Posted by admin on Dec 31, 2017 in |
Rheumatoid Arthritis (RA) is a auto-immune disease in which body mistakenly considers some parts of its own system as pathogens and attacks them. RA is a chronic systemic inflammatory illness with prevalence of approximately 0.75% in India. It leads to irreversible joint damage and systemic complications. It is associated with substantial morbidity and increased mortality Better understanding of its pathophysiology has led to the progress of besieged therapies that have significantly enhanced outcomes. The key to beneficial achievement lies in identifying those who will have rigorous critical disease as early as possible, so that efficient management can be initiated prior to unalterable injure occurs. The primary aim of this study is to find out what factors play a significant role in determine the disease. From the brief account of discussion on observation and results of multivariate techniques are established, such techniques are important for they make it possible to encompass all the data from an investigation in one analysis. They in fact result in a clearer and better account...
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Posted by admin on Dec 31, 2017 in |
Doxofylline [7-(1,3-Dioxolan-2-ylmethyl) – 1,3-dimethyl purine-2,6-dione] is a Xanthine derivative drug used in the treatment of Asthma. The molecular formula is C11H14N4O4. Doxofylline is presently available in tablet form with high oral dosages of 400 mg, 800 mg and 1200 mg, Syrup with oral dosage of 100 mg/5mL and Suspension with oral dosage of 100 mg/5mL. It is also marketed as a combination drug with Terbutaline and Montelukast. Extensive literature survey revealed crystals with needle shape morphology. Novel crystal form (Form P) of Doxofylline with new rod shape morphology has been identified and fully characterized by a variety of analytical techniques such as Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimeter (DSC), Thermo Gravimetric Analysis (TGA) and Polarized Microscopy (PM). Since, rod shape crystals are preferable than needle shape crystals for filtrations in pharma manufacturing. The newly prepared novel crystal form (Form P) of Doxofylline with rod shape morphology is more suitable in Doxofylline...
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Posted by admin on Dec 31, 2017 in |
The present work focuses to check the acute and sub-acute toxicity studies of X42 fraction of Terminalia ivorensis in rats. Materials and methods: The acute toxicity of the extract was evaluated in rats. The rats were administered intraperitoneally the fraction at the dose of 50, 100, 200 and 300 mg/kg bw and recorded general symptoms and mortality. For sub acute toxicity, the rats received intraperitoneally, normal saline (control), 2.5; 5.0 and 10.0 mg/kg of the extract for 28 days. Animals were observed for general behavioral and signs of abnormalities during the experiment duration. The last day, blood was taken for hematological and biochemical analysis. The liver, kidney, and heart tissues were weighed. Results: Acute toxicity study produced dose dependent mortality with median Lethal Dose (LD50) of 200 mg/kg. Repeated administration of fraction caused no mortality. There were no significant changes (p>0.05) observed in serum biochemical markers, hematological markers, body weight changed, relative organs weight when compared to control group. Conclusion: The results show that the extract of T. ivorensis...
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Posted by admin on Dec 31, 2017 in |
Clopidogrel bisulphate is a drug used in inhibiting the platelet aggregation and also used in the treatment of cardiovascular disorders. It acts by inhibiting the adenosine diphosphate and is almost absorbed (98%) after oral administration. Approximately 50 % of drug is excreted in urine and 40% in feces. The plasma half life of drug is about 8 hours which makes frequent dosing necessary to maintain the therapeutic blood levels of drug for a long term treatment. So the transdermal patches were used to deliver the drug directly to systemic circulation through skin. The transdermal patches were prepared by solvent evaporation method. The influence of varying the combination of polymer concentrations at different ratio was evaluated. The polymers used in this study did not alter physicochemical properties of the drug. All the batches were evaluated for physical appearance, thickness, weight variation and drug content uniformity. The in-vitro drug dissolution study was carried out using Franz diffusion apparatus and the release mechanisms were explored. Mean dissolution time is used to characterize...
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Posted by admin on Dec 31, 2017 in |
The aim of present study on Spirulina platensis (Spirulina) was to evaluate the anti-stress activity. The anti-stress activity was assessed by tail suspension method andcold immobilization induced change of biochemical parameters. Acute toxicity (LD50) of Spirulina platensis values was also studied. Duration of immobilization time and cold immobilization induced alteration of biochemical parameters (liver functioning profiles like- AST, ALT, ALP and liver tissue anti-oxidant profiles like- MDA, SOD, GST) were used as a stress indicator. Spirulina platensis administered orally at two different doses of 200 and 400 mg/kg respectively. Diazepam, a well-known anti- stress drug (2 mg/kg i.p.) was taken as standard drug. The dose of 200 and 400 mg/kg of Spirulina Platensis significantly decreased the duration of immobilization time and also provide protection against stress induced alteration of biochemical parameters. It is concluded that the 200 and 400 mg/kg dose of Spirulina platensis have anti-stress...
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