Posted by admin on Mar 31, 2019 in |
The present research focuses on the screening of phytochemicals from an Indian medicinal plant Diospyros melanoxylon Roxb. by both qualitative and quantitatively and biological activities. Different solvent extracts were prepared and used for this study such as hexane, chloroform, methanol, ethyl acetate and aqueous. Preliminary screening of phytochemicals revealed that the methanolic extract comprises alkaloids, carbohydrates, flavonoids, glycosides, phenols, saponins, tannins, terpenoids and triterpenoids than the other extracts. Further, in-vitro antibacterial activity was studied by well diffusion method using four different human pathogens viz. Acinetobacter baumannii, Escherichia coli, Salmonella typhi, and Staphylococcus aureus. Followed by, 3 different in-vitro antioxidant activities were performed in 5 different plant extracts. The antioxidant study revealed that the methanolic extract showed significant antioxidant activity than the others which indicate that methanol extract played an essential role in biological activities. Thus, Diospyros melanoxylon could be effectively employed as an ingredient in health or functional food to alleviate oxidative stress and related health...
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Posted by admin on Mar 31, 2019 in |
Objective: The objective of the current investigation is to study the combined influence of sodium alginate, uriddall mucilage and calcium chloride on drug encapsulation efficiency and particle size of microspheres. Zidovudine-loaded sodium alginate based uriddall mucilage microspheres were prepared by the solvent evaporation method. Further, optimization of the formulation was done using a three-factor, three levels of Box-Behnken design (BBD). Microspheres were subjected to surface morphology and in-vitro dissolution studies. Sodium alginate alone or in combination with uriddall mucilage and calcium chloride has a substantial influence on encapsulation efficiency and particle size of microspheres. Optimized formulation was obtained using desirability approach of numerical optimization. The experimental values of drug encapsulation efficiency and particle size for the optimized formulation were found to be 83.12 ± 1.38%, and 846.56 ± 2.56 μm respectively, which were in close agreement with those predicted by the mathematical models. The drug release was also found to be slow and extended for more than 12 h, and release rates were fitted to the Power law equation...
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Posted by admin on Mar 31, 2019 in |
After an increasing concern of sub-therapeutic use of antibiotics in poultry to treat enteric and other infections, an interest in alternative and efficient products with antibacterial properties has increased. From ancient time, the plants are constantly contributing as a useful source for the therapeutic and pharmaceutically important compounds. In this study, we therefore tested for the presence of important phytochemicals and antibacterial potential of Curcuma longa and Curcuma aromatica rhizome extracts against poultry enteric pathogens. Pharmaceutically important phytochemicals including alkaloids, flavonoids, terpenoids, steroids, saponins, phenols, glucosides, etc. were found to be present in extracts of C. longa and C. aromatica. The extracts of C. aromatica exhibited excellent inhibitory action against Escherichia coli and Salmonella entertidis. However, C. longa extracts showed zone of inhibition against E. coli alone. This study provides significant insight into therapeutic application of Curcuma spp. against enteric poultry pathogens, suggesting it’s potential as an alternative to antibiotics and opens the way for further use in poultry feed for effective...
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Posted by admin on Mar 31, 2019 in |
The objective of the present investigation was to develop a sustained release (SR) tablets of Doxazosin Mesylate by wet granulation technique using a combination of synthetic polymers (Eudragit RS-100 and Eudragit RL-100). Different batches of Doxazosin Mesylate sustained release tablets were prepared by using microcrystalline cellulose as diluents by wet granulation technique. The compatibility of the drug and excipients was ruled out by FT-IR studies and found to be compatible. Granules of prepared batches were evaluated for their physical properties and found to be good and satisfactory. Tablets were evaluated for various physicochemical parameters like hardness, thickness, friability, weight variation test, drug content, and in-vitro drug release. To study the effect of concentration of polymers on drug release from SR tablets, 32 full factorial design was applied. The concentration of Eudragit RS-100 and Eudragit RL-100 were used as independent variables, while percentage drug release at 2 h and 22 h were selected as the dependent variable. Contour as well as response surface plots were constructed to show the effect...
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Posted by admin on Mar 31, 2019 in |
The aim of this study was to (1) analyze the effect of fresh goat’s milk intervention on serum Carboxyterminal Cross-Linked Telopeptide of type I Collagen (CTX) and calcium in untrained healthy women, therefore goat milk can be used for osteoporosis therapy, (2) examined the relationship between levels of calcium and CTX after the intervention of fresh goat’s milk. The research design was a controlled randomized trial. Eighteen volunteers sedentary women were randomized into 2 equal groups (control, n=9, and trial, n=9), aged 18-19 years, healthy, and did not consume high calcium foods or drugs. The treatment group was treated with 250 ml/day of fresh goat’s milk, given in the morning, for 110 days. Fasting morning serum calcium and CTX levels were measured before and after fresh goat milk intervention. The data were analyzed by the statistical t-test and linear correlation with the significance level of 5%. Untreated, both serum calcium and CTX levels in the trial and control group were not significantly different (p>0.05). Treated, serum calcium levels were...
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