Posted by admin on Jan 31, 2019 in |
In response to the spacious propagation of bacterial contamination stimulated by pathogens, the evolution of novel therapeutics with eminent antibacterial action is of avid concern. When the skin unity is ruptured accidentally or intentionally, its natural defenses will thus be vitiated, and topical medication may be prescribed. Topical medicaments are designed to either obliterate or inhibit the augmentation of pathogenic microorganism and can be consumed for both prophylaxes as well as treatment of superficial infection. Here is a novelize graphene-usnic acid conjugate was developed by way of a mere non-covalent process, and the loading and release demeanor of usnic acid on graphene were investigated. An effective loading of usnic acid on graphene prevailed at the initial usnic acid assiduousness of 300 mg/ml. The developed conjugate was embedded into biocompatible Eudragit polymers to formulate topically active microspheres. Formulated microspheres were characterized by FTIR, TGA, and graphene. Antibacterial activity was studied by the broth dilution method. Results disclosed that amalgamation of graphene and usnic acid had enhanced antibacterial activity against pathogen...
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Posted by admin on Jan 31, 2019 in |
Free radicals and reactive oxygen species (ROS) production above basal levels cause irreversible damage to the cell membrane, DNA and other cellular structures by oxidizing lipids, proteins and nucleic acids resulting in dysfunction of biomolecules within cells and, finally, cell death. These free radical-induced reactions are ascertained to play multiple roles in degenerative or pathological events especially carcinogenesis. Apart from the radical scavenging activity, the antioxidant potential of a test compound or herbal preparation is also based on their protective effect against oxidant-induced damage to cellular biomolecules. In the present study, the protective effect of the methanolic extract of the three different flowers of Caesalpinia pulcherrima (yellow, pink and orange) against oxidative stress-induced damage to biomolecules like lipids, DNA and proteins were analyzed in both cell-free systems and intact cells. The results showed that the flowers of C. pulcherrima rendered significant biomolecular protection against oxidative stress, both in cell-free systems and in intact cells....
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Posted by admin on Jan 31, 2019 in |
Herbal drugs are prescribed widely as an anti-coccidial agent even when their biologically active compounds are unknown, because of their effectiveness, lesser side effects, and relatively low cost. So, in the current study, a poly-herbal formulation was used to find out its effect as an anti-coccidial effect. In the present study, the parameters evaluated were the WBC count, Glutathione levels, malondialdehyde (MDA) levels, and the in-vitro nitric oxide radical scavenging activity. All the altered parameters significantly brought back to normal by the administration of the polyherbal formulation in comparison to the standard drug Co-trimoxazole (20 mg/kg p.o.)The histopathology of the jejunum further revealed the healing effects of the polyherbal formulation in Eimeria papillata induced...
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Posted by admin on Jan 31, 2019 in |
Zinc deficiency is prevalent worldwide. The present study deals with the effect of dietary zinc deficiency on erythrocytes of Wistar rats. Male Wistar rats (40-50 g) were divided into 3 groups: control (ZC) fed 100 μg/g zinc; pair fed (PF) fed 100 μg/g zinc but the diet given was based on the diet consumed the previous day and zinc deficient (ZD) fed 1 μg/g zinc. The experiment was carried out for 2, 4 and 6 weeks. Erythrocyte cell suspension revealed significant increase in catalase activity and decrease in glutathione concentration after zinc deficiency. A significant (P<0.05) increase in erythrocyte lysate superoxide dismutase, glutathione peroxidase and glutathione-s-transferase was observed while glutathione reductase decreased significantly after zinc deficiency. The decreased glutathione reductase coordinates with decreased glutathione concentration making erythrocytes prone to oxidative stress while increased superoxide dismutase, catalase, glutathione peroxidase and glutathione-s-transferase reflects generation of excess free radicals not only due to auto-oxidation of haemoglobin but also due to loss of osmotic fragility leading to oxidative stress indicative of perturbation of...
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Posted by admin on Jan 31, 2019 in |
Rosella (Hibiscus sabdariffa L.) calyx traditionally used to treat various diseases. There is limited evidence based could be found including the efficacy and safety. The present study was aimed to investigate the effects of subchronic administration of Rosella calyx extract on the renal function of female Sprague Dawley (SD) rats. The rosella calyx was extracted by 70% ethanol and evaporated with a rotary evaporator to get concentrated extract. The Sprague Dawley rats were randomly divided into five groups including control group which was given CMC Na 0.5% and treated groups were administered orally with the extract of 50, 100, 200 mg/kg bw for 35 days. The satellite group was conducted for observing the reversibility, the observation in this group was conducted 14 days after 35 days of treatment. The biochemical function including ureum and creatinine was analyzed from a blood sample using enzymatic UV-test, and creatinine level were observed by the Jaffe method. The histopathology profile of kidney was observed with Hematoxylin and Eosin staining and followed by microscopic...
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