Posted by admin on Dec 31, 2016 in |
Background: India is highest tuberculosis (TB) burden country accounting for approximately 20% of global TB burden. To tackle this problem, Revised National Tuberculosis Control Programme (RNTCP) based on the DOTS (Directly Observed Treatment Short course) strategy has been made available in the entire country by March 2006. Present study describes the achievements under RNTCP in terms of treatment outcomes, smear conversion rate and evaluation of risk factors for unsuccessful treatment outcome at district tuberculosis centre. Objectives: Treatment outcome of tuberculosis (TB) patients on DOTS (category 1& 2) and evaluation of predictors for unsuccessful outcome. Methodology: A record- based retrospective study; analysis of cases registered for treatment for Cat -1 & 2 at district tuberculosis centre during 2013 & 2014 was done. Data regarding demographic profile, TB type & categories, investigation, treatment outcome and co morbidity were recorded. Data were analyzed and appropriate statistical test was done using Epi info 7, CDC. Result: Out of 1340 registered cases, 1081 (80.67%) were of cat1 and 259 (19.33%) were of cat-2 TB. ...
Read More
Posted by admin on Dec 31, 2016 in |
Simultaneous estimation method for Norfloxacin and Tinidazole in tablet dosage form had been developed by RP- HPLC. Both the drugs come under the category of antimicrobials and prescribed frequently in combination. The developed method is a gradient method which gives retention time of Norfloxacin and Tinidazole as 3.8min and 4.8min respectively. The separation was carried out on Supelco C18 (25cm × 4.6mm, 5µ) column using 0.05M phosphate buffer (pH 3 adjusted with ortho- phosphoric acid) and acetonitrile as a mobile phase. The flow rate was 0.8mL/min and wavelength used was 300nm. The method was validated as per ICH guideline and found to be linear between the range of 1- 6µg/mL for Norfloxacin and 1.5- 9µg/mL for Tinidazole. The developed method was found to be rapid, accurate and reproducible and therefore can be applied for simultaneous estimation of both the drugs as API or tablet dosage form...
Read More
Posted by admin on Dec 31, 2016 in |
Essential oils extracted from two Algerian endemic plants Lavandula antineae and Thymus algeriensis were analyzed by the GC, the results showed the presence of a large amount of oxygenated sesquiterpenes in both species. Total phenolics and flavonoids content were determined according to the Folin-Ciocalteu method and the aluminum trichloride method, the antioxidant activities of two types of extracts (ethyl acetate and n-butanol) from the plants were tested with the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The rates of total phenolics and flavonoids present in L. antineae equal to 2,013± 0,009 mg GAE / g of dry plant and 0.587± 0,003 mg QER / g of dry plant material respectively. Thymus algeriensis has presented values of phenolics and flavonoids equal to1.337± 0,001 mg GAE / g and 0.339± 0,001 mg QER / g of the dry plant. The ethyl acetate extract of L. antineae have presented the higher EC50 value...
Read More
Posted by admin on Dec 31, 2016 in |
Sunscreens aid the body’s natural defense mechanisms to protect against harmful UV radiation from the sun. The present study involves the formulation of sunscreen cream with herbal active ingredients and evaluation for its effectiveness. Naturally occurring traditional substances are gradually replacing synthetic counterparts due to their effectiveness and absence of adverse effects. The herbal drugs selected for the study were roots of Glycyrrhiza glabra Linn. (Yashtimadhu), Hemidesmus indicus R.Br. (Anantmul) and heartwood of Santalum album Linn. (Chandana). Creams were prepared with each individual herb and combination of all three herbs with varying concentration of herbal extracts. The evaluation included determination of Sun Protection Factor for all the formulated creams. The SPF was calculated using the spectrophotometric method and then applying the Mansur equation. The results of the study indicated that the 25% combination cream showed maximum sun screeening...
Read More
Posted by admin on Dec 31, 2016 in |
Aim: Labetalol is useful in severe hypertension (HT) in pregnancy; however, there was a need to define its role in mild HT in pregnancy. The present study was done to evaluate efficacy of labetalol in mild HT in pregnancy, compare it with that of methyldopa, and compare the tolerability of methyldopa and labetalol in patients. Methods: A prospective drug comparative study was conducted for one year in 60 mild hypertensive pregnant women, with gestational age of ≥20 weeks, receiving either labetalol or methyldopa. The primary endpoint was control of blood pressure (BP). The parameters recorded for comparison were time and dose to control BP, dose escalation, urine albumin level, adverse effects, and pregnancy outcomes. Results: Both the drugs produced significant reduction in BP in the patients (p<0.001). The patients in both groups showed significant reduction of urine albumin. Same number of patients in both groups required dose escalation. Time to control BP was less in the patients receiving methyldopa than those receiving labetalol; however, the patients receiving labetalol reported...
Read More
