Posted by admin on Oct 31, 2016 in |
Diabetes is a rapid gaining status of potential epidemic in India with more than 62 million diabetic individuals currently diagnosed with the disease. Drug utilization studies are important for the optimization of drug therapy and have received a great attention in recent years. The study of drug utilization or prescribing patterns is a component of medical audit, which seeks monitoring, evaluation and necessary modifications in the prescribing practices to achieve rational and cost effective pharmacotherapy. These studies serves as a tool of investigation for clinical pharmacology and as source of suggestive information for epidemiology. The present study aimed to evaluate the drug utilization pattern of standard antidiabetic drugs in a medicine outpatient clinic of a tertiary care teaching hospital. It’s a retrospective observational epidemiological study undertaken for a period of 8 months in outpatient unit of a tertiary care Hospital, Erode. The study enrolled 175 patient prescriptions. A total of 175 patients had co-morbid conditions along with diabetes. Commonly seen co-morbid condition in the study was hypertension. The study...
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Posted by admin on Oct 31, 2016 in |
Herbal plants produce a diverse range of bioactive molecules, making them a rich source of different types of medicines. Thus, a proper scientific evidence or assessment has become the criteria for acceptance of herbal health claims. As such developing a polyherbal formulation will definitely produce synergistic effect as needed comparable to standard drugs that are available in market all over the world. The polyherbal formulation, which has a combination of medicinal herbs such as Allium sativum, Trigonella foenum-graecum, Linum usitatissimum was tested for its antioxidant activity, total phenolic and alkaloid contents in-vitro. The purpose of the present study was to investigate the in-vitro antioxidant, total phenolic and alkaloid content of polyherbal formulation and its application for treating life threatening diseases such as cancer, cardiac diseases, diabetes mellitus. In this paper we report the results of such studies in order to orient future investigations towards the finding of new, potent, safe and easily available food...
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Posted by admin on Oct 31, 2016 in |
The objective of the present investigation is to prepare and evaluate the sustained release matrix tablets of Diltiazem HCl using a natural polymer Gum kondagogu. Diltiazem HCl was formulated as sustained release matrix tablet formulations with natural polymer by employing pharmaceutically acceptable electrolytes. Electrolytes such as Sodium carbonate, Magnesium carbonate and Calcium carbonate were used at specific concentration, in various formulations. Total twelve formulations (DG1-DG12) were prepared by using different proportions of drug and Gum kondagogu (1:0.5, 1:1, 1:1.5, 1:2) with the aid of granulating fluids such as distilled water, ethanol and isopropyl alcohol. From 12 formulations DG3, DG7 and DG11 were optimized based on results from physicochemical evaluation and drug release studies. These formulations have composition of 1:1.5 ratio of drug and Gum kondagogu & they have shown more than 95% drug release at 12 hours. Hence based on studies, formulation DG10 with drug and polymer with 1:1 ratio was selected for further studies by employing electrolytes in different concentrations. These electrolytes were employed to examine matrix swelling...
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Posted by admin on Oct 31, 2016 in |
Streptozotocin (STZ) induced neurotoxicity causes development of diabetic neuropathy in rodent models and oxidative stress is the main culprit in development of diabetic neuropathy. In the present study we aimed to evaluate the neuroprotective and antioxidant role of Pregabalin in STZ induced neurotoxicity. After 8 weeks, STZ induced diabetic rats showed sciatic nerve damage which was evident from hyperalgesia, allodynia, motor deficits and Transmission Electron Microscopic studies of sciatic nerves. Pregabalin treatment at a daily dose of 15 mg/kg for 7 weeks ameliorated hyperalgesia, allodynia, motor deficits and prevented the structural abnormalities in sciatic nerves of diabetic rats. STZ neurotoxicity reduced antioxidant enzyme levels in sciatic nerves. Pregabalin treatment significantly ameliorated the decrease in antioxidant defence in diabetic rats. These results demonstrated neuroprotective effect of Pregabalin, which is mediated through attenuation of oxidative stress. The antioxidant mediated neuroprotective role along with its analgesic activity can prove it as a better option in prevention and treatment of Diabetic...
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Posted by admin on Oct 5, 2016 in |
The challenges to ensure proper preparation, storage, preservation and distribution of drugs are enormous. Very often, this results in the production and distribution of contaminated drugs. The study, therefore aimed to evaluate the prevalence of contaminating microorganisms in anti-malarial drugs sold in Calabar, Cross River State, Nigeria. This was carried out using standard microbiological procedures which included total aerobic bacterial plate count, isolation and characterization of microbial contaminants and physical parameters analysis. It is evidence from the results that out of a total of 10 samples, only one sample was not contaminated by bacteria but for fungi, all the drugs sampled were contaminated. Bacillus subtilis was found to be the most prominent bacterial isolates with the frequency of occurrence of five (5) and 33.5%, followed by P. aeruginosa and S. aureus with the same frequency of three (3) and 20.0%, Lactobacillus sp. had frequency of two (2) and 13.3%, and Sporolactobacillus had frequency of one (1) and 6.6% while only one of the anti-malarial drugs had no contamination, that...
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