 ± 1.61 and 205.59 ± 81.18, 176.05 ± 38.23, 195.75 ± 29.22 in group I, II and III respectively. Similarly for sneezing it was 0.21±0.41, 0.24 ± 0.43 and...
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