Posted by admin on Oct 1, 2010 in |
The present paper deals with the microbial studies of the complex Co(II) & Cu(II) with antibiotic drug Tetracycline, a formula Co (C22 H24 N2 O8) MoO4 4H2O and Cu (C22 H24 N2 O8) MoO4 3H2O has been suggested on the basis of elemental analysis and molar conductance for the newly synthesized complex. The microbial studies of synthesized complex were studied on pathogenic bacteria using gram +ve (Bacillus subtilis and Staphylococcus aureus) and gram -ve (Shigella flexneri, Salmonella typhosa, Escherichia coli) and some fungi (Aspergillus flavus, Fusarium oxysporum, Chrysosporium pannicale, Alternaria solani, Candida albicans )....
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Posted by admin on Oct 1, 2010 in |
A simple, precise and reproducible liquid chromatography–tandem mass spectrometry method has been developed and validated according to the United States – Food and Drug Administration (US-FDA) guidelines for the quantitation of Montelukat in human plasma using Neverapine as an internal standard. Montelukast is a fast acting and potent cysteinyl leukotriene receptor antagonist which is being used in the treatment of asthma. Quantitation was performed on a triple quadrupole mass spectrometer employing electrospray ionization technique, operating in multiple reaction monitoring and positive ion mode. The chromatographic run time was 3.2 mins on a Agilent Zorbax SB C8, 150×4.6 mm, 5.0µm Column. The mobile phase was a mixture of Methanol: 0.1 % Formic acid in water (90:10 v/v). Inter-batch and intra-batch coefficient of variation across four validation runs for the quality control samples was less than 6.02%. The accuracy determined at quality control levels was within 90.98 –...
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Posted by admin on Oct 1, 2010 in |
Rhein and several analogues thereof, are particularly important from commercial point of view and are known for their use in the treatment of degenerative diseases of the joints, for example osteoarthritis, osteoporosis and rheumatoid arthritis. Rhein occurs in nature in plant families such as Cassia, Rheum and Rhamnus, but in a very less concentration. Aloin, a natural substance isolated from various species of aloe, consist almost exclusively of barbaloin (10-β-glucopyranosyl-1, 8-dihydroxy-3-hydroxymethyl-anthracen-9-one). Barbaloin, the C-glycoside of aloe-emodin anthrone, localizes in the outer rind of the aloe vera leaf, has been reported to constitute upto 30% of aloe plants dried leaf exudate and proposed as a part of defense mechanism against herbivores. In this paper, an attempt has been made to prepare rhein from barbaloin via formation of aloe-emodin and its chemical modification using benzyl alcohol to prepare its benzyl carboxylate...
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Posted by admin on Oct 1, 2010 in |
The Western Ghats of Kerala is famous for its medicinal plant wealth and the tradition of indigenous system of therapy, specifically the Ayurveda. Dasapushpam constitute a group of ten potential herbs which are culturally and medicinally significant to the people of Kerala in India. They are a group of ten herbs with which the ladies decorate their hairs and dance the Thiruvathira Kali on the day of Thiruvathira in the Malayalam month of Dhanu. These plants are therapeutically very active for various diseases and ailments. Many of them are traditionally used from time immemorial. Some of them are scientifically validated for various bioactivities. Still there are lots of possibilities for potential pharmacological activities from these herbs, yet to be explored. This article would give an insight of these ten sacred plants and their properties to further popularise these...
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Posted by admin on Oct 1, 2010 in |
The objective of the project is to develop a comprehensive database of Nuclear Receptor (NR) Superfamily-Ligand. Nuclear Receptor Superfamily represents one of the most important families of drug targets in pharmaceutical development. Nuclear Receptor) Superfamily-Ligand is a novel public NR-related chemical genomic database that is primarily focused on the correlation of information between NRs and their ligands. It provides correlation data between NRs and their ligands, along with chemical information on ligands, as well as access information to the various web databases regarding NRs. These data are connected with each other in a relational database, allowing users in the field of NR-related drug discovery to easily retrieve such information from either biological or chemical starting points. NR Superfamily-ligand database includes structure similarity search functions for the NRs and for their ligands. Thus database can provide correlation maps linking the searched homologous NRs (or ligands) with their ligands; we can gain more detailed knowledge about their interactions and improve drug design efforts by focusing on inferred candidates for NR-specific drugs....
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