Posted by admin on Jan 31, 2020 in |
Alangium salvifolium is a plant that is traditionally used to treat many diseases like laxative, antiepileptic, jaundice, antiulcer agent, agent to alleviate spasms, anthelmintic, emetic, antiprotozoal agent and hypoglycemic agent. Its subspecies Alangium salvifolium subsp. Hexapetalum (Wangerin) is also known for a variety of traditional use like hemorrhoids, rheumatism, and antidote for snake bite. The present work aims for the evaluation of the in-vitro and in-vivo anti-diabetic activity of methanolic extract of aerial parts of Alangium salvifolium subsp. Hexapetalum (Wangerin). The in-vitro antidiabetic activity was evaluated by a starch-iodine color assay method. The in-vivo method was performed by administering orally the methanolic extract of Alangium salvifolium subsp. Hexapetalum in streptozotocin-induced male Albino Wistar rats weighing 200 g. The study was compared using standard metformin hydrochloride (10 mg/kg body weight). The in-vitro method showed a dose-dependent anti-diabetic activity that is as the dose increases the percentage inhibition of enzyme activity also increases. The in-vivo anti-diabetic activity was accessed by comparing the body weight and blood glucose level on 0th, 5th, 10th...
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Posted by admin on Jan 31, 2020 in |
In this study attempt has been made to develop the monographic parameters for Ficus glomerata Rox. leaves were collected from Gangetic plains (Lucknow). Under the study, pharmacognostic parameters were performed including macroscopic characters, microscopic characters, physicochemical parameters (extractive values, ash values, pH analysis, LOD), and preliminary phytochemical screening. Apart from pharmacognostic and phytochemical screening, HPTLC fingerprinting profile was also developed for F. glomerata Rox. Leaf extract. Pharmacologically active secondary metabolites like polyphenols and flavonoids were determined by using methods of phenolic content assay and total flavonoid content assay respectively. Leaf powder of F. glomerata was subjected to successive extraction with petroleum ether, chloroform, methanol and water. Different extracts were utilized for different parameters as per the requirement of...
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Posted by admin on Jan 31, 2020 in |
Aegle marmelos commonly known as Bael has been widely used traditionally due to its various medicinal properties. Cyclophosphamide is an alkylating agent used in the treatment of various types of cancer by slowing or stopping the growth of cancer cells but also affecting the normal cells leading to immunosuppressant effect. The present study has been aimed to see the protective effect of hydroalcoholic extract of Aegle marmelos fruit (AME) in normal and immunosuppressed rats. Different doses of AME i.e. 100, 250 and 500 mg/kg were administered orally for 14 days. On 15th day cyclophosphamide was given at a dose of 180 mg/kg subcutaneously. On the 18th day, hematological parameters like red blood cells (RBC), white blood cells (WBC), platelets, and neutrophil adhesion assay were carried out. AME showed a significant increase in white blood cell count, neutrophil count, eosinophil count, lymphocytes count and Neutrophil adhesion assay in cyclophosphamide treated rats. The results indicate the potential protective effect of AME in cyclophosphamide induced bone marrow suppression in...
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Posted by admin on Jan 31, 2020 in |
Metabolites from natural sources (microbes, plants, animals) have helped to double the human life span during the 20th century, combated pain and suffering, and revolutionized the practice of medicine. Microbes have provided compounds that have cured or reduced the effect of human diseases for 70 years. Microbial products include antibiotics against bacteria and fungi, antitumor drugs, immunosuppressants, enzyme inhibitors including hypocholesterolemics, anti-parasitic agents, bioherbicides, plant growth regulators, biopesticides and bioinsecticides. Cyanobacteria produce many compounds with activities such as neurotoxic, anti-proliferative, anticancer and anti-infective. These are Gram-negative photoautotrophic prokaryotes carrying out oxygenic photosynthesis. They are known as blue-green bacteria due to their production of C-phycocyanin, a blue green pigment used for photosynthesis. Their products have anticancer, anti-bacterial, anti-viral, immunomodulatory and protease-inhibition activities. The present study was performed in order to isolate and screen the cyanobacterial cultures for the metabolites of nutraceutical importance. The results showed the isolation of cyanobacterial cultures viz. Anabena sp and Cylindrospermum sp. The 75% populations of dominant isolates were of Anabena sp while 25% population isolated...
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Posted by admin on Jan 31, 2020 in |
Novel metal complexes of ligands of pyrazoline derivatives were synthesized by the condensation of 1-acetyl-2-hydroxynapthalene and indole-3-carboxaldehyde followed by the condensation of substituted phenylhydrazine. They were characterized by elemental analysis, IR, 1H-NMR, UV-Vis., molar conductance, magnetic susceptibility measurements and electrochemical studies. Based on the magnetic moment and electronic spectral data, square planar geometry has been suggested for metal complexes. The binding behavior of the complexes with calf thymus DNA has been investigated by electronic absorption spectra and cyclic voltammetry techniques. The DNA binding constants reveal that all these complexes interact with DNA through intercalation binding mode. Superoxide dismutase and antioxidant activities of the copper complexes have also been studied. The antioxidant activities of the complexes showed higher activities. Fluorescent studies reveal that the absorption band is shifted towards visible region indicates that the pyrazoline derivatives of metal complexes may exhibit different emission with respect to suitable substituent present in the pyrazoline structural core. Naphthyl group is responsible for the green colour emission due to its conjugation and electronic delocalization...
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