Posted by admin on Nov 30, 2017 in |
Present studies describe the synthesis of a series of Schiff base derived quinazolinone derivatives (6-14) with the aim to have better anti inflammatory agents. The prepared compounds were characterized using chemical and spectral (IR, NMR and Mass) studies. Pharmacological evaluation of the newly synthesized derivatives indicated that compounds 8, 11 and 14 exhibit significant anti-inflammatory activity in carrageenan-induced rat paw oedema assay, and their effects are found to be comparable that of standard drug Indomethacin. Molecular docking studies were further employed to investigate the binding interactions to COX-2 active site residues and to study the stability of docked conformation in detail. The experimentally determined COX-2 inhibitory activity was found to be well correlating with binding modes predicted for compounds by GLIDE dock scoring function. The 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-one pharmacophore reported herein represents a new lead for further development of novel non-steroidal anti-inflammatory...
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Posted by admin on Nov 30, 2017 in |
Nature is always being a consistent and constant source of medicinal substances for prevention and cure of various ailments, including the helminth infections, which is one of the health problems that affect human and livestock in the world. Because of limited availability/ accessibility of anthelmintic compounds in modern medicine, and reawakened worldwide interest in plants based medicine, the present study was undertaken to evaluate the anthelmintic activity of the stem bark of Plumeria rubra (Syn. Plumeria acutifolia) along with the qualitative and quantitative estimation of phytochemicals present in the stem bark of P. rubra, family Apocynaceae – one of the ten largest angiosperm families and comprises of several prominent medicinal plants. Out of five extracts prepared, the methanolic extract showed better yield and hence used for the present study. Preliminary phytochemical investigation reflected the presence of many phytoconstituents, mainly – alkaloids, glycosides, tannin, terpenes, flavonoid, phenol, saponin. The in-vitro anthelmintic study of stem bark extract of P. rubra with reference to standard Piperazine citrate showed prominent results in concentration...
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Posted by admin on Nov 30, 2017 in |
Worldwide scientists are focusing on developing functional food products which are healthy and low in calories. The possibility of incorporating roasted flax seeds flour (RFF) and substituting sugar with Stevia rebaudiana leaves powder (SLP) for developing nutritious, healthier and high quality biscuits has been investigated. Overall six biscuit formulations were designed besides control. SLP was used as a natural sweetener and RFF was used as a source of dietary fibre. Standardisation was done by evaluating the sensory quality of the formulated biscuits prepared from a mixture of blends. As soon as standardisation of blends was completed, the standardised flour mix was used to formulate biscuits by substituting sucrose with SLP at levels of 5.5%, 6%, 6.5%, 7%, 7.5% and 8%. The treatment (T4) was found to be the best among different variations on the basis of sensory evaluation with incorporation of 8% (RFF) and 7% (SLP) resulted in increased moisture (7.57%), ash (3.69%), protein (18.88 g/100g), fat (10.97 g/100g), fibre (4.52 g/100g), calcium (408.23 mg/100g), phosphorus (445.03 mg/100g) and...
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Posted by admin on Nov 30, 2017 in |
Epilepsy is a neurological disorder which often requires lifelong treatment with antiepileptic drugs (AEDs). Prolonged use of AEDs is associated with changes in vascular risk markers. Hence, the study was designed to evaluate the effect of older generation AEDs (carbamazepine and phenytoin) and newer generation AED (levetiracetam) monotherapy on the markers of vascular risk in epilepsy patients. This study was carried out in the neurology department of a tertiary care hospital for a period of 7 months. Clinical and biochemistry reports of 90 patients were collected in designed case report forms. All statistical analyses were performed using IBM Statistical Package for Social Sciences (SPSS) 17 and Graph Pad Prism 7.0. We observed statistically significant changes in the lipid profile and C-reactive protein (CRP) in carbamazepine and phenytoin received groups. We did not observe any statistically significant difference in the above parameters in levetiracetam group. Thus, careful monitoring of the serum lipid profile and CRP at regular intervals throughout the treatment course is considered necessary in epileptic patients undergoing long-term...
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Posted by admin on Nov 30, 2017 in |
Arcuate nucleus GABAergic system plays an important role in the energy balance evidenced by various studies. The present study was designed to investigate the involvement of GABA type A receptor in experimental obesity. In the present study effects of chronic administration of diazepam (0.5 and 1mg/kg/day, i.p) and bicuculline (0.6 and 1.25mg/kg/day, i.p) specific GABA type A receptor agonist and antagonist respectively for 8 weeks along with high fat diet to the obese rats which were pre-treated with high fat diet feeding for 8 weeks on the various parameters of obesity were analysed. Treatment with bicuculline (0.6 and 1.25mg/kg/day, i.p) produced significant dose dependent decrease (p < 0.05) in various parameters of obesity as compared to high fat diet group. Diazepam (0.5 and 1mg/kg/day, i.p) produced dose dependent increase in the feeding behaviour in experimental obese rats, while the other parameters were not significantly altered with chronic administration of diazepam as compared to high fat diet control group. Diazepam a negatively alter the parameters of obesity, while the bicuculline...
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