Posted by admin on Feb 28, 2017 in |
Impaired carbohydrate and lipid metabolism with amplified oxidative stress are well recognized factors for Coronary artery disease (CAD) which is the major reason of mortality and morbidity all over world. The incident of CAD with type 2 diabetes mellitus (T2DM) is growing and they are predicted to be the biggest cause of death by 2020 in India. Therefore, the venture of the present study was to assess the association of hyperglycemia, oxidative stress, antioxidant enzymes, lipid profile and lipoprotein components in serum of CAD with T2DM patients as well as to compare the results with age-sex matched healthy human volunteers. Five hundred participants were enrolled for the present study, with their ages ranging from 37 to 57 years from OPD of medicine, Era’s Lucknow Medical College & Hospital, Lucknow, were attending OPD for routine medical checkup. Out of which two hundred fifty were clinically new diagnosed case of CAD with T2DM like hyperglycemia, angina pectoris and Myocardial infarction (MI), remaining two hundred fifty were healthy controls. All biochemical assays...
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Posted by admin on Feb 28, 2017 in |
Aims: To evaluate and analyze effectiveness of animal simulation based teaching in pharmacology in comparison to conventional methods to undergraduate medical students. Methods: An interventional and comparative study was conducted among second professional MBBS students. All students were divided into two groups A and B. Four demonstrations of experimental pharmacology were demonstrated by conventional method and animal simulation method by same teacher. Both groups were equally exposed to both modes of demonstrations. Every demonstration was followed by an assessment containing thirty objective type questions. Feedback was taken to analyze generalized opinion about the programme on likert’s scale. The data was analyzed by using Fisher’s exact test and p value calculated. Results: Percentage of students who scored 60% or more was higher in simulator based teaching in assessment related to procedure, related pharmacology and applied pharmacology. The difference between total scores of both groups in all four demonstrations was statistically significant with p value < 0.05. In feedback, percentage of students who opted three or more on likert scale was...
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Posted by admin on Feb 28, 2017 in |
Background: Metabolic syndrome (MetS) is a cluster of diseases, including hypertension, obesity, dyslipidemia, and hyperglycemia. We therefore aimed to estimate MetS prevalence and to determine risk factors for MetS. Methods: In the present study, we recruited 209 adult Tunisian MetS patients (57 males and 152 females, mean age 58.9±10.7 years) matched by gender and ethnic origin to 193 healthy individuals (31males and 162 females, mean age 50.3±10.6 years). All subjects underwent anthropometric and biochemical examinations. Results: Interestingly, the prevalence of MetS was 21.89% in males and 78.1% in females. Notable increase in the dyslipidemia (64.1%), hypertension (77%), and obesity (83.73%) in patients with MetS were seen. In addition, insulin resistance, hyperglycemia, abnormal lipid profiles, increased free fatty acids, and lower serum adiponectin concentrations were all associated with MetS. Conclusion: We suggest that the MetS is highly prevalent among patients group than healthy subjects. Modification of lifestyle factors, even later in life, has considerable potential for primary prevention of the...
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Posted by admin on Feb 28, 2017 in |
Objective: To evaluate drug utilization pattern among geriatric patients in outdoor as well as indoor departments of the hospital. Methods: Observational, prospective study was conducted from March 2014 to March 2015 among 600 geriatric patients; demographic details, education, occupation, diagnosis and drug details were recorded. The drugs were categorized by anatomical therapeutic classification and defined daily dose was calculated. The World Health Organization prescribing indicators and potentially inappropriate medicines (PIMs) according to Beers criteria were assessed. Results: The majority of the patients (75%) were in age group of 65-74 years. Cardiovascular diseases were common among geriatrics. Most commonly prescribed drug was ranitidine (56%). Comorbid conditions were present in 34.5% patients. In OPD and IPD 8.9% and 4.9% of drugs were fixed-dose combinations (FDCs) respectively. The mean number of drug formulations per prescriptions was 4.49±0.7 in OPD and 7.1±2.28 in IPD. Polypharmacy was prevalent in 62.5% of patients. Drugs prescribed by their generic names were 71.3% in OPD and 62.7% in IPD and 98% of were drugs that were included...
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Posted by admin on Feb 28, 2017 in |
Aim: The present study provides a scientific evaluation for the wound healing activity of methanolic extract of Ziziphus xylopyrus (Retz) Willd leaves (MEZX). Methods: Incision and excision wound models were used to evaluate the wound healing activity of MEZX on Wistar rats. In each model, animals were divided into four groups of 6 animals each. In both model, Group I was assigned as control (ointment base). Group II and III were treated with 5%w/w and 10% w/w MEZX topical ointment respectively. Group IV was treated with standard nitrofurazone ointment (0.2% w/w). The parameters recorded were percentage of wound contraction, epithelialisation period and tensile strength. Results: It was noted that the effect produced by MEZX ointment showed significant (P < 0.001) healing in all wound models when compared with the control group. All parameters such as wound contraction, epithelialisation period and tensile strength showed significant (P < 0.001) changes when compared with the control. MEZX stimulates wound contraction, decreases epithelialisation period and increases tensile strength. Conclusion: This study suggests that...
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