Posted by admin on Nov 30, 2016 in |
Allium sativum (A. sativum), commonly known as garlic, is a species in the onion genus, Allium. The hypolipidemic activity of A. Sativum (Family: Amaryllidaceae) extract have been studied in alloxan-induced diabetic rats. In this model oral administration of extract (500mg/kg bw., p.o.) for 15 days in diabetic-dyslipidemic rats exerted significant lipid lowering effect as assessed by the reversal of serum levels of total cholesterol, phospholipids, triglyceride, free fatty acids, protein and lipid peroxide. The decrease of lipids and apoprotein levels of Very Low Density Lipoprotein and Low Density Lipoprotein were followed by stimulation of plasma post-heparin lipolytic activity as well as lecithin cholesterol acyltransferase, hepatic superoxide dismutase, catalase, triglyceride lipase and lipoprotein lipase activities with increase in reduced glutathione. Lipid and apoprotein level of High Density Lipoprotein were also recovered partially on treatment with A. sativum extract. The results of the present study demonstrated antidyslipidemic and antioxidant activities in A. sativum extract which could be used in prevention of diabetic dyslipidemia and related complications. The hypolipidemic activity of A....
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Posted by admin on Nov 30, 2016 in |
The persent study was designed to investigate the anxiolytic activity of ethanolic extract of Leptadenia reticulata plant. It is a folk medicine traditionally used in treatment of eye diseases, seminal debility, general weekness, cough, fever, asthma, sore throat and gonorrhea. The anxiolytic activity was evaluated by Elevated plus maze Test, Light-Dark Test, Hole-board Test and Social-intraction Test models by using Wistar albino rats. The extract at oral dose 200mg/kg and 400mg/kg at body weight significantly increased time spend and no of entries in open arms in Elevated plus maze test and time spend in light area in light-dark test and no of head dipping in hole board test and also inceased social interaction time in social interaction test as compard to control animals. The effect was compared to the Diazepam (2mg/kg i.p.) as standard anxiolytic drug. The result of study indicate that the Leptadenia reticulata plant have potant anxiolytic...
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Posted by admin on Nov 30, 2016 in |
Blepharis molluginifolia (Acanthaceae), is a threatened medicinal herb. The methanolic flower extract of Blepharis molluginifolia was subjected to Silica Gel Column Chromatography for purification of bioactive compounds and structure elucidation of active compounds were studied. DPPH and antimicrobial activities of two isolated compounds were studied. From the analysed data, the compounds identified were 5,7-Dihydroxy-3-(4-methoxyphenyl)chromen-4-one (BiochaninA) C16H12O5 and 5,7-Dihydroxy-3-(4-hydroxyphenyl) chromen-4-one (Genistein) C15H10O5. These compounds are first time reported in this plant. Another fraction GF1 was subjected to GCMS analysis and obtained 12 compounds (aminoacid, gamma lactone, sugars and fatty acids).As GCMS profile contained majority of sugars antiglycation was done against arbutrin and found >70% inhibition. The present investigation revealed that the methanolic flower extract contained phytoestrogens like Biochanin A and Genistein, the rare aminoacid pyroglutamic acid, gamma lactones, sugars and fatty...
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Posted by admin on Nov 30, 2016 in |
Mesua ferrea Linn. is a flowering tree found in Western Ghats of India, belonging to family Clusiaceae. Extraction process was standardized by cold maceration method with n-hexane. Essential oil extracted from different parts of the flower was also subjected to GC/MS and headspace analysis. The GC/MS analysis of essential oils from whole flowers of M. ferrea shows following components. Alpha-Copaene (13.52%), Trans-Alpha-Bergamotene (09.12%), Benzoate Geranyle-1 (09.82%), and Dioctyl Phtalate (20.21%), where as essential oil extracted from the petals of M. ferrea contained Alpha-Copaene (22.72%), Trans-Alpha-Bergamotene (17.42%), and Dicotyl Terephthalate (13.90%). The major components identified in stamens of the flowers by headspace technology were Alpha Copaene (28.49%), Beta caryophyllene (5.98%), Trans-Beta-Farnesene (9.24%), Trans-Alpha-Bargamotene (30.91%), and Alpha Bisabolene (5.15%) where as in petal of the flowers were Alpha Copaene (27.40%), Beta Selinene (5.18%), Trans-Alpha-Bargamotene (31.56%), Alpha Bisabolene (6.06%). The essential oils extracted from M. ferrea were also subjected to olfactory evaluation and was incorporated in cosmetic products (Hair oil, Massage oil and Body...
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Posted by admin on Nov 30, 2016 in |
Cancer is an uncontrollable incurable disease with abnormal growth and proliferation of cells. Thyroid cancer is caused due to the thyroid hormone effects on growth, development and homeostasis in mammals. Thyroid cancer is the most common endocrine malignancy. Thyroid hormone is encoded by two types of thyroid receptors that are TRα and TRβ. TRα is functionally divided in two types TRα1 and TRα2. TRα1 is expressed first during fetal development and is widely expressed in adult tissues. Over-expression of TRα1 has shown its ability to trigger hyper-proliferation and to accelerate the tumeorigenic process in developing intestinal cancer. The novelty of our approach is to demonstrate the inhibitory activity of a plant extract compound against TRα1 using In-silico methods. Andrographis paniculata plant leaf is extracted with Methanol and three compounds were identified from GC-MS analysis. The 3D crystal structure of the thyroid cancer for Thyroid hormone receptor alpha1 (ID: 1NAV) were retrieved from the Protein Data Bank (PDB) and was used for carrying out the molecular docking calculation. The result shows...
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