Posted by admin on Dec 31, 2017 in |
The study was conducted to study biochemical parameters in 42 major depressive disorder (MDD) patients, 22 males and 20 females (age range 18 – 55 years) visiting the Psychiatric Department, Government Medical College, Jammu. The smoking and alcohol intake was much lower (95.24% and 88.09%) in patients (both male and female) diagnosed with MDD. The well being status is also 76.19% satisfactory with 71.43% patients with no family history of psychiatry illness and 73.81% with absence of chronic morbidity. The levels of thyroid stimulating hormone (TSH), ferritin and insulin are in normal reference range while the Vitamin B and Vitamin D 25OH levels are observed to be lower in 54.76% patients. The present study concluded that there is need for awareness towards these biomarkers as they play an important role in brain functioning by planning awareness programs. Therefore, further study with large sample size to evaluate these biochemical parameters and other risk factors is required to mitigate the effect of depression in the population of...
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Posted by admin on Dec 31, 2017 in |
4-Aryl-hexahydroquinolines in vitro antioxidant properties were evaluated by spectrophotometric method. This method is based on the charge transfer complex which is formed between 4-aryl-hexahydroquinolines and chloranil. AM1 and PM3 semi empirical methods were used to estimate different physicochemical parameters. The antioxidant activity was correlated with these physicochemical parameters and different QSAR models were generated. Docking studies were also performed in the active site of prenyl transferase to identify the structural features of the antioxidants. Docking scores with appreciable binding energy values also exactly correlated with the experimental activity. The chemscore estimated by Gold Software was found to have a good correlation with the experimental activity. The Docking and QSAR results reveal that the electron donating substituents on benzene ring were responsible to improve the antioxidant activity of the...
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Posted by admin on Dec 31, 2017 in |
Cisplatin is a cytotoxic drug which induced the hepatotoxicity in the albino mice when intra-peritoneally administered at the dose of 10 mg/kg. Administration of cisplatin raised the level of LFT’s enzymes and also reduced the level of antioxidant enzymes in the liver of the mice. Administration of Cuminum cyminum and Nigella sativa extract and silymarin remarkably showed the hepatoprotective effect in the albino mice. Administration of C. cyminum, N. sativa and silymarin decreased the level of ALT, AST, and ALP along with increasing the level of total protein content. It also increased the level of antioxidant enzymes in the liver of albino mice showing its hepatoprotective activity. We found N. sativa has a better hepatoprotective and antioxidant effect than C....
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Posted by admin on Dec 31, 2017 in |
A sensitive, precise and accurate reverse phase high performance liquid chromatographic method (RP-HPLC) using an isocratic elution of 0.1 M NaH2PO4 (pH 3.0) and acetonitrile (80:20 v/v) with a flow rate of 1.0 mL/min, a column temperature of 30 °C and UV detection at 254 nm was developed for the estimation of metformin and benfotiamine simultaneously. The method was validated following guidelines given by International Conference Harmonization. The method allowed the determination of metformin and benfotiamine in the concentration range of 100-300 μg/mL and 15-45 μg/mL, respectively. The limit of detection & limit of quantification were 0.290 μg/mL & 0.968 μg/mL for metformin and 0.047 μg/mL & 0.156 μg/mL for benfotiamine, respectively. The percent relative standard deviation (%RSD) value was 0.067 % for metformin and 0.047 % for benfotiamine. The accuracies were 99.510 – 99.797% and 9.652 – 99.890% for metformin and benfotiamine, respectively. The developed and validated RP-HPLC method was applied successfully for the quantification of metformin and benfotiamine simultaneously in tablet dosage form. Common excipients in the...
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Posted by admin on Dec 31, 2017 in |
Morinda citrifolia L. (Rubeaceae) is a medicinal plant commonly called as Noni. Traditionally the entire plant is used for the treatment of cancer, inflammation, hypertension, diabetes, bacterial infections, and arthritis. The present study aims to explore the antineoplastic activity of Noni Juice (NJ) and Divine Noni Gold (DNG) concentrate on Ehrlich ascites carcinoma (EAC) bearing mice. Antineoplastic activity of NJ and DNG was evaluated in EAC bearing mice by administrating 0.35 ml/mouse p.o. respectively once daily for 14 days, before half an hour of NJ and DNG administration animal received single dose of cisplatin (CP) at the dose of 5.0 mg/kg b.w. i.p. on day 1 in respective cluster. Antitumor activity of NJ and DNG were measured by evaluating Mean Survival Time (MST), percentage Increase in Life Span (%ILS), body weight, tumor volume and viable cell count, additionally biochemical markers as well as hematological parameters were also evaluated. In the result, observed NJ and DNG respectively showed significant decrease tumor volume, viable cell count, body weight and raised MST...
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