Posted by admin on Aug 31, 2017 in |
Self nano-emulsifying system drug delivery system (SNEDDS) is promising for drugs of BCS class II. The objective of present study to develop self nano-emulsifying drug delivery system for Lipophillic drug Telmisartan (antihypertensive drug), labrafil 1944, Kolliphor ELP: Span 80 (1:1) and PEG 400: Ethanol (1:1) was chosen as oil, Surfactant and Co-surfactant as they show higher solubility for Telmisartan. Screening of Surfactant, Co-surfactant done by percent transmittance and were also observed for turbidity or phase separation visually. Pseudo ternary phase diagram were constructed to identify the self emulsifying regions and also to establish the optimum concentration of oil, surfactant and co-surfactant. Box bhenken desine applied for optimization of formulation. Prepared formulation further Characterization done. Percent Drug Content found 99.71, thermodynamic stability studies show homogenous and no phase separation, Emulsifying Study performed transparent appearance after 24 hr, for robustness Dilutability in water and 0.1N HCl give Percentage Transmittance 99.5 and 100, conducting in vitro dissolution test compared with marketed preparation in stimulated gastric (S.G.F) pH 1.2 showed Percent Drug Release...
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Posted by admin on Aug 31, 2017 in |
2, 6-dithiol-4-methylphenol (DTMP) is proposed as an analytical reagent for the extractive spectrophotometric determination of molybdenum (V). DTMP in the presence 2, 6- bis (N, N-dimethylaminomethyl)-4-methylphenol (AP) forms red colored complex with molybdenum (V) in the pH range 4.8 – 5.8. The Beer’s law was applicable in the range 0.4-22μg mL−1. The dark red Mo-DTMP-AP complex shows a maximum absorbance at 525 nm, with molar absorptivity of 5.21× 104 dm3 mol−1 cm−1 and Sandell’s sensitivity of the complex obtained from Beer’s data is 1.84 ng cm-2. The composition of the Mo (V)-DTMP-AP complex is found to be 1:2:1 (Mo: DTMP: AP). The interference of various cations and anions in the method were studied. The results of the prescribed procedure applied for the determination of the micro amounts of Mo (V) in plant, water and soil samples are...
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Posted by admin on Aug 31, 2017 in |
Context: Ziziphus mistol (mistol) fruits and their derivate product (arrope) have been traditionally used as food and in folk medicine for the treatment of a wide variety of diseases including bronchopulmonary disorder. Objective: The objective of this study is to evaluate the antitussive and expectorant effects of Z. mistol ethanol extract (EE), aqueous extract (AE) and arrope (Ar). Materials and Methods: The antitussive activity was evaluated using two models against ammonia and citric acid induced cough in rats. The expectorant activity was evaluated by volume of phenol red secretion in rats’ tracheas. The tested doses of extracts were of 250, 500 and 1000 mg/kg, (p.o.). Results: The aqueous extract and arrope showed the highest activity in all tested models. The arrope, at 1000 mg / kg, proved to be more effective with inhibitions of 79.69% and 93.75% in the number of coughs induced by ammonium liqueur and citric acid, respectively, while it was similar to codeine. Expectorant activity showed an 87.73% increase in red phenol secretion at the same dose,...
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Posted by admin on Aug 31, 2017 in |
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases and improper immune development. The main objective of the present research work was the synthesis of N-(4-{[5-(substituted phenyl)-1,3,4-oxadiazol-2-yl] methoxy}phenyl) acetamide derivatives and to evaluate the hepatocytes regenerator potentiality by molecular docking with 2V2T-NF-KB and as well as In vivo methods and the synthesized compounds were characterized by IR, NMR, and Mass spectroscopy. The in-vivo Hepatoprotective activity was carried out by using albino rats where CCl4 was used as a hepatotoxin. Molecular docking is performed to find out the binding affinity or molecular interaction energy (kcal/mol) of docked compounds. In silico molecular docking studies displayed the binding energies: -5.17, -5.52, -5.40, -4.60, -4.60, -4.87, -3.42, -3.85 k.cal/mol, of the synthesized compounds (AB1-AB8) which indicated that the compound had the high binding affinity towards the 2V2T-NF-KB protein and inhibit the NF-KB protein function in comparison with...
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Posted by admin on Aug 31, 2017 in |
Aging is among the phenomena more commonly discussed in world health in recent years. Disability is a good indicator to measure health status in the aging population. Accordingly, the primary objective of this study was to determine the prevalence of disability and its relationship with demographic characteristics of the elderly in Zahedan city in Iran in 2016. This is a cross-sectional descriptive-analytic study. Using two-stage random sampling, 400 seniors were selected in Zahedan and were studied. A researcher made questionnaire was used to collect demographic information and disability study instruments included WHODAS – 36 items without time code. Collected data were analyzed using the SPSS version 16 software using the chi-square test. Of 400, 218 individuals were female and182ones were male and the mean age of the participant’s was 73.21 ± 6.82 years old. The overall prevalence of disability among the elderly in Zahedan was 62.3%. The prevalence of disability had a significant relationship with age, education, occupation and income level (p < 0.05), whereas no relationship was observed...
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