Posted by admin on Jan 1, 2014 in |
Croton membranaceus (Mull. Arg.) Euphorbiaceae is a shrub that grows wild in West Africa. It is used by Ghanaian Traditional Medical Practitioners in the treatment of benign prostatic hyperplasia (BPH). Research findings have provided some scientific bases for the use of this plant in the treatment of BPH. Therefore, the aim of the present study was to investigate the antihyperglycaemic and antioxidant activities of C. membranaceus. There isalso evidence suggesting an association between BPH and diabetes through a common pathogenic mechanism. Research findings also suggest that oxidative stress may be one of the major factors responsible for the development of BPH and diabetes. The antihyperglycaemic activity of three different doses (100, 300, 600 mg/kg body weight) of the ethanol (70 %) extract of C. membranaceus root was studied in streptozotocin-induced diabetic rats. The antioxidant activity of the ethanol extract of C. membranaceus root was also investigated using the spectrophotometric 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging method. C. membranaceus root extract showed a dose-dependent reduction of glucose levels over both short term and...
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Posted by admin on Jan 1, 2014 in |
One of the problematic aspects of palliative-hospice care is pharmaceutical providing of the patients at specialized institutions, hospices. The relevance of the work is due to the lack of research about the medicineconsumption by patients at the hospice in Ukraine. Therefore the aim of the research was to study the range, cost, prescription frequency and the cost of patient pharmacotherapy at the hospice.The methods of content and frequency analysis and also,the integrated ABC/FMR/VED-analysis were used for the study.At the first research stagewere analyzed the clinical and basic statistical characteristics of hospice patients. At the second stage, the integrated ABC/FMR/VED analysis of prescribed drugs has been conducted. Then the definition of frequently prescribed medications and main therapeutic groups, using frequency analysis,hasbeen performed. The final step is the calculation of patients pharmacotherapy cost and the individual therapeutic medicationgroups.The analysis of clinical and statistical characteristics of hospice patients has showed that 75.6% of patients at the hospice were women and 48.9% of all diseases present were cardiovascular diseases. 139 medicinal products have...
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Posted by admin on Jan 1, 2014 in |
A spectrophotometric method for determination of cephalexin is proposed. This method is based on the formation of a colored compound in the reaction of cephalexin with sodium 1,2-naphthoquinone-4-sulfonate (NQS). The effects of various experimental parameters in this reaction were investigated and optimized using central composite design (CCD). Twelve experiments with two factors and five levels for each factor were designed. These factors include concentration of NQS and pH. A full-quadratic polynomial equation between the absorbance as the response and the studied parameters was established. After removing the non-significant terms from the model, response surface method was used to obtain the optimum conditions. The optimum values of factors were 20.0×10-4 M for concentration of NQS and 9.6 for pH. The maximum absorption wavelength and the value of absorptivity of the colored product were 475 nm and 1.79×103 L mol−1 cm−1, respectively. The absorbance of the reaction product obeys Beer’s law in the range 1.5-34.0 mgL-1. The detection limit of the method was 0.43 mgL-1. This method is rapid and simple,...
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Posted by admin on Jan 1, 2013 in |
Dalbergia spinosa Roxb. (Leguminosae) is a mangrove plant native to Asia and enjoys number of traditional uses. This paper describes the investigation of antibacterial and cytotoxic activity of the ethanol extract of D. spinosa leaves. Antibacterial activity of the ethanol extract of D. spinosa leaves was tested by disc diffusion assay and broth macrodilution assay. The extract was also tested for brine shrimp lethality. The extract showed antibacterial activity against a wide range of Gram-positive and Gram-negative bacteria in both assays. The minimum inhibitory concentrations (MIC) against these bacteria were in the range of 250-500 μg/mL. The LC50 against brine shrimp nauplii was 84.14 μg/mL. The above data demonstrates that the plant has some important biological activities with sufficient potency and further studies can be performed to identify the active...
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Posted by admin on Jan 1, 2013 in |
Felodipine is a long-acting 1, 4-dihydropyridine calcium channel blocker, used to control hypertension by selective action on peripheral resistance. The conventional felodipine tablet gives a rather high peak and comparatively low trough levels, due to rapid absorption and distribution. More sustained plasma concentrations might thus produce a more even effect on blood pressure. The main aim of the study was to improve dissolution rate of the dosage form in a controlled manner over extended period of 24 hrs. Matrix tablets were prepared by direct compression method,using hydrophobic polymers like Glyceryl monostearate and Carnauba wax. The prepared formulations were evaluated for hardness, thickness, weight variation, friability and in-vitro dissolution studies. Among all the formulations F8 was selected as optimized formulation based on the evaluation parameters and in-vitro release profile of 100% drug release for 24 hrs. The FTIR and DSC results of optimized formulation showed no drug-excipient interaction. For optimized formulation(F8), the drug release mechanism was explored and explained by zero-order (r2=0.984), first-order (r2=0.947), Higuchi (r2=0.967) and Korsmayer-peppas (r2=0.982 &...
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