Posted by admin on Jan 31, 2017 in |
Due to your efforts diligent on quinoline nucleus new series containing pyrimido [4, 5-b] quinoline were synthesized via starting with the strategic 2-aminoquinoline-3-carbonitrile (2) intermediates to afford various pyrimido [4, 5-b] quinoline via cyclization with different reagents to get compounds 3-24. Compounds 3, 6, 9a, 9b, 12, 15, 16a, 16b, 17, 21 and 24 were tested for in vitro antitumor activity against human breast carcinoma (MCF-7) cell line, We found what we were hoping for where compound 6 was found the most active member (IC50= 48.54 μM) than the Doxorubicin as a reference drug with (IC50= 71.80 μM). To understand the interaction of binding sites with the target protein receptor, the docking study was performed using topoisomerase II. The results of in vitro cancer activity and docking study revealed that the synthesized compounds have potential cancer activity and can be further optimized and developed as a lead...
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Posted by admin on Dec 31, 2016 in |
Proniosomes based drug delivery systems have potential as a significant drug carrier in a variety of therapeutic applications. The objective of the present study was to investigate in vitro sonophoretic transdermal delivery of Losartan Potassium (LP) across albino rat skin using proniosomal gel and its comparison with aquasonic gel. Proniosomes of LP were fabricated with L-a-lecithin (egg yolk), cholesterol and a non-ionic surfactant and confirmed using optical microscopy. Permeation experiments were performed using modified Franz Diffusion Cell along with ultrasound treatment (Frequency-1MHz; Intensity- 2.5 W/cm2; Duration of application- 30 min; Mode of application – Continuous and Pulsed). An in vitro skin permeation of LP with aquasonic gel was found superior than proniosomal gel using sonophoretic delivery. Using proniosomal gel, when ultrasound was applied in pulsed mode, LP transdermal flux and enhancement factor were 60.88 ± 6.2 μg/cm2/h and 5.31, respectively, 115.41 ± 5.01 μg/cm2/h and 10.07 those achieved using aquasonic ultrasound gel, respectively. Similar results were observed (better flux with aquasonic gel than proniosomal gel) using continuous mode of...
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Posted by admin on Dec 31, 2016 in |
Anti-diabetic activity of hydro-alcoholic extract of Chrysophyllum cainito frutis (CCE) was investigated against experimentally induced diabetics in rats using alloxan and streptozotocin (STZ). Acute toxicity study was performed and hydro-alcoholic extract of CCE was found to be safe at a dose of 2000 mg/kg bodyweight. Two doses 200 mg/kg and 400 mg/kg b.w p.o. of the CCE were subjected for the evaluation of anti-diabetic activity against the diabetic induced by alloxan (100 mg/kg, i.p) and STZ (50 mg/kg, i.p) in rats. Glibenclamide (5 mg/kg p.o) was served as standard in both the models. Fasting blood glucose, serum total cholesterol, serum triglycerides, lipid profile (HDL and LDL) and histopathology were evaluated in the study. Both the lower (200 mg/kg) and higher dose (400 mg/kg) of CCE showed a dose dependent significant decrease in blood glucose level, triglyceride, cholesterol levels and LDL and an increase in HDL in the treated diabetic rats when compared with diabetic control. Histopathology of pancreas showed regeneration of β-cells in extract treated diabetic rats. The results...
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Posted by admin on Dec 31, 2016 in |
Preeclampsia usually develops systemic hypertension, proteinuria, coagulation abnormalities and eclampsia develops when convulsions superimpose on the syndrome of preeclampsia. Disturbed renal functions with elevated blood urea and serum creatinine levels were reported in various studies but, elevations of serum uric acid levels are controversial. The aim of the current study is to determine the renal function Parameters such as blood urea, serum creatinine and serum uric acid levels in preeclampsia patients and to compare it with the normal pregnant women. 100 subjects were selected with 50 controls and 50 preeclampsia cases. Renal function parameters are estimated in preeclampsia cases and controls (normal pregnant women). Statistical analysis was done. The study may be concluded that the uric acid levels are elevated along with urea and creatinine in preeclampsia compared to normal pregnancy...
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Posted by admin on Dec 31, 2016 in |
Plant extract-mediated biosynthesis of nanoparticles has proven to be a novel, rapid, cost-effective, non-toxic and eco-friendly method. For the first time, biological material in the form of aqueous extract of Annona muricata fruit (AMF) was successfully utilized for the synthesis of silver nanoparticles (AgNPs). The various parameters such as metal ion concentration, volume of the extract, temperature, reaction time and pH influencing nanoparticle synthesis have also been optimized. The structural and elemental components of the synthesized AgNPs were characterized. The UV-vis spectra gave surface plasmon resonance peak at 421nm. Fourier transform infrared spectroscopy (FTIR) revealed capping of nanoparticles with plant constituents. X-ray diffraction (XRD) demonstrated a face-centered crystalline nature with an average size of 19 nm. Field Emission scanning electron microscopy (FESEM) showed their spherical shape and the presence of elemental silver were determined by Energy Dispersive X-ray spectroscopy (EDX). Further, assessment of the antioxidant activity, total phenolic content and photocatalytic property of biogenic silver nanoparticles attest to their utility for several biomedical and industrial...
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