Posted by admin on Feb 28, 2017 in |
The study objectives were to develop a unique expandable integrated floating film to be filled in capsule dosage form, which combines hydrophilic and hydrophobic polymers. The developed film was totally free from the concept of gas generating system or the low-density system, which floats merely due to Archimedes principle. A 32 full factorial design was used in the study with HPMC K100M (X1) and ethylcellulose cp10 (X2) as independent variables and time required for dissolution of drug and swelling as dependent variables. FTIR and DSC studies were carried out to investigate any drug excipient interaction. The XRD studies of formulation showed decreased crystallinity of the drug levofloxacin. Steady slow gel formation and the higher concentration of ethylcellulose, resulted in sustained drug release. The hydrophilic polymer readily expands the polymeric network within two hours. The predicted value of 90.419 and the actual drug release from the polymeric film were closely related to each...
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Posted by admin on Feb 28, 2017 in |
Aim of this study was to identify and characterise the bioactive principles from the latex of Calotropis procera which could influence cellular and humoral aspects of immune system which may influence immune disorders. Calotropis procera R.Br. (Asclepiadaceae), commonly known as milk weed or swallow-wort, is a medicinal plant widely used as a folk medicine in India. It exhibits a wide spectrum of pharmacological activities shown by various research activities till date like anti microbial, anticancer wound healing. After successive extraction of dried latex ethyl acetate extract of latex was subjected to bioassay-guided fractionation. The two fractions obtained (EA I and II) were tested for immunomodulatory activity using delayed type hypersensitivity and humoral antibody titre by antigenic sheep RBCs. The active molecule was isolated, based upon bioassay guided fractionation, and identified as β-sitosterol on spectral evidence. Only the fraction (EA I) containing β- Sitosterol showed promising humoral and cellular activity with Primary HA titre value 201.29 ± 2.35 and secondary HA titre value 296.51 ± 1.45. β- Sitosterol, a pentacyclic...
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Posted by admin on Feb 28, 2017 in |
Practising complementary and alternative medicinal therapy has become a boom worldwide. There is a dearth in communication between doctors and the patients regarding concomitant use of complementary medicines like ayurvedic churnas and other drugs of natural origin with allopathic drugs. This usage might magnify or oppose the effect of synthetic drug leading to interactions. Use of herbals along with allopathic treatment is inevitable in treatment of chronic diabetes which might lead to drug interaction. The present study was undertaken to evaluate pharmacokinetic interaction between herb Gymnema sylvestre and allopathic drug Sitagliptin Phosphate in streptozotocin and high fat diet-induced type II diabetes mellitus in rat model. Female Sprague Dawley rats were grouped into following groups. Group 1: Vehicle Control (VC), Group 2: Disease Control (DC), Group 3: Sitagliptin Phosphate (STG) (20 mg/kg), Group 4: Gymnema sylvestre (GYM) (400 mg/kg), Group 5: Sitagliptin Phosphate (20 mg/kg) and Gymnema sylvestre (400 mg/kg) (STG + GYM). After giving proper treatment to the rats, blood samples were withdrawn from retro-orbital plexus at 0th, 2nd,...
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Posted by admin on Feb 28, 2017 in |
Diphenhydramine hydrochloride (DPH) is an antihistamine used topically to relieve skin itching and, at higher doses, DPH also has the capability to induce local skin anesthesia. The present study investigates the possibility to deliver DPH via iontophoresis using a stainless steel electrode. In-vitro iontophoresis was performed using 1% (w/v) DPH dissolved in glycerin (100%), deionized (DI) water (100%) and a mixture of both (50:50) through porcine ear skin and Franz cell assembly. The applied electrical current was 0, 100, 200, and 300 µA/cm2 for 60 min. Of the solvents tested, the 100% glycerin provided a consistent increase in DPH skin concentrations with current density and no skin damage. Therefore, the 100% glycerin was selected for in-vivo iontophoresis in a rabbit model at the same three current densities for 60 min. DPH skin concentrations were measured in skin via microdialysis for 240 min. Plasma to skin distribution of DPH was studied following short IV-infusions of 6, 8 and 10 mg/Kg in rabbits. Skin and plasma samples were collected for 420...
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Posted by admin on Feb 28, 2017 in |
The objective of this study was to design and develop a skin lighting cream for improved skin whitening using herbal extracts from Glycyrrhiza glabra (Licorice) root and Vateria indica bark. The carrier cream base was developed by emulsion technique to deliver skin whitening property by holding the natural herbal actives such as G. glabra root extract and V. Indica bark extract as well as physical sun protecting agents such as titanium dioxide for the skin whitening properties. The emulsion cream was designed and optimized to deliver the skin lighting property by the combination of G. glabra root extract and V. Indica bark extract. This unique composition helps to provide the melanin inhibition effect through cellular melanin inhibition pathway. The optimized emulsion cream formula was evaluated as per ICH stability guidelines (real time, 30°C and 65% Relative Humidity (RH) and accelerated, 45°C and 75% RH) to ensure emulsion cream stability and shelf life of the product. The optimized and stabilized formula flow behaviours were determined by various rheological studies such...
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