Posted by admin on May 31, 2018 in |
Hyperlipidaemia is mentioned as one of the life-style-related diseases as much as so for diabetes. In the present study an attempt was made to develop herbal capsules, which are containing the extract of Murraya koenigii and Achyranthus aspera. One of the major concerns in designing new formulation is that the active ingredient should be compatible with all the excipients and packaging material components. Incompatibilities will affect the efficiency of the drug. Thermoanalytical techniques were effectively employed for the preformulations studies. The results obtained by the thermoanalytical techniques showed no chemical incompatibility between hard gelatin capsule shell and extract. The results were further confirmed by IR spectroscopy. The herbal capsule was stored at different temperatures viz., 25 °C, 40 °C and 50 °C for shelf life evaluation. The organoleptic properties of the herbal capsule remains unchanged at tested temperatures throughout the stability study. The shelf life of the herbal capsule was found to be 6.4 years. The Harborne’s Quantitative Alkaloid determination method proved to be selective, precise, linear, sensitive, and...
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Posted by admin on May 31, 2018 in |
Natural biodegradable chitosan-sodium alginate polymer combination is a promising candidate for preparing drug-loaded implants because of the availability and inexpensiveness of the polymers over the semi synthetic biodegradable ones. The main objective of this research was to prepare and evaluate a biodegradable implantable system of the drug metoprolol tartrate because it plays an important role in the treatment of high blood pressure, strokes, heart attacks and angina. 70:30 and 80:20 chitosan – sodium alginate combination implants of metoprolol tartrate with 15 and 30 minutes exposure time to glutaraldehyde for hardening were prepared. It was observed that loading efficiency and drug release could be influenced by varying polymer ratios, exposure times to glutaraldehyde and excipients. The implant formulated with 25 mg drug load in 70:30 chitosan – sodium alginate ratio with 15 minutes exposure produced the maximum sustained release for 15 days. Therefore, this formulation was chosen for preparing implants containing different excipients and the implants were evaluated for loading efficiency and in-vitro drug release. Morphological characteristics of the implants...
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Posted by admin on May 31, 2018 in |
Efferevescent granules are granular dosage form of drug in a dry mixture usually composed of effervescents like sodium bicarbonate, citric acid and tartaric acid. Effervescent granules when added to water, the acids and the base react to liberate CO2, resulting in effervescence. A combination of tartaric acid and citric acid is used as an effervescent base rather than either acid alone because when tartaric acid is used alone, chalky friable granules are produced and citric acid alone results in sticky mixture to difficult to granulate. The weakly acidic drugs when formulated in effervescent granular forms exhibit increased absorption from gastric environment as most of the drug remains in unionized form. The bitter taste of the drug can be masked by the effervescence that was produced when the formulation is mixed with water. Effervescent granules of weakly acidic drug, metronidazole were formulated by melt granulation process in which low melting binder composition comprising of a polymer and a hydrophobic meltable binder like PEG 4000 and cetyl alcohol is used. Formulations...
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Posted by admin on May 31, 2018 in |
Cephalosporins are drug of choice for many infectious microorganisms even against many antibiotic resistant cases. Ceftriaxone, a third generation cephalosporin is effective in many infections including fluoro-quinolone resistant strains of Salmonella typhi, the causative pathogen for enteric fever (typhoid). The antibiotic is supposed to act in the intestinal cells but gastric instability limits the oral use of ceftriaxone. Present research aims to develop an orally bioavailable formulation of ceftriaxone which is otherwise available as parenteral owing to its gastric instability. Natural polysaccharides have been used as excipients and drug delivery carriers since long but are not good for linking to form prodrugs. Hydrolysis resistant fraction of Almond gum, whose structure has been elucidated as a trisaccharide is used to synthesize the prodrugs of ceftriaxone. Two peptide linkers i.e., glycine and phenylalanine have been used to link the trisaccharide with the cephalosporin in three steps. Both the prodrugs were characterized and evaluated in-vitro. IR and NMR data confirmed the synthesis of polymeric prodrugs and in-vitro evaluation shows sustained drug delivery...
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Posted by admin on May 31, 2018 in |
The present investigation was undertaken to determine the requisite pharmacognostic standards for evaluating the plant material. The macroscopic, microscopic, powder study, physicochemical, qualitative phytochemical and florescence analysis of the seed were carried out. The microscopic study showed abundant large parenchymatous cells with aleurone grains, calcium oxalate crystals, lignified trichomes, endocarp and testa throughout the section. The powder microscopy showed the presence of lignified trichomes, rossete crystals of calcium oxalates, oil granules, etc. The physicochemical properties such as total ash, water soluble ash, acid insoluble ash and sulphated ash were 5.75%, 5.16%, 0.16% and 6.66% respectively. The aqueous soluble and ethyl acetate soluble extractive values were 34.07% and 16.66% respectively. The qualitative phytochemical analysis showed the presence of maximum amount of flavonoids followed by triterpenes, steroids and alkaloids respectively. The seed powder showed characteristic flourescence with various chemical reagents. The data generated in the present work could be used as reference for the standardization and quality control of A. marmelos seed. It will help in identifying and preventing intentional or...
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