Posted by admin on Jul 31, 2016 in |
Evidence implicates hyperglycemia induced oxidative stress as a key factor in the pathogenesis of both microvascular and macrovascular complications in the body. Our main objective behind this study was to explore the beneficial effect of Caesalpinia bonducella seed kernel extract on Streptozotocin-induced hyperglycaemia and oxidative damage in rats. Rats were made hyperglycemic by single intravenous injection of Streptozotocin 40mg/kg of body weight. Hyperglycemic rats treated with extract in three different doses of 200, 400 and 600 mg/kg of body weight orally for 21 days shows a significant decrease in blood glucose, HbA1c, free amino groups whereas an increase in serum insulin level, liver glycogen contents with a significant improvement in glucose tolerance. Furthermore, above extract supplementation significantly decreases the pancreatic thiobarbituric acid-reactive substances levels along with an increase in superoxide dismutase, catalase and glutathione contents in pancreatic tissues in treatment groups when compared with control hyperglycemic rats. Treatment with above extract has lessened the severities of degenerative changes in pancreas and also in the liver tissues as compared to...
Read More
Posted by admin on Jul 31, 2016 in |
Aim: To rationalize the macroscopial, anatomical and physico- chemical studies on leaves of Ficus benghalensis (Maraceae). Materials & methods: The crude ethanolic extract of leaves of Ficus benghalensis (Maraceae) was using Physico-chemical parameters, and Preliminary photochemical investigation (TLC, HPTLC, & Column Chrmatography). Results and conclusion: An attempt had been made to highlight this folk herbal medicine through dried crude samples anatomically and physico chemically. TLC fingerprint and HPTLC were carried out and the salient macroscopial qualitative and quantitative parameters were reported. These studies will provide referential information for correct information and help in checking adulteration in market sample...
Read More
Posted by admin on Jul 31, 2016 in |
Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer’s disease. The present study was designed to investigate the neuroprotective effects of isorhamnetin (IRN) against amyloid beta 25-35 (Aβ 25-35)-induced memory impairment and oxidative damage in rats. Memory task was assessed using Y-arm maze and it revealed the impairment in spatial memory. The IRN treated rats showed improvement in memory task. Aβ 25-35 induced animals also exhibited increase in hydrogen peroxide (H2O2), Monoamine oxidase activity (MAO) and decrease in choline acetyltransferase (ChAT) activity. It also enhanced the expression of inducible nitric oxide synthase (iNOS) and proinflammatory cytokine, IL-β whereas all these abnormalities were reduced significantly in IRN treated rats showing the neuroprotective effect of IRN against Aβ 25-35 induced Alzheimer’s disease (AD). Thus, IRN may be a potential therapeutic agent for Alzheimer’s...
Read More
Posted by admin on Jul 31, 2016 in |
A new physiologically active compound E-2-((2-amino pyridine-3-yl) methylene amino)ethane thiol derived from the condensation of Cysteamine and 2-amino Pyridine 3-Carbaldehyde was synthesized and characterized by spectral techniques like IR, UV-Vis,1H- NMR, TG-DTA, ESR, CHN analyses. The complexes were further screened for their biological activity at Nishka labs and Nickel and Cobalt complexes were found to be potent antibacterial agents. From the above analysis it was found that the ligand behaves as a neutral ligand with N: N: S:N:N donor sequence for octahedral...
Read More
Posted by admin on Jul 31, 2016 in |
The chemotherapy prescribing errors (PEs) can lead to tragic consequences for the oncology patients. This cross-sectional observational study aims to predict the incidence of prescribing errors involving chemotherapeutic agents, and review their severity, through examining a random sample of 500 cancer patients at the out-patient chemotherapy unit of Ain Shams University Hospital, Cairo, Egypt; from March 2014 till August 2014. British Columbia Cancer Agency (BCCA) data base was used as a reference to identify the PEs. Prescription errors were classified according to their incidence and severity; in addition the relation between the risk factors and the observed PEs was studied. The study revealed that all the cases contained at least one error, the most common error incidence was the unspecified tumor staging in the protocol template (n=341, 68%), followed by dose error incidence (n=317, 66%). The risk factors predicting the prescribing medication errors were identified as: the protocol type, the tumor type, the toxicity type of the antineoplastic regimen, and others. Therefore identification of risk factors leading to prescribing...
Read More
