Posted by admin on Apr 30, 2019 in |
The assessment of the probability of occurrence of deep vein thrombosis played a very important part in making a correct diagnosis and modified Wells’ score is a widely used prediction rule for pre-test probability assessment. We aimed to evaluate the diagnostic accuracy of the modified Wells’ score in the diagnosis of lower extremity deep vein thrombosis compared to Doppler ultrasound study. This is a cross-sectional study conducted in Baghdad Teaching Hospital from Jan 2017 till Dec 2017. Adults inpatients suspected of having lower-extremity deep vein thrombosis were included after taking verbal consents. Patients on antithrombotic treatment and those suspected to have pulmonary embolism were excluded. According to Wells’ score; patients were divided into likely and unlikely groups. Lower extremity venous duplex ultrasound study was established. Correlation of Wells’ score with DVT and its efficacy was analyzed using receiver operating characteristic curve. A total number of 113 patients were included; with a mean age of 40.6 ±, 12.7 years and males were 60 (53.1%). Based upon Wells’ score, 45 (39.8%)...
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Posted by admin on Apr 30, 2019 in |
A series of new quinoline/chalcone hybrids 3a-e and 4a-e were designed and synthesized. The structures of all new target molecules 3a-e and 4a-e have been confirmed by various spectral techniques and elemental analyses. The newly synthesized compounds were screened for their antibacterial activity using agar disc diffusion method. Results showed that most of the newly synthesized compounds showed good antibacterial activity comparable with that of the standard drug Gatifloxacin against all tested strains (B. cereus, E. coli, and S. marcescens) except for P. aeroginosa where it does not respond to most of the newly synthesized compounds, and that compounds 3c, 4c, 4d, and 4e showed good antibacterial activity (53-78% that of Gatifloxacin) towards some bacterial strains (Bacillus cereus, Escherichia coli, and Serratia marcescens) when compared to standard drug Gatifloxacin. Amongst all the tested compounds, 4e exhibited excellent activity against S. marcescens (88% that of...
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Posted by admin on Apr 30, 2019 in |
The objective of the study was to formulate coated liposomes containing Prednisolone for colon targeting and localization of the therapy to the inflamed colon mucosa. Liposomes were prepared using thin film hydration method. Liposomal formulations were optimized using 32 factorial design using varying concentrations of SPC and cholesterol as independent variables and % EE as the dependent variable. Optimized formulation F5 (60:30) was selected for successive coating with chitosan and eudragit S-100. Chitosan concentration of 1% w/v was taken as optimal based on ZP values. The coated liposomes were encapsulated in eudragit S-100 shell using a solvent-free method. The size if liposomes increased upon addition of the coatings. Fluorescent microscopy aided in clear visualization of chitosan coating around the vesicles. SEM images showed a transition surface appearance in the order smooth-rough-smooth for F5 and the coated liposomes. Eudragit S-100 coated liposomes were subjected to in-vitro drug release studies using simulated fluids for 16 h. ECL5 with 2% w/v eudragit showed sufficient lag time of 6 h. The formulation was...
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Posted by admin on Apr 30, 2019 in |
An unusual type of the long-lasting pyelonephritis demonstrating a long-lasting granulomatous disease resulting in a non-functional kidney in the patient is generally linked with xanthogranulomatous pyelonephritis. The name itself suggests this involves a granulomatous progression that is chronic, due to a chronic or sub-acute infection in the patient inciting a chronic but incomplete immune reaction in the individual. Different bacteria are generally known to be identified, but the most commonly associated species are Escherichia coli and Proteus mirabilis. Clinical presentation of the patient suffering from the disease is typically unclear, consisting of symptoms like malaise, loss of weight and low-grade fever and loss of appetite. Blood in the urine (hematuria) and flank pain are generally presented in the patients with the disease. Urinary tract symptoms may not be present always, but pus in the urine and positive urinary cultures are present in many of the cases of the patients (95 and 60% respectively). The disease finally results in the replacement of the kidney by a mass of reactive tissue,...
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Posted by admin on Apr 30, 2019 in |
The synergistic activity among the monoterpene (S)-cis-Verbenol and the antibiotics Amoxicillin and Gentamicin were evaluated against a sensitive and a resistant strain of Staphylococcus aureus, is the last one also resistant to methicillin (MRSA). The combinations were evaluated by the checkerboard method. The combinations of both antibiotics with the terpene showed synergic effects for the MRSA strain, whereas for the sensitive strain one combination showed synergy with amoxicillin and additionally one combination showed the additive effect with Gentamicin. To confirm the observed results, the combination that had the lowest concentration of Amoxicillin and the monoterpene were assayed by the time-kill curve method. An even lower concentration of the terpene that did not show cytotoxicity against human cells was also assayed. The results obtained confirmed those of the checkerboard method and synergy was also observed for the non-cytotoxic concentration of (S)-cis-Verbenol analyzed. This opens interesting possibilities about the use of purely natural products in combination with antibiotics to treat infections produced by sensitive and resistant...
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