Posted by admin on Feb 28, 2017 in |
Objectives: The study aimed at evaluating the broncho-relaxant effect of the test drug Flupirtine in experimentally induced Asthma in Guinea pigs & compares its efficacy with the Standard. Materials and Methods: Guinea pigs of both sexes weighing around 350-400 gm were randomly divided into 3 groups of 6 animals each. Groups were categorised into Control, Standard and test groups. Animals serving as controls received 10 ml/kg body weight of Normal saline; Standard group received 4.5 mg/kg body weight of salbutamol & the test group received the test drug flupirtine in doses of 46.5 mg/kg of body weight. All the compounds were administered once a day, per orally, through a gavage tube for 5 days. On day 5 experimental bronchial asthma was induced by exposing animals to 0.25% histamine acid phosphate under constant pressure (40mm/Hg) in an aerosol chamber. Animals exposed to histamine aerosol developed progressive dyspnoea. Pre-convulsive time (PCT) was determined from the time of exposure to onset of dyspnoea, immediately before the appearance of convulsions. Greater the PCT...
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Posted by admin on Feb 28, 2017 in |
The purpose of the present investigation is to formulate and evaluate Lercanidipine pulsatile drug delivery system by press coating method. The inner core tablets were prepared by using direct compression method by using cross-carmellose sodium (Ac-Di-Sol), sodium starch glycolate, crospovidone as super disintegrants. The drug polymer interaction was investigated by FTIR and their results directed further course of formulation. The inner core tablets were evaluated for various post compression parameters like Tablet hardness, Friability, Weight variation, Drug content and in vitro dissolution for both core and coated Tablets. The disintegration time for the core tablet was found to be 35sec and the percentage drug release for the optimized formulation (F7) was 96.1% in 30mins. The Press coat tablets containing HPMC and Ethyl cellulose as a barrier layer. The press coat tablets were evaluated for post compression parameters and were found to be in limits. The percentage drug release of optimized formulation Ethyl cellulose (F7P3) was found to 99.65% at the end of...
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Posted by admin on Feb 28, 2017 in |
The kinetics and mechanism of oxidation of Phenylephrine (PHE) by Chloramine-T (CAT) in acid media have been investigated by spectroscopic technique at the temperature of 298 K. It is found that the reaction is of first order with respect to PHE, fractional order with respect to CAT & inverse order with respect to H+. The reaction rate remained unchanged with the variation of ionic strength of the medium indicating that the non ionic species are involved in the rate determining step. The rate of reaction decreases with increase in concentration of dielectric constant. Addition of chloride ions had no effect on rate of reaction. The stoichiometric ratio was found to be 1:1(PHE: CAT) ratio. The major oxidation product of PHE has been identified by an UV, Cyclic voltammetry (CV), IR, H1 NMR and Mass spectroscopy. On the basis of the experimental results, a suitable mechanism has been proposed. The rate constants of the rate-determining step together with the activation parameters were evaluated and also thermodynamic quantities were...
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Posted by admin on Feb 28, 2017 in |
Breadfruit (Artocarpus altilis (Parkinson) Fosberg) empirically has been used in certain communities in Indonesia as a traditional medicine. Biosynthesis process can change colour leaves of breadfruit from green leaves (GL), yellow leaves (YL), fallen yellow (FY), fallen dry (FD), and the process fermentation of green leaves become fermented green (FG). The purpose of this study was to determine whether the methanol extract of breadfruit leaves variations have activity to Escherichia coli, Staphylococcus epidermidis, Propionibacterium acnes and Candida albicans and determination of Minimum Inhibitory Concentration (MIC). Simplicia was processing maseration used methanol, phytochemical screening on the fifth methanol extracts, botanicals characterization, activity test against to Escherichia coli, Staphylococcus epidermidis, Propionibacterium acnes, and activity test against to Candida albicans. Active extracts determined Minimum Inhibitory Content (MIC) and TLC. MIC used agar diffusion method. The test results showed antibacterial and antifungal activity variations of fermented green gives effective results than other breadfruit leaf variations. MIC values for the bacterium Escherichia coli, Staphylococcus epidermidis, Propionibacterium acnes, and the Fungi Candida albicans in a...
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Posted by admin on Feb 28, 2017 in |
In the present work ethanol, methanol, ethyl acetate, chloroform and benzene extract of the Michaelia champaca leaves were screened for their antimicrobial activity. The ethanolic extracts of M. champaca leaves were proved to have the maximum antimicrobial activity; thus the ethanolic leaf extract was selected and the nanoparticles were synthesized using ionic gelification method. The nanoparticles were characterized physically and chemically using TEM and FTIR respectively. The herbal extract loaded nanopartricles were coated on to the non woven cotton fabric using the pad dry cure method. The antimicrobial activity of the untreated and treated (M. champaca leaf extracts coated fabric and leaf extract loaded nanoparticles coated fabric) fabric were assessed by the standard AATCC 147, AATCC 30 and laundering durability. The herbal leaf extract loaded nanoparticles coated fabric showed the better antimicrobial activity and particularly highest wash durability when compared with other treated fabric. The controlled and sustained releasing property of the herb extract loaded nanoparticles could be attributed to its very effective antimicrobial activity. These particles could further...
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