Posted by admin on Sep 30, 2019 in |
The solar UV radiation is the major trigger factor that causes skin cancer. Nearly 65% of cases of melanoma occurs dues to high exposure to the UV radiation. It also accounts for 90% of the nonmelanoma skin cancers also referred to as NMSC also including the cases of basal cell carcinoma (BCC) and the squamous cell carcinoma (SCC). The rate of malignancy in other cases has seemed to get reduced but this is not the situation in case of NMSC, which seemed to have increased and also affect people of younger ages. Cases of NMSC can be accounted for 15,000 deaths in the USA alone. This is surely one of the major health concerns of the nation also. In order to find a solution to this problem a new form of drug delivery system using the specific ligand that has receptor on the surface or the target cells is being proposed. The current discussion deals with the making of the mannosylated quercetin loaded liposomes that can be used for...
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Posted by admin on Sep 30, 2019 in |
The present study was designed to determine the role of Andrographis paniculata (AP; 50 mg/kg) against the oxidative stress caused by the arsenic (0.5 and 1.0 mg/kg) for 30 days in adult mice. The results of in-vivo studies demonstrated that arsenic treatment resulted in a significant dose-dependent increase in the ovarian arsenic level and lipid peroxidation (LPO), followed by a marked reduction in gravimetric data, levels of total ascorbic acid, glutathione and in the activities of superoxide dismutase, catalase, and glutathione peroxidase. A significant reduction in the activities of 3b and 17b hydroxysteroid dehydrogenases along with elevated levels of cholesterol indicated ovarian endocrine dysfunction. These results suggest that an increase in free radical formation relative to loss of antioxidant defense system during arsenic exposure may render ovary more susceptible to oxidative damage leading to their functional inactivation. On the other hand, co-administration of arsenic with Andrographis paniculata (AP) restored altered biochemical variables, antioxidant balance, and gravimetry which suggests that the free radical-mediated damage during arsenic-induced oxidative stress could have...
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Posted by admin on Sep 30, 2019 in |
Epilepsy is a disorder of the central nervous system. A seizure occurs when the brain’s nerve cells misfire and generate a sudden uncontrolled surge of electrical activity in the brain. Seizures can be controlled with modern medicines and surgical techniques and are found to have so many side effects. Natural products from folk remedies are an alternative source of anti-epileptic drugs with better safety and efficacy profiles. Rubiadin is an anthraquinone glycoside isolated from roots of Rubia cordifoia (Manjishta) known for a number of pharmacological activities. The present study was aimed to assess the anti-epileptic activity of isolated rubiadin from Rubia cordifolia. The evaluation of anti-epileptic activity was carried out with maximal electric shock (MES) and Pentylene Tetrazole (PTZ) models. Epileptic seizure were induced in mice of either sex and the challenged animals treated with Whole Rubia cordifolia root extract & isolated Rubiadin suspension at two doses 100 mg & 500 mg respectively. The isolated Rubiadin suspension at 500 mg dose showed significant reduction in MES and PTZ induced...
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Posted by admin on Sep 30, 2019 in |
Inflammation is part of the body’s immune response. There can be four primary indicators of inflammation: pain, redness, heat or warmness and swelling. Plants have the ability to synthesize a wide verity of phytochemical compounds as secondary metabolites which shows anti-inflammatory activity. The anti-inflammatory activity of ethanol extract of Tiliacora acuminata stem and leaf was evaluated using the carrageenan-induced rat paw edema. The ethanol extract of stem and leaf of Tiliacora acuminata was injected at different doses such as 200 and 400 µg/kg body weights, and the study was compared with standard drug indomethacin (10 mg/ml). In rat paw edema model induced by carageenan the extracts were found to reduce similarly (p<0.001). The formation of edema at the 400 µg/ml dose level and showed 77.92% for stem and 84.37% for leaf respectively, inhibition of edema volume at the end of 3 h. These results suggest that Tiliacora acuminata has anti-inflammatory property comparable with those of standard drug and may be useful for the treatment of painful inflammatory...
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Posted by admin on Sep 30, 2019 in |
The present study investigates the wound healing activity of ethanolic extract of the fruit of Luffa acutangula. The medicinal values of the Luffa acutangula have been mentioned ancient literature as useful in disorders of wound. Dried fruits of Luffa acutangula were powdered and extracted with ethanol using soxhlation method. Ethanolic extract of Luffa acutangula was evaluated for its wound healing activity in rats using excision wound model with help of Plethysmometer. Soframycin used as a standard drug. For this activity test groups received ethanolic fruit extract of Luffa acutangula. Results showed that in excision wound healing model, animals of standard treated and drug-treated (treated with ethanolic extract of Luffa acutangula) groups showed significant decrease in wound contraction ability, epithelialization period when compared to animals of normal...
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