Posted by admin on Mar 31, 2017 in |
A simple, accurate, precise and easy spectrophotometric method for the determination of levetiracetam in pharmaceutical formulations using molybdenum blue method was developed by the authors. Aqueous solution of the drug sample on reaction with ammonium molybdate solution and hydrazine sulphate solution on heating for 5 minutes at a temperature of 60 0 C gave a clear, stable and intense blue colored molybdenum blue complex. This molybdenum blue showed a λmax at 823nm. Beer’s law was found to be obeyed in the range 0.02-0.08mg/ml. correlation coefficient was found to be 0.998. Molar abosrptivity was found to be 240.2 lit/mole/cm. LOD and LOQ was found to be 0.12 mg/ml and 0.37mg/ml respectively. The method is important in view of the fact that the excess dosage causes clinical problems and optimum dosage has to be fixed in the use of the...
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Posted by admin on Mar 31, 2017 in |
In this study, the plant Glycyrrhiza glabra was explored for the synthesis of silver nanoparticles (SNPs). The SNPs were characterised by ultra-violet-visible spectroscopy, FTIR analysis and scanning electron microscopy. SEM analysis revealed the formation of SNPs of average size of 46 nm with aqueous extract of G. glabra. The SNPs synthesised by aqueous extract of G. glabra showed strong antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa and significant inhibition to other bacteria and few fungi tested. The SNPs also exhibited potential anti cancer activity. The SNPs was observed to be nontoxic from a concentration of 500 µg/ml in vero cell line. The results document SNPs can be synthesised using aqueous plant extracts for applications in the biomedical...
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Posted by admin on Mar 31, 2017 in |
Prodrug approach is a new frontier that reinforces the concept of green chemistry in the pharmaceutical chemistry field. The combination of a suitable synthesis and the strategy of the prodrug is of huge advantage for pharmaceutical industries. In this paper, we compare the conventional synthesis of new galactosylated NSAIDs prodrugs with green strategies and demonstrate how we can move away from the use of harmful substances using a suitable method for the synthesis of new compounds. So, we decided to investigate the use of potentially cleaner solvents and reagents such as room temperature ionic liquids, hydrochloric acid and glacial acetic acid. Furthermore, the chemical and enzymatic stabilities of new NSAIDs prodrugs were evaluated in order to determine both their stability in an aqueous solution at pH=1 and pH=7.4 and their feasibility in undergoing enzymatic cleavage by plasma to regenerate the original drug. Results concerning green synthetic approach clearly showed a reduction of time and waste. Moreover, these prodrugs are susceptible to degradation in rat plasma but stable to chemical...
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Posted by admin on Mar 31, 2017 in |
Objective: PCOS is a common endocrine disorder in women of reproductive age associated with insulin resistance. Metformin and Myo-inositol being insulin sensitizers improve biochemical parameters. This study was done to compare the effects of these drugs on biochemical profile in PCOS. Material and Methods: A prospective, open labeled, randomized, comparative, clinical study was conducted on 60 patients. The patients were randomly divided in two groups of 30 each to receive either of the following two treatments: Group A: Tab Myo-inositol 1g twice daily & Group B: Tab Metformin 500 mg thrice daily for 24 weeks. Biochemical profile was assessed by measuring fasting blood sugar, insulin levels & calculating glucose/insulin ratio and homeostatic model assessment- insulin resistance (HOMA-IR) index at baseline and subsequently at the end of 12 & 24 weeks. Serum Lipid profile was also assessed. Results: In both the groups, there was statistically significant improvement in insulin resistance. In group A & group B, the values for glucose/ insulin ratio improved from 6.77±0.99 to 7.87±1.03 and 5.5±0.42 to...
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Posted by admin on Mar 31, 2017 in |
Trigonella foenum (T. foenum), Trachyspermum copticum (T. copticum) and Nigella sativa (N. sativa) are important medicinal plants that need to be explored for their anti-oxidant potential. The aim of the present study was to evaluate the total anti-oxidant potential of methanolic extracts of T. foenum, T. copticum, N. sativa and the combination of these methanolic extracts in 1:1:1 ratio (Combination 1:1:1). The total phenolic content of the methanolic extracts of T. foenum, T. copticum, N. sativa and the Combination 1:1:1 was evaluated. Further the total anti-oxidant activity of the extracts was assessed by determining their total reducing capacity, DPPH radical scavenging activity and lipid peroxidation inhibition potential. The total reducing capacity was found to be 75.61, 115, 110.97 and 128.65 equivalents of ascorbic acid (μg)/mg for extract of T. foenum, T. copticum, N. sativa, Combination 1:1:1 respectively. The IC50 for DPPH radical scavenging activity obtained for T. foenum, T. copticum, N. sativa and Combination 1:1:1 was 2428.45, 316.18, 457.94 and 107.85 µg/ml respectively. The inhibition potential of lipid peroxidation...
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