Posted by admin on May 31, 2019 in |
Objective: Oxidative stress and generation of free radicals leads to several chronic inflammatory diseases like arthritis, diabetes mellitus, cancer, etc. Arthritis is an immune-mediated systemic disorder known to impair the quality of life. In spite of development of drug discovery, therapeutic targeting of arthritis is still not satisfactory. Bellamya bengalensis has been long known for used in ailments like arthritis, asthma, conjunctivitis in traditional medicine. There are very few studies for clarification of scientific understanding of these therapies. In the present study, a purified fraction of Bellamya bengalensis mass (PBB) was assessed for oxidative stress in arthritis in Wistar rats. Methods: Arthritis was induced by 0.1 ml of Freund’s complete adjuvant (FCA) in the left hind paw of Wistar rats. After that, PBB was administered orally at 100 mg/kg, 200 mg/kg and 400 mg/kg doses for consecutive 28 days. A thorough investigation of serum and tissue parameters, including autopsied histopathological analysis, related to systemic dysfunction due to oxidative stress during arthritis were evaluated at the end of the study....
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Posted by admin on May 31, 2019 in |
The aim of the present study was to investigate antioxidant activity, total polyphenols and total flavonoids contents of extracts from two Moroccan Teucrium species (Teucrium polium and Teucrium aurum). The Antioxidant activity was evaluated in-vitro by three assays namely, free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and total antioxidant capacity. Total polyphenol content was measured using Folin-Ciocalteu assay. The aluminum chloride colorimetric test measured total flavonoids contents. The total phenols contents, flavonoids contents, and the antioxidant activity of T. polium extracts were higher than T. aurum. The phenols contents ranged from 109.28 to 20.61 mg GA E/ g dry extract. The total flavonoids varied between 102.99 and 10.33 mg RE/g dry weight. The extracts showed significant scavenging activity of DPPH, with IC50 values ranging between 0.40 and 2.12 mg/ml and a good ferric reducing power, with IC50 values varying from 0.15 to 4.23 mg/ml. The total antioxidant capacity assay showed that the water extract of T. polium had a highest activity with a value...
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Posted by admin on May 31, 2019 in |
Two species of Riccia, namely Riccia billardieri and Riccia discolor, were studied to detect various amino acids qualitatively as well as quantitatively through HPLC. Seven amino acids (histidine, serine, tryptophan, asparagine, tyrosine, valine, and isoleucine) were observed to be common in both the species but varying significantly in their quantities. Riccia billardieri contained additionally four (lysine, glycine, cystine, and proline) amino acids and Riccia discolor one (glutamine) amino acid. The contents of histidine (0.597 mg g-1dw) and asparagine (0.323 mg g-1dw) were found higher in Riccia billardieri, but the concentrations of tryptophan (0.927 mg g-1dw), serine (0.169 mg g-1dw), tyrosine (0.024 mg g-1dw), valine (0.394 mg g-1dw) and isoleucine (1.770 mg g-1dw) were higher in Riccia discolor. The value of asparagine was almost similar in both the species. In Riccia billardieri the concentration of histidine (0.597 mg g-1dw) was observed maximum, whereas in Riccia discolor isoleucine (1.770 mg g-1dw) was found in the highest amount. The presence of amino acids indicates the potential use of Riccia in the pharmaceutical...
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Posted by admin on May 31, 2019 in |
Clopidogrel, a poorly water-soluble drug, has been the mainstay of platelet management in acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI) for over a decade. Since Clopidogrel is a prodrug and requires hepatic metabolism for activation, it exhibits a slower onset of action upon oral administration. This time-lag before the onset on the action is highly undesirable for the treatment of critical conditions such as coronary intervention, which is a medical emergency during which the rapid onset of antiplatelet action is of paramount importance. To achieve rapid onset, intravenous is the preferred route of administration; however, due to poor aqueous solubility, development of the IV formulation of Clopidogrel presents a considerable challenge. In the present investigation, the liposomal formulation of Clopidogrel was developed, which enables IV administration and may potentially provide a rapid onset of action. The formulation was prepared and optimized using 32 full factorial designs with Design Expert 11 software and evaluated for critical quality attributes (% entrapment, particle size, PDI, zeta potential and Morphology, pH/dilution...
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Posted by admin on May 31, 2019 in |
Abelmoschus esculentus is one of the oldest urbane crops grown in many countries and widely distributed. Parts used of okra are fruit, leave seed, root wish showed to have numerous Medicinal significant uses. On the other hand, cigarette, smokers found to have a high a significant effect on liver kidney and other numerous organs in the body. Aim: The study aims to explore the possible protective effects of three parts of okra against nicotine-induced damage in many parts of the mice body. Methods: Fifty male Swiss albino mice were used throughout the study. After tow-weeks acclimatization period, the mice divided into 5 groups from the control group, nicotine-treated group, nicotine-okra pods extract -treated group, nicotine-okra skin extract treated group, and nicotine-okra seeds extract -treated group. Result: shown significant protective effects against nicotine damage effects as cholesterol level decrease in okra skin treatment with a significant difference in comparison with the positive group also okra protective effects on renal function have found that urea and creatinine levels decrease significantly in...
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