Posted by admin on Jan 1, 2012 in |
The objective of the present study to develop controlled release tablets of Metoprolol succinate using Natural polymer, guar gum and synthetic polymer, carbopol as a rate controlling polymers.. It was also desired to study the effect of polymer concentration. Metoprolol succinate, β1- selective adrenergic receptor- blocking agent used in the management of hypertension, angina pectoris, cardiac arrthymias, myocardial infarction, heart failure, hyperthyroidism and in the prophylactic treatment of migraine. The half-life of drug is relatively short approximately 4-6 hrs and in normal course of therapy drug administration is required every 4-6 hrs, thus warrants the use of controlled release formulation for prolong action and to improve patient compliance. In the present investigation Natural polymer, guar gum and synthetic polymer, carbopol have been selected as matrix forming materials for the drug. The formulations are made by employing the conventional wet granulation method, to achieve prolonged release of...
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Posted by admin on Jan 1, 2012 in |
The objective of the present study was to prepare and evaluate gastroretentive floating drug delivery system containing famotidine as a model drug. Famotidine tablets were prepared by wet granulation method using two different grades of hydroxypropylmethyl cellulose- HPMC K4M and HPMC K100M by effervescent technique. Sodium bicarbonate (SB) and citric acid (CA) were incorporated as gas-generating agents. Floating tablets were evaluated for uniformity of weight, thickness, hardness, friability, drug content, in vitro buoyancy and dissolution studies. The effect of effervescent agent on drug release profile and floating properties was also investigated. Prepared tablets exhibited controlled and prolonged drug release profiles while floating over the dissolution medium. Non–Fickian diffusion was confirmed as the drug release mechanism from these tablets, indicating that water diffusion and polymer rearrangement played an essential role in drug release. All the prepared tablets showed good in vitro...
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Posted by admin on Jan 1, 2012 in |
Excipients form a bulk of the finished dosage forms. They affect various properties in the finished products like patient acceptability, dissolution, bioavailability, rate of release of active ingredients etc. Now a day’s many new means of drug delivery systems are coming up which require new excipients to improve the characteristics of the dosage form. Further new excipients are being discovered which are replacing the older ones by having better desirable characteristics. The novel excipients are developed in such a way that they are more compatible with the active ingredients but there are several hurdles in their development. The establishment of safety of novel excipients is a major hindrance in their development. The evaluation of novel excipients requires huge investments of time and money. As a result, pharmaceutical manufacturers are not interested in evaluating novel excipients in terms of safety and efficacy because any discrepancies in their use may cause delays in the approval of the formulations causing a major loss to the manufacturers. Also there are no well defined...
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Posted by admin on Jan 1, 2011 in |
Non-steroidal anti-inflammatory drugs (NSAIDs) have been used to treat various ailments for over 100 years. As a class, these drugs possess anti-inflammatory, anti-allergy, analgesic and antipyretic activity. A series of benzothiazolyl-amides has been synthesized and tested for anti-inflammatory activity. Basic NSAIDs are gaining interest because of their improved biological properties with the aim of improving the therapeutic index through prevention of gastrointestinal complications. The title compounds were identified by performing Thin Layer Chromatography and recording their physical constants. They were further characterized by spectral analysis (IR, 1HNMR, Mass spectroscopy). The effect of the synthesized compounds on inflammation, using the carageenan induced mouse paw edema model was studied. In general, the studied compounds were found to be potent anti-inflammatory agents. Anti-inflammatory activity was influenced by some structural characteristics of the synthesized compounds. Some physicochemical parameters and ADME Properties were computed by using software...
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Posted by admin on Jan 1, 2011 in |
Antioxidant activities of different vegetables Bitter gourd, Tomato and Spinach (Momordica charantia, Lycopersicon esculentum, Spinacia oleracea) were determined. In addition, rapid visual estimation of tannin content, total phenolic, tested for their free radical scavenging activity (FRSA) in the DPPH (1, 1-dephenyl- 2-picrylhydrazil radical) of those samples were assessed. A new technique was used to quickly distinguish between intermediate, moderately high and high tannin content by the development of shades of purple, light blue and deep blue colors (Bitter gourd, Tomato and Spinach) respectively. The total phenolics in methanol solution for all the samples were analyzed with slightly higher value for spinach paste. The % of condensed tannin of all the three vegetables were low as determined by the Vanillin- HCl method respectively. The antioxidant activity with DPPH- method expressed as per percent inhibition of oxidation ranged from a high of 88% in bitter gourd extract to near about 70% in tomato and spinach respectively. The studies can be further extended to exploit their possible application for the preservation of...
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