Posted by admin on May 31, 2016 in |
Caralluma lasiantha is a succulent plant belongs to Ascalpedaceae family. The objective of this study was to evaluate and to compare the anti-hyperglycemic effect of Caralluma lasiantha with Chromium Picolinate on hyperglycemia induced by Cafeteria-Diet in Wistar albino rats. Hyperglycemia was induced in experimental rats by feeding Cafeteria-Diet for a study period of 90 days. Caralluma lasiantha (10, 20, and 40 mg/kg b.w.) & Chromium Picolinate (10 mg/kg b.w.) were administered orally once every day throughout the study and serum glucose levels were determined in different experimental days. Treatment with Caralluma lasiantha significantly reduced the serum glucose level in dose dependant manner. Data reveal an appreciated beneficial effect of Caralluma lasiantha on hyperglycemic rats. Caralluma lasiantha possesses anti-hyperglycemic effect, which promisingly support the use of Caralluma lasiantha as a food supplement or an adjunct treatment for...
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Posted by admin on May 31, 2016 in |
The effects of zingerone, on antidiabetic and hypolipidemic potential in streptozotocin-induced diabetic rats were investigated in the present study. Diabetes mellitus was induced by a single intraperitoneal administration of streptozotocin (40 mg/kg bwt). Five days after STZ administration, diabetic rats received zingerone (10 mg/kg bwt) orally for 30 days. Metformin (Met) was used as reference drug. Zingerone treatment significantly reduced blood glucose level, Lipid profiles of serum, liver and kidney showed higher reduction in the levels of phospholipids, triglycerides and free fatty acids of zingerone treated diabetic rats than STZ-induced diabetic rats and Met-treated diabetic rats. In addition, zingerone treatment of STZ-rats was found to be effective in preserving the normal histological appearance of pancreatic islets, liver, and kidney, whereas the untreated diabetic rats exhibited pathological features. Thus, zingerone may have the potential in managing the effects of diabetic complications in human...
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Posted by admin on May 31, 2016 in |
Objective: The present work is aimed to screen phytochemicals, in vitro antimicrobial and antioxidant activity of the non polar and polar extracts of Acacia sinuata. Methods: Leaves of Acacia sinuata– were collected, dried and powdered. The powdered material is subjected to soxhlet extraction using various polar to non polar solvents and allowed for evaporation. The crude extracts thus obtained were used for further screening of phytochemicals, in vitro antimicrobial activity and antioxidant activities. Results: Phytochemical evaluation of Acacia sinuata proved that most of the secondary metabolites are extracted in polar solvents than non polar solvent like hexane. All the extracts of the Acacia sinuata possess significant amount of phenols and flavonoids and they also showed antimicrobial and antioxidant activity. Out of all the extracts of Acacia sinuata, methanol extracts showed better antibacterial, antifungal activity and antioxidant activity. Conclusion: The present work concluded that the methanol extract of Acacia sinuata was useful to develop new plant based dugs against various pathogenic bacteria as well as fungal...
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Posted by admin on May 31, 2016 in |
High performance thin layer chromatography (HPTLC) offers many advantages over HPLC. It reduces the cost of analysis as compared to HPLC. The mobile phase consumption per sample is extremely low in HPTLC, hence reducing the acquisition and disposal cost. Considering the cost and suitability of analysis for estimation of cinnarizine in bulk and its marketed formulation, HPTLC method was developed and validated. The Camag HPTLC system, employed with software win CATS (ver.1.4.1.8) was used for proposed analytical work. Planar chromatographic development was carried out with the help of Silica Gel 60 F254precoated TLC plates. Sample application was facilitated by Linomat 5 applicator. After sample application plates were subjected for ascending development in twin trough chamber of 10×10 cm dimension, using 10 ml of solvent system. The optimized mobile phase was composed of toluene: ethanol (7.5:2.5 v/v). In post development, the plates were air dried and then scanned densitometrically using a UV detector at 254 nm in absorbance mode. In HPTLC densitogram well defined peak was obtained for cinnarizine with...
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Posted by admin on May 31, 2016 in |
The present study explores the nutritional properties of R. mucronata leaves, an edible red mangrove which has been proven as an antidiabetic and as an alternative source of tea leaves and animal feed. Proximate composition, amino acid profiles and physico-chemical properties were analyzed to evaluate the nutritional property. Nutritional evaluation of R.mucronata illustrates it as a rich source of essential aminoacids and unsaturated fatty acid (alpha linoleic and linoleic acid). Total dietary fiber content, protein, ash, carbohydrate and lipid content was found to be 11.9 ± 0.2, 2.445 ± 0.179, 13.5 ± 0.0021, 79.277± 0.079 and 0.749 ± 0.049 % DW respectively. Mineral and vitamin analysis per 100 g (DW) showed the presence of sodium (80.804 ± 4.0 g), calcium (22.32± 1.1g), potassium (7.96 ± 3.9 g), iron (53.6 ± 0.5mg), magnesium (38.15 ± 0.38 mg) and Vitamin A (2.2 ± 0.02 mg), Vitamin C (3.23 ± 2.3g), Vitamin E (1.180± 1.8 g), vitamin B1 and B2 (18.04 ±0.1 and 0.89 ± 0.08 mg). Swelling, water-holding and oil-holding capacity...
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