Posted by admin on Jun 30, 2016 in |
Objective: Conventionally, sustained release pellets have been prepared in the form of reservoir systems by coating non-pareil pellets which is an expensive and tedious process. The aim of present study was to develop sustained release matrix (SRM) pellets of Nateglinide (NT), an oral antidiabetic agent, commonly used in the treatment of Type 2 Diabetes mellitus. Methods: The SRM pellet formulations of NT were prepared with different polymers like HPMC K4, HPMC K15, Kollidon® SR (K-SR), Hydrogenated castor oil (K-HCO) by extrusion spheronization process. The SRM pellet formulations were characterized for micromeritics properties, aspect ratio, sphericity, friability, Kawakita analysis, Fourier transform infrared spectroscopy (FTIR), drug content and In vitro drug release studies. Results: The optimized formulation of SRM pellets (Batch F7) prepared by using K-SR (35%w/w) and K-HCO (15 %w/w) has shown desired sphericity and excellent micromeritics properties. The friability and drug content value were found in the range of 0.22- 0.81% and 96.8-99.7% respectively for all formulations. FTIR spectroscopy studies have not revealed any chemical interaction between the NT...
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Posted by admin on Jun 30, 2016 in |
Acne vulgaris, the inflammatory disease of sebaceous follicles of skin with Propioni bacterium acnes (an anaerobic pathogen) play deliberate role in its pathogenesis by inducing certain inflammatory mediators. The aim of present study was to evaluate the antibacterial activity of crude ethanolic extract of Mentha piperata and essential oil of the peel of Citrus limetta (extracted by hydrodistillation process) and control (Tetracycline) against Propioni bacterium acnes (MTCC 1951). Under the technique of Broth Micro dilution method, recommended by CLSI (NCCLS), for MICs as well as IC50 values analyzed. The oil of Citrus limetta (MIC: 2.99, IC50: 1.889) found to be highly active. Mentha piperata shows comparatively low activity (MIC: RANGE, IC50:0.345). The activities were compared with reading of standard...
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Posted by admin on Jun 30, 2016 in |
A simultaneous stability-indicating reversed-phase high performance liquid chromatography (HPLC) method for analysis of abacavir (ABC), dolutegravir (DTG) and lamivudine (3TC) as the bulk drug and in the formulation was developed. Compounds were separated on Kinetex 5 µ C18 100 A (250 mm x 4.6 mm). A gradient program of mobile phase at different proportions of acetonitrile (ACN) and water was used. The retention times of ABC, DTG and 3TC were 5.2, 8.4 and 3.1 minutes (mins) respectively. The drugs were subjected to the stress conditions of acid, base, oxidative, hydrolytic, humidity, thermal and photolytic degradation. The degradation products were well resolved from main peak and its impurities, proving the stability-indicating ability of the method. The method was linear in the concentration range of 20–100 μg/mL, 2-16μg/mL and 10-80 μg/mL for ABC, DTG and 3TC respectively. The method was accurate and precise with a limit of detection and limit of quantitation of 2.05 and 6.73 µg/ mL, 0.28 and 0.94 µg/ mL and 2.32 and 7.72 µg/ mL for ABC,...
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Posted by admin on Jun 30, 2016 in |
A simple, accurate, economic and rapid method for the simultaneous estimation of Alfuzosin and Dutasteride by RP-HPLC, as a result simple, economic, precise and accurate methods was developed and validated by Reverse Phase High performance Liquid Chromatography in tablet dosage form. The mobile phase consisted of Acetonitrile and Buffer solution in the ratio of (75:25) was eluted through universil C18 column (150 mm x 4.6 mm, i.d., 5µm particle) at a flow rate of 1.0 ml/min. The column temperature was 25ºC. The eluent was monitored at 225 nm for detection of Alfuzosin and Dutasteride by the UV detector. The detection time was 8 min. The validation of HPLC method was carried out in accordance with the ICH...
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Posted by admin on Jun 30, 2016 in |
Background: Human muscle mass undergoes constant changes as one getting older. This change can be accelerated by inadequate nutrition. The aim of the study is to investigate the association between food insecurity and its association with muscle mass strength. Methods: The cross-sectional and case-control study was conducted among 310 men and 334 women (60 and over) from August 2014−July 2015 in Tehran. A pilot study was conducted before initiation of the study to validate equipment. Food insecurity data were collected using Household Food Insecurity Access Scale. Muscles mass strengths were analyzed by Bioelectronics impedance analysis, Squeeze bulb dynamometer. Conclusion: Elderly people living in food insecurity status had scored lower mean standard deviation of muscle mass strength. Food security is a key factor to sustainin c7489-02), and the 6-step walk test. Association between food insecurity and other variables were analyzed by SPSS software. Results: Findings showed that food insecurity prevalence was (29%). It also showed (10%) elderly women and (21%) men had low muscle mass, (24.3%) elderly women and (19.4%)...
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