Posted by admin on Dec 25, 2014 in |
Selaginella bryopteris (L.) Bak. usually known as “Sanjeevani’, is a lithophyte with remarkable resurrection capabilities and medicinal properties. It is traditionally used for curing wounds and irregular menstruation, uterine disorders and other internal injuries. It contains a variety of secondary metabolites such as alkaloids, phenol and terpenoids etc due to which it can act as antioxidants, anti-inflammatory, anti-cancer, anti-allergic, antimicrobial, antifungal, antibacterial, antiviral etc. It is also used as a strength tonic to improve fitness and to extend lifespan by the local tribal communities of India. The herbs are extensively exploited and sold throughout the country in different markets. There is an urgent need to aware the scientist, researchers, forest officials and local peoples about its medicinal properties, traditional knowledge, economic potential, endemic nature, horticultural and aesthetic value. Its distribution, medicinal and economic potential, taxonomy, ecology, causes of depletion and conservation strategies discussed in...
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Posted by admin on Dec 25, 2014 in |
Chitosan a natural polymer available and easy to produce in countless parts of the world; is a material that can significantly improve the standard of living in developing countries where the industry is often surpassing the need to protect the environment and/or where the environment protection is strongly dependent on limited financial resources available to those in charge of environmental protection. Its physicochemical properties such as its poor solubility in water or in organic solvents limit its utilization for a specific application. A smart way is to impart new properties to chitosan is its chemical modification of chain, generally by grafting of functional groups without disturbing the initial skeleton in order to keep the original properties intact. In this way the modified chitosan offers huge relevance in terms of its modified derivatives. The present review is dedicated to the advancements in the chitosan based derivatives and their special attention in food industry as the packaging material is also...
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Posted by admin on Dec 25, 2014 in |
Up till now, the most thriving and extensively used antineoplastic agent with well-established effectiveness is cisplatin. Being a non-specific drug, it reacts not only with genomic DNA but also binds and damages the plasma protein and cytoplasmic protein that confers to cisplatin resistance and severs side effects. DNA damage prompted by cisplatin leads to the activation of many signaling cascades that clue to cell death. This review work comprises interactive pathways of cisplatin with mitochondrial proteins such as p53, p38, p73 and c-Abl which contribute their role in cell death. In addition, disturbance in drug efflux and influx and competent role of repair protein also share in cisplatin resistance. Inhibition of Akt, MKPI, cabl stimulation, amplified activity of p53, p73, and MAPK, increased expression of pro apoptotics (Bax, Bck, Bcd) and decreased expression of anti apoptotic pointers to cisplatin sensitivity. Innovative creation or amendment in a platinum based drug which can magnify the numerous advantageous pathways and precisely constrains the various undesired pathways would greatly contribute to conquest against...
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Posted by admin on Dec 25, 2014 in |
Aim: To investigate the antiparkinsonism activity of hydro alcoholic root extract of P. zeylanica L (PZE) alone and its combination with aqueous extract of C. sinensis leaves (AECS) in reserpine induced model. Materials and methods: Parkinsonism (PD) was induced by sub cutaneous administration of reserpine (1 mg/kg) for 5 days. The extracts/drugs being tested were administered orally (p.o) 60 min prior to the administration of the reserpine for five days. Behavior parameters were analyzed using catalepsy, open field and stepping test. Result: Repeated administration of reserpine (1 mg/kg; s.c) for a period of 5 days significantly increased catalepsy and decreased the locomotor activity as compared to normal animal. All the groups ie L-dopa + carbidopa (syndopa), PZE alone and its combination with C. sinensis showed significant (P<0.001) reduction in catalepsy, akinesia and increase in locomotor performance.Conclusion: It is concluded that P. zeylanica alone and its combination with C. sinensis have a protective effect against PD, while bi-herbal extracts showed more significant protective effect. Hence may offer a safer therapeutic...
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Posted by admin on Dec 25, 2014 in |
Column chromatography of ethyl acetate of Bauhinia retusa afforded a novel flavonoid identified as [ rhamnetin-3-O-α- L-rhamnopyranosyl-3’-O-(prop-1-enyl)], in addition to kaempferol, isorhamnetin-3-α-rhamnoside, qurcitrin, quercetin 3-O-β-D-glucopyranosyl-β-D-glucopyranoside, and quercetin 3,7-di-o- β-D-glucoside have been isolated for the first time. Their structures were established from extensive spectroscopic techniques (UV, MS, 1H and 13C-NMR), chemical studies in addition to comparison with literature data and /or authentic samples. More over,qurcitrin, quercetin 3-O-β-D-glucopyranosyl-β-D-glucopyranoside and ethyl acetate fraction exerted pronounced antioxidant activities (SC50 µg/ml ,13.5 , 14.7 and 18.7 ) respectively, compared with vitamin C (SC50,,13.9 µg/ml ) by DPPH radical scavenging...
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