Posted by admin on Jul 31, 2016 in |
Background: Pediatrics pose a unique set of risks of medication errors, predominantly because of the need to make dosage calculations, which are individually based on the patient’s weight, age or body surface area (BSA), and their condition. This increases the likelihood of errors, particularly dosing errors. In particular; preventing dosing errors is an important part of ensuring safe and quality patient care in the pediatric population. To evaluate appropriateness and accuracy of the prescribed drug dose using BSA as a parameter in pediatric patients. Methods: The present study was cross sectional, observational, and prospective one, conducted on an outpatient basis in pediatric patients. A total of 500 prescriptions were randomly collected and used to analyze prescribed dose. Calculation of standard dose according to BSA of individual of each drug was done by using formula: Individual dose = BSA (m2)/1.7 × average adult dose and compared with the prescribed dose of that particular drug. The BSA of an individual can be calculated from Dubois Raymond’s formula. Results: The 500 prescriptions...
Read More
Posted by admin on Jul 31, 2016 in |
Hyperlipidemia is the greatest risk factor of coronary heart disease, currently available hypolipidemic drugs have been associated with number of side effects. Literature claims that flavonoids are able to reduce hyperlipidemia. Based on high flavonoids content in herbal plants, Nymphaea alba (NA) family Nymphaeaceae were selected and the present study focus on the antihyperlipidemic activity of methanol extract of leaves of NA against triton induced hyperlipididemia in rats. NA was administered at a dose of 100mg &200mg /kg (p.o) to triton induced hyperlipidemic rats. Fenofibrate was used as a reference standard. The statistical analyses were carried out using one way ANOVA followed by dunnets multiple comparisions test. NA shows a significant decrease in the levels of serum cholesterol, phospholipids, triglyceride, LDL, VLDL and significant increase in the level of serum HDL at the dose of 100 & 200mg/kg (p.o) against trition induced hyperlipidemic in rats. Methanol extracts decreased serum level of total cholesterol by 74.25%. On the other hand aqueous extract of NA increased the serum HDL cholesterol level...
Read More
Posted by admin on Jul 31, 2016 in |
Objective– To rationalize the Macroscopical and Microscopical study, Phytochemical analysis, TLC and HPTLC fingerprinting of Bauhinia purpurea Linn. Leaves. Methods– The crude ethanolic extract of leaves of Bauhinia purpurea Linn. was using the macroscopical characters (size, shape, colour, odour, taste, surface, texture, venation, margin, base, and petiole) powder microscopical study, the powder was stained with phloroglucinol and concentrated HCl to study the lignified cells, lignified parenchyma, trichomes, fibres, xylem vessels, mesophyll, palisade cells and stomata, etc, Preliminary phytochemical tests (Glycosides, Saponins, Tannins, Flavonoids etc.) and Preliminary photochemical investigation of TLC and HPTLC. Results: An attempt has been made to highlight this folk herbal medicine through present study which will assist in the identification of fresh as well as dried crude samples of leaves phytochemically, macroscopically and microscopically. TLC and HPTLC fingerprint profiling were carried out and the salient qualitative and quantitative parameters are reported. Conclusion: The present study will provide referential information for correct identification and help in checking adulteration in market sample used in the preparation of various...
Read More
Posted by admin on Jul 31, 2016 in |
Urinary tract infections causing bacteria play an important role in expression and spread of drug resistance among bacteria in the hospitals and in community. Because of rapid increase in antibiotic resistance, alternative antimicrobial agents are needed to be developed and employed to control multi-drug resistant bacteria. The present study focuses on antibacterial activity of Green and Black tea (Camellia sinensis) extracts against the virulent uropathogens. Twelve bacterial isolates from urinary tract infections were studied for their ability to produce virulence phenotypes like hemolysin, biofilms, gelatinases, hydrophobic nature and penicillinases. Antibacterial susceptibility testing was done. Out of the total isolates tested 67% of E.coli and 60% of Klebsiella spp were multi drug resistant Penicillinase production as tested by filter paper iodometric method and biofilm production on Congo red plates were the virulence features exhibited by maximum number of E.coli and Klebsiella Spp. Among the aqueous, methanol and ethanol extracts tested for antibacterial activity, methanol extracts showed maximum dimeter of zone of inhibition. Minimum inhibitory concentration for ethanol and aqueous extracts was 0.8mg /ml whereas that for...
Read More
Posted by admin on Jul 31, 2016 in |
The aim of my present study is to Develop and Evaluate Microemulsion for topical application of Aceclofenac by using oleic acid at different ratios for the treatment of pain. Microemulsion was prepared by water trituration method using oleic acid as oil phase, tween-80 as surfactant and polyethylen glycol-400 as co-surfactant. Different oils, surfactants and co-surfactants were screened to select ideal components of microemulsions with good solubility and excellent skin penetration of Aceclofenac. The solubility of Aceclofenac was highest in oleic acid followed by olive oil, and isopropyl myristate, isopropyl palmitate. Microemulsion-3 (ME-3) was exhibited 98.54±0.26% higher drug content then other formulations. Among all formulations, the highest permeation flux of µg/cm2/hour was observed in of formulation...
Read More
