Posted by admin on Nov 30, 2016 in |
Mesua ferrea Linn. is a flowering tree found in Western Ghats of India, belonging to family Clusiaceae. Extraction process was standardized by cold maceration method with n-hexane. Essential oil extracted from different parts of the flower was also subjected to GC/MS and headspace analysis. The GC/MS analysis of essential oils from whole flowers of M. ferrea shows following components. Alpha-Copaene (13.52%), Trans-Alpha-Bergamotene (09.12%), Benzoate Geranyle-1 (09.82%), and Dioctyl Phtalate (20.21%), where as essential oil extracted from the petals of M. ferrea contained Alpha-Copaene (22.72%), Trans-Alpha-Bergamotene (17.42%), and Dicotyl Terephthalate (13.90%). The major components identified in stamens of the flowers by headspace technology were Alpha Copaene (28.49%), Beta caryophyllene (5.98%), Trans-Beta-Farnesene (9.24%), Trans-Alpha-Bargamotene (30.91%), and Alpha Bisabolene (5.15%) where as in petal of the flowers were Alpha Copaene (27.40%), Beta Selinene (5.18%), Trans-Alpha-Bargamotene (31.56%), Alpha Bisabolene (6.06%). The essential oils extracted from M. ferrea were also subjected to olfactory evaluation and was incorporated in cosmetic products (Hair oil, Massage oil and Body...
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Posted by admin on Nov 30, 2016 in |
Cancer is an uncontrollable incurable disease with abnormal growth and proliferation of cells. Thyroid cancer is caused due to the thyroid hormone effects on growth, development and homeostasis in mammals. Thyroid cancer is the most common endocrine malignancy. Thyroid hormone is encoded by two types of thyroid receptors that are TRα and TRβ. TRα is functionally divided in two types TRα1 and TRα2. TRα1 is expressed first during fetal development and is widely expressed in adult tissues. Over-expression of TRα1 has shown its ability to trigger hyper-proliferation and to accelerate the tumeorigenic process in developing intestinal cancer. The novelty of our approach is to demonstrate the inhibitory activity of a plant extract compound against TRα1 using In-silico methods. Andrographis paniculata plant leaf is extracted with Methanol and three compounds were identified from GC-MS analysis. The 3D crystal structure of the thyroid cancer for Thyroid hormone receptor alpha1 (ID: 1NAV) were retrieved from the Protein Data Bank (PDB) and was used for carrying out the molecular docking calculation. The result shows...
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Posted by admin on Nov 4, 2016 in |
Stress is part and parcel of our life and stress management is gaining importance day by day. Traditional mantras are reported to be very effective for and safe methods. Hence the traditional knowledge of mantras should be practiced, preserved and propagated. Om Namah Shivaya is a most potent and popular mantra, which is at the heart of the Vedas and Tantra. The present study was aimed to observe beneficial effects of OM Namah Shivaya chanting for stress management in elderly women with hypertension. The study was conducted at Sattva Cultural Space and Research Centre, Angamaly, Kerala. 8 elderly women aged 55-65 years with stage 2 hypertension were recruited in the present study after obtaining written informed consent. After recording baseline values, participants underwent practice sessions for 3 days under supervision of yoga teacher from the centre. After the practice sessions, participants chanted Om Namah Shivaya for 108 times by using japamala with 108 beds at 6;30 in the morning for 40 days under supervision of yoga teacher. Participants were...
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Posted by admin on Oct 31, 2016 in |
In chronic alcoholics, continuous heavy drinking leads to progression of alcoholic liver disease (ALD) from alcoholic fatty liver, hepatitis to cirrhosis. Strict abstinence from alcohol has its own limitations and there is paucity of promising drugs available to treat ALD. Malotilate showed promising hepatocyte regenerating capacity and ability to prevent such damage. Aims: The objective of this study was to evaluate curative effect of malotilate on ALD in rats. Methods: The study was done using Sprague Dawley rats. 5 groups were treated as: 1. Control: ethanol 40% v/v (orally 1ml / 100 g / d), 2. Vehicle control: Methyl Cellulose and 3, 4, 5: malotilate, three doses 25 (Low), 50 (Moderate), 100 (High) mg /kg / d orally, respectively. In all groups: ethanol was given initially for 21 days. Then vehicle or malotilate was administered for next 21 days. The liver damage was assessed bio-chemically on day-1, day-22, day-43 by measuring serum AST, ALT, ALP, GGT, total bilirubin, direct bilirubin, total protein, albumin and prothrombin time. The histo-pathological assessment...
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Posted by admin on Oct 31, 2016 in |
Pharmacokinetic modeling is the representation of the logarithmic mathematical equations in order to measure the physiologic response of the body to the drug. Absorption, distribution, metabolism and excretion follow drug kinetic principles according to specific reaction mechanisms in which concentration of the drug may either be dependent or independent of drug-body interactions. Michaelis-Menten equation exhibits association between drug concentration and its mass transfer through a kinetics transport mechanism, a principle also known as Fick’s Law of Diffusion. Reaction orders are the sum of the powers of drug concentrations being raised to a certain degree that follows a certain pattern of drug kinetics according to rate laws being established. Reactions between the drug and the body usually follows first and second order rate. First order rate of reaction can be described as drug concentration dependent, whereas, zero order reaction rate can be explained as drug concentration independent. This paper aims to describe the derivation of pharmacokinetic principles acting in multi-compartment model as the drug enters and exits the body using...
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