Posted by admin on Mar 31, 2020 in |
Increasing demand of herbal medicines in the treatment of diseases has once again gained the immense importance due to its viable efficacy and compliance to the patients. Cucumis sativus L. is commonly known as cucumber and Khayarain in Unani medicine. It is found wildly in the Himalayan regions and also cultivated throughout India. Maghze tukhme khayarain (seeds of Cucumis) is in use in traditional Unani medicine for various ailments such as Waram al-mathana (Cystitis), ziabetes (Diabetes), waram al-shoab (bronchitis), zaheer (diarrhoea), and renal diseases as it possesses musakkin-i-safra (yellow bile), muskkain-i-hiddat–i-dam(blood), Muhallil (anti-inflammatory) and Mudi-i-bawl (diuretic) properties. Not only seeds but other parts of the Cucumis such as root, leaves, flower, and fruits are also useful in various diseases. Further, the various part of the plant contains phytochemical constituents such as potassium, cucurbitacin A, B, C and D, flavanoid-fisetin, ascorbic acid, lactic acid, lariciresinol, pinoresinol and secoisolariciresinol, saponin and hypo-xanthine. Furthermore, it is pharmacologically proven for analgesic, anti-carcinogenic, anti-inflammatory, anti-microbial, anti-oxidant, diuretic, hypoglycemic, hepatoprotective and wound healing activities. As...
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Posted by admin on Mar 31, 2020 in |
For treatment or management of diseases, oral delivery is giving much more attention from the ancient decade. A new concept in oral delivery is mouth dissolving tablets (MDTs) are widely accepted nowadays. Mouth dissolving tablets are solid dosage forms which, when placed in the mouth, disintegrate, dissolve and release active agent within a few minutes without the need for water. It has more significance to geriatric, Pediatric, bedridden patients because they have a problem in swallowing and the patient with dysphasia. It is more useful for the traveler and busy patients who don’t have easy access to water. Mouth dissolving tablets are prepared by various technologies with the aid of superdisintegrants. Mouth dissolving tablets are more reliable than conventional dosage forms like tablets, capsules because of better patient compliance. The advancement in this field allows the development of an economic and better way of disease management with avoidance of several problems related to the other delivery...
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Posted by admin on Feb 29, 2020 in |
Lung cancer is a malevolent lung growth characterized by unrestrained cell expansion in tissues of the lung. EGFR is occupied dissimilar fundamental presentation of cancer cells that includes expansion of cells, enlargement, propagation, apoptosis regulation etc. make it a prime objective for lung cancer. EGFR is a tyrosine kinase inhibitor that is proposed in epithelial cells. EGFR inhibitors are drugs that connect to firm parts of EGFR and stop the expansion of cells. Till date, EGFR inhibitors are classified into two categories first one is tyrosine kinase inhibitor and the second one is monoclonal antibodies. Tyrosine kinase inhibitor binds to the area of tyrosine kinase in the epidermal growth factor receptor and hinders the activity of EGFR. Monoclonal antibodies bind to the extracellular components of EGFR prevent it to bind with its own receptor so that stop cell division. This review encompasses complete updates on a generation of epidermal growth factor receptor tyrosine kinase inhibitor used in the treatment of non-small cell lung...
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Posted by admin on Feb 29, 2020 in |
Despite years of intensive research, impairment in metabolic pathways due to type 2 diabetes mellitus continues to be a daunting global challenge. It is equally challenging problem in this region as well. In recent years there is growing clinical and experimental evidence that oxidative stress plays an important role in induction and promotion of diabetes and its associated complications. Lipid peroxides are known to be essential consequence of biological processes of excessive oxidative cellular damage can be a cause of consequences of numerous diseases, micro and macro complications of type 2 diabetes mellitus. There have been reports of elevated lipid peroxide levels in type 2 diabetes. To defend themselves against these free radical attacks, cell has developed different antioxidant systems. There are low molecular weight antioxidant molecules like uric acid, ascorbic acid, etc. and antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidases. Under physiological conditions, these defense mechanisms maintain a low steady-state concentration of free radicals in the cell and their activities are very precisely regulated. The levels of...
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Posted by admin on Feb 29, 2020 in |
Bacteriophages are particular infective agents of diverse bacteria. They are separated into different groups according to their life cycle. The lytic phages kill their host cells; this property can be applied for the selective elimination of pathogenic bacteria. The first bacteriophage treatment was described one hundred years ago, and phage therapy had been extensively used until the Second World War. Upon the appearance of antibiotics, the medical application of phages retrograded in most parts of the world. In the last decades, owing to the costs of development of new antibiotics and the rapid emergence of multidrug-resistant bacteria, this old approach was revitalized and phage-based treatment was legalized from the middle of the last decade. Here, they summarize the current knowledge on phage therapy, its advantages and potential drawbacks. The current status of phage therapy against food-borne, animal and human pathogens is also presented. Among these, special focus is set on phages E. Amy of Staphylococcus aureus, Salmonella typhimurium and Listeria monocytogenes. Phage cocktails against Listeria monocytogenes and E. amylovora...
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