Posted by admin on Dec 31, 2016 in |
A simple, selective, rapid, precise reverse phase high pressure liquid chromatographic method has been developed for the simultaneous estimation of Hydrochlorothiazide, Amlodipine besylate and Telmisartan in tablet dosage form as per ICH guidelines. The wavelength selected for the analysis was 239 nm for amlodipine besylate, telmisartan and hydrochlorothiazide. The solvents used were methanol and distilled water. The mobile phase 0.05M Potassium dihydrogen ortho-phosphate (pH-3.2), acetonitrile and methanol in the ratio 45:45:10 was used to carry out the separation. Column used was Supelco C18 (250 x 4.6 mm, 5μ). Flow rate was selected as 1ml/min. Retention time for Hydrochlorothizide (HCT), Amlodipine besylate (AML) and Telmisartan (TEL) was found to be 2.9min., 5.1min., 8.2min. The developed method was validated for accuracy, precision, linearity, robustness, ruggedness, specificity. The proposed method can be used for the estimation of these drugs in combined dosage...
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Posted by admin on Dec 31, 2016 in |
Awareness of reproductive health is rights of humans and lack of accurate notification will lead to numerous complications.Pre-marriage is one of the best times to training of these issues. Therefore, this study was done in order to evaluation the effects of premarital education on the girls’ awareness about reproductive health. In this semi-experimental study, 152of womens that participated in courses at marriage counseling center were selected with consecutive sampling method in Garmsar city, Iran in 2012.Data were collected by a questionnaire containing demographic (contains two sections: demographic characteristics and reproductive health) in two stages of pre and post of test. Data were analyzed using SPSS software. According to the findings of this research, the average of girls’ age was 22.41± 3.22 and 55.3% of them, had college education and 53.9% of them were housewives. The mean score of awareness about reproductive health before the education, was 12.81±33.3 that increased to the 17.81±. 2.587after training and this difference was statistically significant (p= 0.000).As well as level of satisfaction of participants...
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Posted by admin on Dec 31, 2016 in |
Background: Antimicrobials are used for bacterial infections & has a great benefits in health related problems of human life. The main objectives of medicinal chemistry is synthesising and producing newer molecules having a valuable significant therapeutic action. Quinolones has a considerable scientific and clinical interest since their discovery. Objective: Quinolones class of drugs are useful in the treatment of serious bacterial infections thus keeping in view a potential approach is made for synthesising & characterizing of newer quinolone derivatives for their biological activity. Method: Quinolone ester was synthesised from Gould-Jacob reaction by using substituted aniline & diethylethoxymethelene malonate (EMME) Results: Solubility of all synthesised compounds were checked in various solvents & were characterized by FT-IR, 1H-NMR. Conclusion: The result of the present study thus demonstrates the anti-microbial activity against gram positive (Bacillus subtilis) & gram negative (Escherichia coli)...
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Posted by admin on Dec 31, 2016 in |
Increasing use of bioinformatics made very easy to researchers in biological and drug discovery field. Bioinformatics is involved at each and every step of drug discovery to drug development. The first step of the drug discovery is a question about disease and the treatment by drugs and whenever term drug comes, means something has to be given and the second question arises the given compound is drugable or not. To check any drugable compound the compound has to be cleared by the ADME studies and the main sensitive parameter blood brain barrier. Bioinformatics made it easy without use of model organism and waste of time. In this study we aimed to predict the blood brain barrier parameters on 87 drugs about their drug...
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Posted by admin on Dec 31, 2016 in |
Diclofenac Sodium, being NSAID, its oral administration restricted due to its inherent problems. Hence in the present study, attempt has been made to design oral sustained release once daily matrix tablets of Diclofenac Sodium using combination of hydroxyl propyl methyl cellulose (HPMC) & PEG 6000 and to study the effect of various process and formulation variables like polymer properties and polymer viscosity on in-vitro release of drug. Sustained release tablets of Diclofenac sodium were prepared using different proportion of HPMC 4000 cps and PEG 6000 (F1, F2, F3……..F6). The physical properties of prepared tablets like hardness, friability, weight variation, thickness and drug content were studied and were found to be within the acceptable limits. In-vitro release studies were performed in Simulated Gastric Fluid (SGF) pH-1.2 for two hours and Simulated Intestinal Fluid (SIF) pH-6.8 for subsequent 10 hours by USP-I dissolution apparatus, in 900 ml at 37.5±0.5oC (stirring speed was 70 rpm). As amount of HPMC was increased from 5% to 30%, released rate was decreased. However, no appreciable...
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