Posted by admin on Nov 30, 2016 in |
The aim of the research work was to develop and optimize fast dissolving tablets of Promethazine Thecolate by direct compression using effervescent technology. For the investigation, purpose a 32 full factorial design was used to know the joint influence of two formulation variables, Crospovidone and Citric acid. The formulated tablets were evaluated for its percent friability and their disintegration time. The results of multiple linear regression analysis revealed that for obtaining a rapidly disintegrating dosage form, tablets should be prepared using an optimum concentration of sodium starch glycolate and a crospovidone. A contour plot was also presented to graphically represent the effect of the independent variables on the disintegration time 30 s and percent friability 0.5 %. A checkpoint batch was also prepared to prove the validity of the evolved mathematical model. The optimized tablet should be prepared with an optimum amount of Sodium starch Glycolate (2.75 mg), and Crospovidone (2.72 mg) which disintegrated in the 30 seconds, with friability of 0.5% and of drug release within 5 min....
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Posted by admin on Nov 30, 2016 in |
Vitex negundo is an Indian medicinal plant used to cure several diseases such as asthama, fever, headache, cancer and many other diseases. This study aims to determine the antioxidant potential and anti-proliferative activity of Vitex negundo methanolic leaf extract. Isolation of bioactive compounds involved liquid-liquid extraction of methanolic leaf extract by petroleum ether and chloroform. The total antioxidant potential of the extracts was determined using phosphomolybdenum, 2,2-Diphenyl-1-picrylhydrazyl (DPPH), Ferric oxide reducing power (FRAP) and Nitric Oxide methods. It was observed that the crude and chloroform extracts had good antioxidant activity. The antileukemic activity of the chloroform extract was tested on HEL92.1.7 and Jurkat cell lines (Acute lymphoblastic leukemia derived) by cytotoxicity assay (MTT). The plant extracts exhibited poor cytotoxicity against the erythroid cell lines but showed good cytoxicity on Acute lymphoblastic leukemia cells. This study shows that the chloroform fraction of V negundo leaf has both antioxidant and antileukemic...
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Posted by admin on Nov 30, 2016 in |
Although many studies have demonstrated the importance of the apoB/apoA-1 ratio as a risk marker of atherogenicity, less is known about apoB/apoA-1 ratio in predicting and the severity of coronary artery disease (CAD) in T2DM. Our study aimed to assess possible associations between apoB/apoA-1 ratio levels and the severity of coronary artery diseases in patients with type 2 diabetes mellitus (T2DM). Plasma levels of lipidic profile components, apolipoproteins and the apoB/apoA-1 ratio were determined in 148 CAD patients with T2DM and in 159 patients with only CAD. Cut off value of the apoB/apoA-1 ratio was determined from 207 healthy subjects. Severity of CAD was quantified according to the prevalence of multivessel disease and the degree of coronary stenose. Association between the apoB/apoA-1 ratio and the severity of CAD were evaluated using the receiver operating characteristic (ROC) curve and apoB/apoA-1 ratio. ApoB/apoA-1 ratio levels didn’t show significant differences between DM and NDM patients (DM: 0.9±0.5; NDM: 0.8±0.5; P=0.529). In contrast, difference was significant between these groups when patients were categorized...
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Posted by admin on Nov 30, 2016 in |
Bis-[1,5]-benzothiazepines (3a-i) containing two 1,5-benzothiazepine nuclei in a single molecule were synthesized by cyclocondensation reaction of bis-chalcones (1a-i) with two equivalent of 2-aminobenzenethiol (2). All the synthesized compounds were characterized by IR, 1H NMR,13C NMR and mass spectral analysis. Anticancer activity of the synthesized compounds against human breast cancer cell line MCF-7 was determined and the compound (3c) showed significant activity comparable to...
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Posted by admin on Nov 30, 2016 in |
Objectives: The aim of this study was to assess knowledge, attitude and practice of the healthcare professionals about Pharmacovigilance in a tertiary care hospital, Rajahmundry, Andhra Pradesh. Materials and Methods: A cross-sectional questionnaire based study was carried out on healthcare professionals (Faculties, Postgraduates, Interns & Nurses) to assess the knowledge, attitude and practice regarding Pharmacovigilance. Those who gave their consent to participate were included in the study. The obtained data was analyzed using the Statistical Package for Social Sciences (SPSS) statistical software, version 21. Qualitative variables were expressed as percentages and Chi-square test was used to compare the difference in correct responses for each question. For all statistical analysis p<0.05 was considered statistically significant. Results: 290 pretested questionnaires were distributed among the participants, out of whom 272 responded. The study results showed that more than 55% of the study participants had knowledge and attitude regarding Pharmacovigilance but in the matter of practice of Pharmacovigilance less percentage of participants had experience. A major difference was noted between ADR (Adverse drug...
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