Posted by admin on Jul 31, 2016 in |
Liver toxicity faces a major challenge in world health issues. Many drugs are being withdrawn from the market by Food and Drug Administration (FDA) for causing drug induced hepatotoxicity. In the present study, ameliorative activity of methanoic extracts of different parts (Peel, Pulp and seed) of exotic fruits and vegetables on carbon tetrachloride (CCl4)-induced hepatotoxicity were studied in in vitro condition. Chicken liver cell suspension treated with CCl4 was used for lipid peroxidation (LPO), free radical scavenging and sodium dismutase (SOD) assay. Extracts from different parts of exotic fruits and common vegetables showed potent antioxidant effect. In the present study even, methanoic extract of some unused parts (peel & seed) of vegetables and fruits showed hepatoprotective action, but among all these bottle gourd pulp (vegetable) and passion fruit pulp (exotic fruit) showed the noteworthy hepatoprotective action. Thus it is concluded that, the methanoic extracts of exotic fruits and vegetables was observed to have notable protective activity on CCl4 induced...
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Posted by admin on Jul 31, 2016 in |
Aims and Objectives: To evaluate the use and the impact of interventions on the use of antimicrobial agents (AMAs) at Primary Health Centres (PHCs) and Urban Health Centres (UHCs) in Ahmedabad district. Materials and methods: This was an interventional and prospective study carried out at 5 PHCs and 5 UHCs of ahmedabad district. In pre-intervention phase, 30 adult patients from each centre who were prescribed AMAs were included. Educational interventions were done for the prescribers by giving them booklet and by PowerPoint presentation about the use of AMAs for common diseases observed in the pre-intervention phase. In post-intervention phase, similar to pre-intervention phase, 30 adult patients from each centre i.e. 5 PHCs and 5 UHCs who were prescribed AMA were included. The impact of intervention and appropriateness of AMA use was measured using Modified Kunin’s Criteria. Results: Amongst a total of 300 patients, i.e. 150 each from PHCs and UHCs, the most commonly AMAs used were metronidazole and doxycycline respectively in pre-intervention phase. According to modified Kunin’s criteria, appropriate...
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Posted by admin on Jul 31, 2016 in |
The purpose of this study was to evaluate antistress activity of roots of Diospyros malabarica (Desr.) Kostel (DMDK) against anoxia stress tolerance, chemical induced stress, swimming endurance stress and immobilisation stress models in mice and rats. Ethanolic extract of roots of DMDK (EERDMDK) was screened for its antistress activity at 125 mg/kg, 250 mg/kg, 500 mg/kg, p.o. doses and diazepam was selected as reference standard at 2 mg/kg i.p. dose. Stress was induced by anoxia stress tolerance, chemical induced, swimming endurance and immobilisation stress models in mice and rats. The antistress activity was evaluated by measuring anoxia stress tolerance time, number of writhes, immobility time, organs weight of animals and estimating biochemical parameters such as glucose, cholesterol and blood urea nitrogen. Pretreatment with EERDMDK showed significant increases in anoxia stress tolerance time and significant decreases in number of writhes and immobility time in mice and this effect was dose dependent when compared to control. In immobilisation stress model pretreatment with EERDMDK showed significant reduction in level of biochemical parameters...
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Posted by admin on Jul 31, 2016 in |
Cancer is a major health problem; almost thought – out the world. Herbal medicines have a vital role in the prevention and treatment of cancer. The present study, the in vitro anticancer activity of Calophyllum inophyllum ethanolic leaf extract was evaluated in MCF-7 Breast cancer cell lines. Anticancer activity was evaluated with MTT standard colorimetric assay against MCF-7 cells with IC50 value of 120µg/mL. The biologically active metabolites were identified and quantified by a GC-MS method shows presence of 11 different bioactive compounds. The cytotoxic effect was found to be concentration dependent. Increased concentration of the leaf extract showed increased...
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Posted by admin on Jul 31, 2016 in |
Although the antioxidant and thrombolytic potential of the “super fruit” pomegranate has been well established and documented in in vitro models, its efficacy in an animal model has not been recognised. Therefore in the present study, the aril and rind of Punica granatum were scrutinized for their role in clot lysing competence in a thrombus induced rat model. Visual manifestation, coagulation time parameters and the level of the thrombotic factors confirmed the thrombolysis. The extracts were compared with the standard drug streptokinase that was administered in...
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