Posted by admin on Dec 31, 2022 in |
Breast cancer (BC) is one of the most prevalent cancers in women; there were 2.3 million women diagnosed with breast cancer globally. Unfortunately, most anticancer drugs have reported high Potential toxicity, mutagenic and carcinogenic side effects. Existing treatments can neither stop its propagation and/or recurrence nor are specific for cancer cells. Hence the side effects on healthy tissues and cells are common. There is a need to improvise the patient’s quality of life and the efficiency of the treatments, which can be potentiated with reduced toxicity. Nanotechnology has vast applications in diagnosing, treating and preventing breast cancer. Nanotechnology offers new alternatives for the design that can be used in cancer treatment and has now become a very promising tool for its use against breast cancer. In this review, we provide a broad overview on the use of nanotechnology in the fight against breast cancer. We have analyzed the latest research (2019-2021) in nanotechnology as a potential step for breast cancer treatment. We also give a brief summary of the...
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Posted by admin on Dec 31, 2022 in |
Current work makes known that Liquid Chromatography-Mass Spectrometry (LC-MS) method development and validation for the impurity G (N, N -dimethylpyridin-4-amine) and impurity S (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl) methoxy] ethyl N-[1,1-dimetylethoxy) carbonyl]-L-valinate) in Valaciclovir Hydrochloride Hydrate active pharmaceutical ingredient (API). The developed LC-MS analytical method is complimentary to the thin layer chromatography (TLC) method available for impurity G and impurity S quantitation in the Valaciclovir Hydrochloride Hydrate API monograph. Impurity G and Impurity S were determined by the LC-MS method in Q1 Multiple ion mode using Ascentis Express C18 (15cm X 4.6 mm) 2.7µm analytical HPLC column. A gradient system was employed for the elution of analytes using acetonitrile (Eluent B) and 0.01M Ammonium Formate, LC-MS compatible volatile buffer, pH 3.0 (Eluent A) in distinct compositions. The gradient system (T/%B) was applied as 0.01/5, 4.00/5, 7.50/80, 10.00/80, 12.50/5, and 20.00/5. A method developed was validated considering the International Conference on Harmonization pharmaceutical guidelines. The quantitation limit found for Impurity G and Impurity S were 207.20ppm and 216.00...
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Posted by admin on Dec 31, 2022 in |
Recently, scientific investigations of medicinal plants using indigenous medical systems have attracted a lot of attention in international investigation. Nature has imparted our planet with an enormous wealth of medicinal plants known for bestowing and are highly esteemed worldwide as a rich source of therapeutic agents for the prevention and cure of diseases and ailments. Since their chemical characterization in the 19th century, herbal bioactive compounds have fueled drug development. Herbal drugs can be potential drugs to replace them. Every year, many plants from the traditional medicinal system may be screened for their potential analgesic activity. Still, only a few of them only included in the health care system after clinical research. So this is time to give more emphasis on research work based on natural sources, investigate the active phytochemical constituents, and use them on a specific...
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Posted by admin on Dec 31, 2022 in |
Drug addiction has become a worldwide problem and the leading cause of death. In recent years, India is seeing a rising trend in drug addiction. The most common drug use in India is alcohol, followed by cannabis and opiates. Drug use, whether licit or illicit, causes serious health problems in individuals. The national survey on drug use in India indicated that the prevalence of drug abuse among males in the general population is significant. Economic burdens disturbed family environments, violence, and psychological problems are other consequences of drug abuse in the family. Adolescent drug abuse is another major area of concern because more than half of the person’s with substance use disorder are introduced to drugs before the age of 15-year Drug treatment is intended to help addicted individuals stop compulsive drug seeking and use. Treatment can occur in a variety of settings, take many different forms, and last for different lengths of time. Because drug addiction is typically a chronic disorder characterized by occasional relapses, short-term, one-time treatment...
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Posted by admin on Dec 31, 2022 in |
Glibenclamide belongs to a group of medicines called sulfonylureas. Glibenclamide is used to manage diabetes. Glibenclamide, also known as glyburide, is an antidiabetic medication used to treat type 2 diabetes. The purpose of the present study was to formulate an Oral dispersible tablet of Glibenclamide using the Solid dispersion technique through using polyethylene glycol ratio as a water-soluble carrier. The solid dispersion of Glibenclamide was prepared by using fusion methods. The characterization of Glibeclamide solid dispersion powder was done by using several parameters like bulk density, tapped density, Carr’s Index, Hausners’s ratio, drug content, solubility and in-vitro dissolution study. While the oral dispersible tablet was prepared by using direct compression method. The prepared tablets were evaluated for disintegration time, moisture content, friability, and wetting time. From this study, it can be concluded that fast disintegrating tablets could be a potential drug delivery technology for managing diabetic...
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