Posted by admin on Sep 30, 2017 in |
Bombax ceiba Linn. is one of the important plant species used in various system of medicine. Almost every part of plant is used as medicine and its roots and flowers are used for curing maximum number of ailments. Leaves of the plants are also containing different important secondary metabolites. For the use as safe herbal medicine the plant material (leaves) has to be standardized with the establishment of a consistent biological activity. Pharmacognistic studies includes different Physicochemical parameters like Proximate analysis of plant material such as Fluorescence Analysis, percentage of loss on drying (Moisture content), Total ash, Acid Insoluble ash, Water Soluble ash, used for the standardization, as per guideline of the in Indian Pharmacopoeia. Evaluation of drug in this ways was done for the confirmation of its identity and determination of its quality and purity and detection of nature of adulteration. Sterols present in plant called as Phytosterols. Phytoesterols with the principle advantage that inhibit the absorption of cholesterol and lower serum cholesterol levels was detected by basic...
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Posted by admin on Sep 30, 2017 in |
Modification of a drug molecule of a series having optimal activity is widely used and continues to be an important factor necessary for new drug discovery. Infectious diseases which increase dramatically by resistant and multi resistant microbes are now a days the second major cause of death worldwide and the third leading cause of death in the developed countries. Although, the search for new lead structures for the development of antimicrobial agent is an increasingly important problem in medicinal chemistry. The treatment of infectious diseases still remains an important and challenging area of research due to multidrug resistance by microbes. The increasing incident of drug resistance in treatment of microbial diseases emphasizes worldwide need for newer antimicrobial agents. To treat these infectious diseases, a route is established to synthesize the pharmacological active novel chromone based sulfonamide derivatives i.e. substituted N- (3 –formyl -4-oxo -4H –chromen -2-yl) -N-phenyl benzene sulfonamide having antibacterial and antifungal activities. The objectives of the present work are: 1) To synthesize various derivatives of substituted N-(3-formyl-4-oxo-4H-chromen-2-yl)-N-phenyl...
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Posted by admin on Sep 30, 2017 in |
Type 2 diabetes (T2D) is one of the risk factor for dry eye disease (DED) and known factor for diabetic retinopathy (DR). There are few studies have been already reported the prevalence of DED nevertheless studies shown prevalence of DED and DR by sex in patients with T2D. The study was carried out with 100 T2D patients. DED was assessed with Tear break up time and Schirmer tests. All the subjects were examined by slit lamp bio-microscopy and colored fundus photographs. Diabetic retinopathy (DR) was graded according to early Treatment Diabetic Retinopathy (ETDRS) criteria. Out of 100 T2D patients, the prevalence of DED was noticed in 53 patients. Out of 53 DED cases, 14 (43.8%) were males and 39 (57.4%) were females. Next we assessed the association of DED with DR and it was found 47.6% in males and 69.4% in females. In our study, the prevalence of DED was high in T2D patients and showed to have a high correlation with DR. Prevalence of DED was more in...
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Posted by admin on Sep 30, 2017 in |
Polymer functionalised mesoporous silica nanoparticles hold great promise to enhance drug targeting and cell internalisation for cancer cells. Since the presence of abundant folate receptors on cancer cells, folic acid functionalised mesoporous silica nanoparticles (MSN) were used as folate marker and polyethyleneimine was used to improve cell internalisation. Meloxicam was loaded into the pores of nanoparticles through –NH2 linker and polyethyleneimine-folic acid was grafted onto mesoporous silica nanoparticles. The functionalised MSN were characterised for particle size, surface charge, and elemental analysis. The release of meloxicam from the functionalised nanoparticles exhibited sustained release through membrane diffusion drug release method. Cell viability and cytotoxicity study was performed using HT-29 Human Colon cancer cell line as an in-vitro model. The results of scanning electron microscopy and energy dispersive spectroscopy demonstrated the presence of SiO2 group and the particle size of functionalised nanoparticles to be between 200-800 nm. The zeta potential of the coated MSN exhibited positive surface charge, enhancing the targeting of negatively charged cancer cells and cell internalisation. Moreover, the cytotoxicity...
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Posted by admin on Sep 30, 2017 in |
Medicinal plants continue to be an important therapeutic aid for alleviating the ailments of human kind. The plant Dalbergia sissoo contains various chemical constituent with specific value in ethno-medicinal practices and has significance in the field of health care system. The main objective of this study involves the evaluation of anti-bacterial activity of D. sissoo leaves and barks extracts of chloroform, ethyl acetate, acetone and methanol. The assay was done by bioassay guided fractionation by disc diffusion method on both Staphylococcus aureus (gram-positive) and Escherichia coli (gram-negative) bacteria using Ampicillin for S. aureus and Norfloxacin for E. coli as positive control and DMSO (Dimethyl Sulphoxide) as a negative control. The anti-bacterial activity of methanol extracts of leaves was found to be more as compared to other extracts. S. aureus was found to be more susceptible to plant extracts than E. coli. Thus, the results obtained confirm the therapeutic potency of D. sissoo used in traditional...
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