Posted by admin on Mar 31, 2020 in |
The present study was carried out to evaluate the gastroprotective effect of melatonin, coenzyme Q10 (CoQ10) and its combinations with rabeprazole in aspirin (400 mg/kg) and ibuprofen (300 mg/kg) induced gastric ulcers in albino Wistar rats. In aspirin-induced gastric ulcer model, the treatment of melatonin (20 mg/kg), CoQ10 (100 mg/kg) and rabeprazole (20 mg/kg) for 10 days significantly reduced the ulcer index with the values of 1.333 ± 0.30, 1.250 ± 0.2 and 0.916 ± 0.18 respectively whereas the ulcer index of combination treatment of melatonin with rabeprazole and CoQ10 with rabeprazole for 10 days was found to 0.416 ± 0.12 and 0.250 ± 0.11 respectively compared with control wherein the ulcer index was 2.88 ± 0.16. In ibuprofen induced gastric ulcer model, the treatment of melatonin (20 mg/kg), CoQ10 (100 mg/kg) and rabeprazole (20 mg/kg) for 10 days significantly reduced the ulcer index with the values of 1.500 ± 0.21, 1.417 ± 0.15 and 0.833 ± 0.27 respectively whereas the ulcer index of combination treatment of melatonin with...
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Posted by admin on Mar 31, 2020 in |
Nutraceutical term is a combination of terms nutrient and pharmaceutical. There is a wide scope in applying pharmaceutical formulation parameters to nutraceuticals. Amongst the variety of nutraceuticals available, powder form of nutraceuticals are most popular. The nutraceutical powder mixtures can contain many ingredients, of which the nutrient source contents are generally present in more than 50% of whole formula. Optimization of the powder formulations for pharmaceutical and organoleptic parameters is the needed approach. Under this study optimization, evaluation, and stability study of nutraceutical powder formulations developed from edible seed and leafy vegetable sources is done. The research done involves development of two nutraceutical powder formulations one from edible seed sources namely – Cucumis melo, Punica granatum and Linum usitatissimum in 1:1:1 proportion, and second from green leafy vegetable sources namely Trigonella foenum graecum, Coriandrum sativum, Raphanus raphanistrum and Anethum graveolens in 1:1:1:1 proportion. The seeds and leafy vegetables selected were screened for macro and micronutrient content, prebiotic and antioxidant potential. Its in-vivo effect is measured as blood parameters and...
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Posted by admin on Mar 31, 2020 in |
Complementary and alternative medicines (CAMs), particularly herbal medicines (HMs), are popular with diabetic patients and are often used alongside conventional treatments. In such cases, patients usually do not advise their doctor or any other healthcare professional, so inappropriate use and potential interactions between CAM therapies and conventional treatments are serious concerns. This study attempted to identify the main factors affecting CAM decision-making by studying the association between CAM use and patient characteristics, including age, gender, diagnosis, reasons for using, time of starting, and sources of HM products. It was aimed to shed light on patients’ experiences and perceptions of CAM use, particularly HMs, to identify any perceived benefit or harm. Cross-sectional questionnaire surveys, including open-ended and closed-ended questions, which were administered to eligible participants. The results revealed that approximately 34% of the 98 patients participating in the study used CAM. The most prevalent age group of participants was 51-60 years old (39.8%). The most used HMs were the olive leaf (21.2%), green tea (21.2%), cinnamon (21.2%), black seeds (15.2%),...
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Posted by admin on Mar 31, 2020 in |
The objective of the present study was characterization, production, and purification of Nattokinase from Bacillus subtilis. A fibrinolytic enzyme-producing bacterium was isolated and identified as Bacillus subtilis from fermented soybean and soil. Bacillus subtilis showed a very strong protease activity by degrading casein skimmed milk agar. Nattokinase was produced on basal medium and then purified from supernatant. The crude enzyme was purified by ammonium sulphate precipitation, followed by dialysis and DEAE cellulose ion-exchange chromatography. Total protein was estimated by Lowry’s method (0.58 mg/ml for FS2 and 0.49 mg/ml for S1) and enzyme-specific activity was determined by tyrosine standard (0.52 µmole/mg/ml for S1 and 0.59 µmole/mg/ml for FS2). The molecular weight of purified enzyme was determined by SDS-PAGE (20-24 kDa for FS2 and 41-44 kDa for S1). Finally, the fibrinolytic activity was determined by application of extracted enzyme on pre-existing human blood clots (FS2 showed greater activity compared to...
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Posted by admin on Mar 31, 2020 in |
Environment provides a solid platform for good health. An unhealthy environment makes place unsafe for wild animals. One of the effects is a parasitic load on these animals, as a high degree of parasitization may cause harm to the health of these animals. In the present research work, blood parasitic infestation in two species of lizards, Hemidactylus flaviviridis and Calotes versicolor were investigated and it was observed that lizards from the highly polluted area were infested with high parasite load that ultimately caused harm to these animals which biologically constitute an important part of the food chain. The intensity of blood parasites (Hepatozoan and Plasmodium) in lizards from different habitats was studied and it was observed that highly polluted areas (Mirzapur) had a high incidence of the parasites. It is known that Mirzapur is more polluted than Bareilly and Chandausi, the other sites selected for investigation. Parasites are regarded as indicators of pollution. To make the environment healthy and peaceful, positive energy and healthy habitats can contribute to a...
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